CELL CYCLE

ing such transgenic mice with knockout mice or by using proviral tagging toenhance the frequency or severity of specific cancers. Of course, the abilityto generate these mice from genetically pure or inbred backgrounds, and toexamine time points during embryogenesis or life after birth gives us great[r]

of highly conserved proteins (alpha, beta, delta, sigma, tau, zeta etc.) with molecular weight of 25- to 30-kDa. They are expressed in all eukaryotic cells and modulate a wide variety of cellular processes [20]. They play a critical role in the regulation of signal transduction pathways associated w[r]

Nat Struct Mol Biol 15, 881–888.22 Ng HH, Robert F, Young RA & Struhl K (2003) Tar-geted recruitment of Set1 histone methylase by elongat-ing Pol II provides a localized mark and memory ofrecent transcriptional activity. Mol Cell 11, 709–719.23 Zhang K, Lin WC, Latham JA, Riefler GM, S[r]

decoration of proteins with long ubiquitin chains. Although several differ-ent lysines on ubiquitin can serve as acceptor sites for ubiquitin addition,the predominant linkage for protein turnover is through lysine 48 (Chenand Pickart 1990). Once chains of significant length have been produced, theFig[r]

tive cycles, cell migration patterns, somatic/germ cell interaction and theinability to propagate germ cells in culture for extended time. Understand-ing mammalian meiosis has benefited considerably by general principles beingconserved across species. Much of our knowledge is built upon[r]

(unsaturated fatty acid) and cholesterol on cell proliferation in cultured cells were tested. HeLa cells were plated at 0.5 · 104cells per wellin 24-well plates. After 1 day’s incubation, the medium was switched to DMEM containing 5% DLS, in the presence or absence of 100 lMoleate or 5 lM cho[r]

24. Fingerle-Rowson G, Petrenko O: MIF coordinates the cell cycle with DNAdamage checkpoints. Lessons from knockout mouse models. Cell Div2007, 2:22.25. Yeh YH, Huang YF, Lin TY, Shieh SY: The cell cycle checkpoint kinaseCHK2 mediates DNA damage-induced stabilizati[r]

24. Fingerle-Rowson G, Petrenko O: MIF coordinates the cell cycle with DNAdamage checkpoints. Lessons from knockout mouse models. Cell Div2007, 2:22.25. Yeh YH, Huang YF, Lin TY, Shieh SY: The cell cycle checkpoint kinaseCHK2 mediates DNA damage-induced stabilizati[r]

ical behavior of biological systems. Control structures in-spired in well-known biological facts, such as the existence ofintegrators, negative and positive feedbacks, and biologicalredundancies, were included in the model architecture. Af-ter adjusting its parameters heuristically, the model was ab[r]

Results Probl Cell Differ (42)P. Kaldis: Cell Cycle RegulationDOI 10.1007/001/Published online: 23 November 2005© Springer-Verlag Berlin Heidelberg 2005Senescence and Cell Cycle ControlHiroaki KiyokawaDepartment of Molecular Pharmacology and Biological Chemistry,Fe[r]

Tumor Suppressor Gene p16/INK4A/CDKN2A and Its Role in Cell Cycle Exit, Differentiation, and Determination of Cell Fate 7 The INK4 family CKIs (the second group) generally inhibit the assembly of CDKs by binding to CDK4 or CDK6 (Sherr & Roberts, 1995). Like p15/INK4B an[r]

ygene. Of particular note is the factthat the deficient mice showed a rate of weight gainand amount of food intake equivalent to measurementstaken under normal diet conditions. Taken together,these results indicate that RMI1-deficient mice cangrow normally despite developing basal abnormalities,sugges[r]

Polypyrimidine tract-binding protein is essential for earlymouse development and embryonic stem cell proliferationMasaki Shibayama*, Satona Ohno*, Takashi Osaka, Reiko Sakamoto, Akinori Tokunaga,Yuhki Nakatake, Mitsuharu Sato and Nobuaki YoshidaLaboratory of Developmental Genetics, Center for[r]

data available concern only Lf and in vitro studies. Lfoligomerization usually occurs in solutions, dependingon the ionic strength and ⁄ or the presence of calcium[38,39]. Lf and DNA complexes were also observedwith a dependence on Lf concentration, with high con-centrations favoring formation of la[r]

This approach significantly reduces smooth muscle cell proliferation and neointimaformation in both the rat carotid and porcine femoral artery models of restenosis.Similar results were also obtained by adenovirus-mediated overexpression, a naturalinhibitor of cell cycle progressi[r]

cycle progression and its molecular basis were investig ated in the pathogenesis of lung cancer.Methods: Using immunohistochemistry analysis, we analyzed CDK4 protein expression in 89 clinicopathologicallycharacterized lung cancer patients (59 males and 30 females) with ages ranging from 36 t[r]

the organs. By using calcium blockers and different media for cells, the authors have provided evidence to support the hypothesis that the level of calcium is the key factor for directing MSC towards the proliferation or differentiation. In the final part of the chapter authors have presented a gene[r]

induces cell cycle arrest and apoptosis of head and necksquamous cell carcinoma and non-small cell lung cancercells. Clin Cancer Res 2005, 11(19 Pt 1):6924-6932.20. Tsao AS, He D, Saigal B, Liu S, Lee JJ, Bakkannagari S, Ordonez NG,Hong WK, Wistuba I, Johnson FM: Inhibiti[r]

Chapter 080. Cancer Cell Biology and Angiogenesis (Part 2) Cancer Cell Biology The treatment of most human cancers with conventional cytoreductive agents has been unsuccessful due to the Gompertzian-like growth kinetics of solid tumors (i.e., tumor growth is exponential in small tumor[r]

Song, ZH.; Ji, ZN.; Lo, CK.; Dong, TT.; Zhao, KJ.; Li, OT.; Haines, CJ.; Kung, SD. & Tsim, KW. (2004). Chemical and biological assessment of a traditional chinese herbal decoction prepared from Radix Astragali and Radix Angelicae Sinensis: orthogonal array design to optimize the extraction o[r]