doi:10.1111/j.1742-4658.2009.06895.xMixed lineage leukemias (MLLs) are histone H3 at lysine 4 (H3K4)-spe-cific methylases that play a critical role in regulating gene expression inhumans. As chromatin condensation, relaxation and differential geneexpression are keys to correct cell c[r]
also mediates cell cycle regulation through p18, p21 cip and cyclin D1 in breast cancer cells. Our results also showed the up-regulation of ERR β promoter activity in ectopically co-expressed ER α and ERR β breast cancer cell lines. Fluorescence- acti[r]
much greater (> 1000-fold). This suggests that the nuclearconcentration of PMLA is regulated to maintain a relativelyconstant, high level in all strains.Fig. 2. Effects of polymalate injection on growth and duration of the cell cycle. Variable amounts of PMLA (A–D) or poly[r]
of bronchioloalveolar carcinomas. Respiration 2005, 72(1):68-73.14. Retzer-Lidl M, Schmid RM, Schneider G: Inhibition of CDK4 impairsproliferation of pancreatic cancer cells and sensitizes towards TRAIL-induced apoptosis via downregulation of survivin. Int J Cancer 2007,121(1):66-75.15. Rodri[r]
cancer. Genes Chromosomes Cancer 2005, 42(2):193-199.6. Dobashi Y, Goto A, Fukayama M, Abe A, Ooi A: Overexpression of cdk4/cyclin D1, a possible mediator of apoptosis and an indicator ofprognosis in human primary lung carcinoma. Int J Cancer 2004,110(4):532-541.7. Fang W, Li X, Jiang Q, Liu[r]
Our previous study showed that GATA6 plays important roles in cholangiocarcinoma (CCA) cell invasion and metastasis. However, the regulation mechanism of GATA6 in CCA is not clear. In this study, we studied the potential function of miR-124 in CCA and the mechanism of GATA6 regulation.
mitochondria and ribosomes [15,16,54], and several studieshave shown that pro-apoptotic effects of p53 do notnecessarily require transcriptional transactivation activity ofthe protein [55–57].Well documented reports have revealed a role for p53 inthe control of translation of individua[r]
connecting tubule) and CCD is the principal cell. Virtually all regulation of renal K+ excretion and total body K+ balance occurs in the distal nephron. Potassium secretion is regulated by two physiologic stimuli—aldosterone and hyperkalemia. Aldosterone is secrete[r]
as an oncogene, gene amplification induces protein over-expression in cell membranes and regulates signal transduction in cellular processes, such as proliferation, differentiation, and cell survival. Aberrant HER2 expression or function has been associated in carcinogene[r]
Methods: We examined the effects of dasatinib on proliferation, chemo-sensitivity, cell cyclearrest, apoptosis, migration and invasion in human melanoma cell lines. Expression and activationof Src kinase, FAK and EphA2 were also examined in the melanoma cells.Resul[r]
from the EBV-positive BL cell lines Namalwa, Raji, Akata,Jijoye, and P3HR1 were labeled and competitively hybrid-ized against B95.8 labeled RNA in dye-swap experiments(Cy3–Cy5) (Fig. 2).We found that EBV gene transcription in all BL cell linestested was, in general[r]
ultraspiracle p rotein for binding to the EcRE sequenceand transactivation [13]. The helix–turn–zipper motif whichseems to be essential for receptor dimerization [49] is presentin PIEcR (Fig. 3).PiEcR had significant amino acid identities (especiallywith the B1 i soform) o f other insect EcRs and<[r]
biological noise in microarray and proteomic studies. These oscillations intranscript and protein levels and the repeated cycles of synthesis and degra-dation they require, represent a high energy cost to the cell which must,from an evolutionary point of view, be r[r]
evolving field. Here, we review the available publishedstudies that show the involvement of miRNAs indifferent aspects of the cardiovascular system.miRNAs have been reviewed recently in several spe-cific systems, including cardiovascular development,cardiac fibrosis and arrhythmia [13–15]. As is[r]
were confirmed: first, feedback regulation requires that DUSP6 mRNAand protein are unstable; and second, the activation kinetics of MAPK areultrasensitive. Taken together, an integrated systems biological approachreveals that transcriptional negative feedback controls the kinetics and[r]
LOUISRE V I EWhas not yet shown itself but will eventuallymaterialize. Such difficulty could engenderexcess risk-taking both at the top of and withinthe firm.For instance, the performance of CEOs isevaluated in part on the basis of the earnings theygenerate relative to their peers. To the ext[r]
sin-like protein RB6K was observed to be expressedsimilarly to cyclin B with RB6K lagging a littlebehind cyclin B expression. In the RB6K promoter atandem element with similarity to known CDE ⁄ CHRsites was observed, but not assayed functionally [52].Furthermore, numerous CDE and CHR sites we[r]