17Β ESTRADIOL AND PROGESTERONE CONTROL MAMMOGENESIS BY STIMULATION OF MAMMARY EPITHELIAL CELLS PROLI...

Aberrant hyperactivation of epithelial proliferation, AKT signaling, and association with unopposed estrogen (E2) exposure is the most common endometrial cancer dysfunction. In the normal uterus, progesterone (P4) inhibits proliferation by coordinating stromal-epithelial cross-talk, which we previou[r]

The balance between regulatory T cells (Tregs) and effector T help cells (Th cells) is critical for the control of adaptive immune response during nerve transplantation. However, whether the homeostasis of immune regulation between Tregs and Th cells requires toll-like receptor (TLR) signaling is un[r]

N3 ¢ -P5 ¢ phosphoroamidates (NPs). N3 ¢ -P5 ¢ phosphoro- amidates (NPs) are another example of a modified phosphate backbone,in which the 3 ¢ -hydroxyl group of the 2 ¢ -deoxyribose ring is replaced by a 3 ¢ -amino group. NPs exhibit both a high affinity towards a complementary R[r]

Estrogen receptor (ER) β has been suggested to affect ovarian carcinogenesis. We examined the effects of four ERβ agonists on proliferation and gene expression of two ovarian cancer cell lines.

(epigenetic, transcriptional, nuclear shuttling, post- transcriptional, translational, and post-translational) Evolution Connection
Evolution of Gene RegulationProkaryotic cells can only regulate gene expression by controlling the amount of t[r]

In this article, we aimed to characterize the diffuse gastric cancer cells with MRI and transcriptomic data. We hypothesized that gene expression pattern is associated with the phenotype of the cells and that the heterogeneous enhancement pattern and the high tumorigenicity of SNU484 can be modulate[r]

b 1 and TSA (data not shown). Hence, none of the HDACs exhibit c-Jun dependent expression.
Although the induction by PMA alone was partially abrogated upon mutation or deletion of the ) 59 ⁄ ) 53 AP-1 motif of Timp-1 , TSA was still able to superin-[r]

Only rotor flux oriented control is elaborated in what follows. Current-fed induction machine is treated first. This is followed by analysis of the voltage-fed induction machine. One important aspect of the discussion that follows is related to the power sup[r]

median overall survival of ≤ 19 months [4]. Androgens,
in particular dihydrotestosterone, are activating ligands of the androgen receptor (AR) transcription factor. Novel highly potent drugs that block either androgen production or its stimulation of the AR have shown e[r]

This article presented research linking gastric cancer to immune cells, based on RNA-seq data of Stomach adenocarcinoma (STAD) and gene expression profile of GSE84437, 24 kinds of tumor-infiltrating immune cells were quantified by single-sample gene set enrichment analysis.

Taken together, these results indicate that induction of miR-221 ⁄ 222 depends on the activation of ERK1 ⁄ 2. However, transient activation of ERK ⁄ 2 upon EGF stimulation did not induce miR-221 ⁄ 222 expression. This observation prompted us to hypothesize t[r]

doi:10.1111/j.1742-4658.2007.05852.x
Ticks feed exclusively on blood to obtain their nutrients, but the gene products that mediate digestion processes in ticks remain unknown. We report the molecular characterization and possible function of a serine carboxypeptidase (HlSCP1)[r]

E2A directly activates the EBF gene [26] and regulates expression of several genes, i.e. k 5, Rag-1, V j 1 and j o, that are involved in D-JH rearrangement, cell survival, Ig j rearrangement, etc [26,27]. E2A directly controls IgH gene expression, <[r]

wide array of tissues, in addition to the classic endocrine source. Thus, ectopic expression is often a quantitative change rather than an absolute change in tissue expression.
Nevertheless, the term ectopic expression is firmly entrenched and[r]

Modulation of CTGF/CCN2 gene expression
As a basis for defining the signaling pathways regulating CTGF/CCN2 gene expression in our system, we first determined the response of primary cultures of SMCs to various stimuli including S1P, a bioactive lysol[r]

Gene expression is regulated by transcription factors binding to specific target DNA sites. Understanding how and where transcription factors bind at genome scale represents an essential step toward our understanding of gene regulation networks.

Inhibition of post entry HIV-1 replication
Figure 5
Inhibition of post entry HIV-1 replication . (A) SupT1 cells were infected for 1.5 hours in the absence of any treat- ment, with HIV-1 chimera NL4-3 Env - Luc + /VSV-G pseudo- type, washed 3 times, and then tr[r]

The epithelial to mesenchymal transition (EMT) plays a key role in lung cancer progression and drug resistance. The dynamics and stability of gene expression patterns as cancer cells transition from E to M at a systems level and relevance to patient outcomes are unknown.

MTT and FCM analysis demonstrated that WIN62577 inhibited the ASMC proliferation induced by IL-13. FCM analysis of the ASMC cell cycle suggested that most ASMC remained at G 1 phase after WIN62577 treatment. G 1 phase is the key to the entire cell cycle, and the[r]

Italy
1. Introduction
Bone tissue represents a specialized connective tissue, comprising metabolically active cells within a mineralized extracellular matrix, that are vital to the performance of its structural, mechanical and metabolic roles (Milat & Ng, 2009). The fi[r]