CELL CYCLE AND TRANSCRIPTION

The tumor suppressor p53 is a sequence-specific transcription factor that regulates an extensive network of coding genes, long non-coding RNAs and microRNAs, that establish intricate gene regulatory circuits influencing many cellular responses beyond the prototypical control of cell cycle, apoptosis[r]

cultivated in SBRs run at different cycle times. As pointed out earlier, poorly settling sludge would be washed out, and only bioparticles with good settleability would be retained in SBRs run at short cycle times. According to the well-known Stokes law, a more compact particl[r]

yes , MHCL , HMBS ) [12] (Table 1A).
Next we determined the suitability of the genes for our assay. The marmoset cell line B95.8 was selected as the ref- erence line because it expresses all of the latent genes and most of the lytic EBV genes under normal culture condi- tions [13].[r]

To identify the mechanism behind, within this study we reviewed the effect of diacerein on cell cycle distribution, the expression of cell cycle checkpoint pro-teins, the mitogen-activat[r]

Under normoxia (3ở+ O 3 ;H DSBs induced by coi
treatment were THiợắ3 concentrationidependent (e and f;à HoweverH under hypoxiaH lower TM values were obi served at higher THiợắ3 concentration (h; than lower concentration (g; due to the superimposition of DNA crossilinkingà Quantification of[r]

BAP1 gene expression was silenced in another LAC cell line NCI-H1650, in order to test the inhibitory effect of BAP1 on cell migration and invasion, as well as cell cycle regulation.. Re[r]

sis transition in double mutant males resulted in improper differentiation and higher rate of apoptosis.
In summary, phosphorylation by Cdk complexes are important for regu- latory events leading to mammalian germ cell development. The interplay of various cyclins and their[r]

Signal transducer and activator of transcription proteins (STATs) play important roles in gene regulation, cell proliferation, and cell differentiation. We aimed to establish the relationship between phosphorylated STAT3 (p-Ser-STAT3) expression and the prognosis of upper tract urothelial carcinoma[r]

Gen vaø ung thö (Gene and cancer)

Söï ñieàu hoaø chu kyø teá baøo (The control of the cell cycle)

Caùc ñöôøng daãn truyeàn tín hieäuGen vaø ung thö (Gene and cancer)

Söï ñieàu hoaø chu kyø teá baøo (The control of the cell cycle)

Caùc ñöôøng daãn truyeàn tín hieäu

REGULATION OF GENE EXPRESSION / 385
best-understood mammalian enhancer systems is that of the β -interferon gene. This gene is induced upon viral infection of mammalian cells. One goal of the cell, once virally infected, is to attempt to mount an antivi- ral response—if not to save the i[r]

is a necessary condition for YB-1 to exert transcriptional control over its downstream gene targets, many of which are stem cell genes [22,25]. This concept also correlates with the previous findings that YB-1 activation, known to be mediated by kinases such as Akt, RSK1/2, and GSK3ß[r]

When curcumin was applied topically to the dorsal skin of female ICR mice (a model initially developed at the Institute of Cancer Research, Fox Chase Cancer Center), it prevented the PMA-induced activation of both Nf- κ b and Ap1 ( REF. 25 ). The inhibition of Nf- κ b was accompanied by block[r]

Curcumin inhibits growth of several cancer cell lines, and studies in this laboratory in bladder and pancreatic cancer cells show that curcumin downregulates specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and pro-oncogenic Sp-regulated genes.

“[w]hat we can learn about cells depends on the tools at our disposal, and major advances in cell biology have frequently sprung from the introduction of new techniques”.
Therefore in training a biologist, a balance between theory and practice should be struck. The phil[r]

TBX3 is a T-box transcription factor repressor that is elevated in metastatic breast cancer and is believed to promote malignancy of tumor cells, possibly by promoting cell survival and epithelial-mesenchymal transition.

FOWKE 3.1 Introduction 62 3.2 Plant CDK inhibitors and sequence uniqueness 64 3.3 Expression 66 3.4 Interactions with cell cycle proteins and CDK inhibition 68 3.5 Protein stability and [r]

Cytokinesis
Cytokinesis, or “cell motion,” is the second main stage of the mitotic phase during which cell division is completed via the physical separation of the cytoplasmic components into two daughter cells. Division is not complete until the cell components have been appo[r]

The Arabidopsis AtMYB80 transcription factor regulates genes involved in pollen development and controls the timing of tapetal programmed cell death (PCD). Downregulation of AtMYB80 expression precedes tapetal degradation.

Abbreviations: ECD: extracellular domain; VEGF: vascular endothelial growth factor; PI3K: phosphoinositide 3-kinase Cell Nucleus HER1, 3 or 4 Breast Cancer Cell Trastuzumab Transcription[r]

flexible disorder. For instance, proteins enriched in flexible disorder have high phenotypic capacitance and are multi- functional. Moreover, they exhibit low-expression coher- ence, that is, are connectors in the cellular network, consistent with a regulatory role [18]. Finally, flexible d[r]