EPIGENETIC REGULATION OF GENE EXPRESSION

described for the amino acid-dependent regulation ofseveral genes, including Chop, Atf3, Cat-1 and insulin-like growth factor binding protein 1 (Igfbp1), makingit possible that amino acid availability may affect amechanism regulating transcript stability of a larger setof genes [15,25,[r]

shows that samples from NHPs exposed to VEEV wereclustered together and maintained a significant distancefrom the control group along first principal componentaxis (x-axis: PCA1), which, incidentally, represents thehighest variance between the two groups.Confirmation of gene express[r]

shows that samples from NHPs exposed to VEEV wereclustered together and maintained a significant distancefrom the control group along first principal componentaxis (x-axis: PCA1), which, incidentally, represents thehighest variance between the two groups.Confirmation of gene express[r]

doi:10.1111/j.1742-4658.2009.06895.xMixed lineage leukemias (MLLs) are histone H3 at lysine 4 (H3K4)-spe-cific methylases that play a critical role in regulating gene expression inhumans. As chromatin condensation, relaxation and differential geneexpression are keys to correct cell cycl[r]

2 is important in the basal condition, IRF-1 is theprimary regulator of IFN-c-mediated augmentation ofthe gene expression. It is also shown that PU.1, amember of the E26 transformation-specific (Ets) familyof transcription factors, plays a role in the regulationof gene<[r]

ular weight of 13–14 kDa. It has been identified thatectopically expressed G1P3 localized to mitochondria andantagonized TRAIL-mediated mitochondrial potentialloss, cytochrome c release, and apoptosis, which contrib-uted the specificity of G1P3 for the intrinsic apoptosispathway by the[r]

Histone demethylase JARID1B plays several context dependent roles in epigenetic regulation of cellular differentiation in normal development and is highly expressed in multiple human cancers. The protein is a strong transcriptional repressor capable of downregulating numerous genes.

degree of confluence. We used RPMI-1640 medium (30 ml for attachedcells; 40 ml for leukaemias) with phenol red, glutamine (2 mM) and 5%fetal calf serum. For compatibility with the drug-profiling regimen, weobtained all fetal calf serum from a large batch (BioWhittaker) used byDTP. No antibiotic[r]

expression in B lymphocytes is not required for prionneuroinvasion. Nat Med 4, 1429–1433.17 Klein MA, Frigg R, Flechsig E, Raeber AJ, Kalinke U,Bluethmann H, Bootz F, Suter M, Zinkernagel RM &amp;Aguzzi A (1997) A crucial role for B cells in neuroinva-sive scrapie. Nature 390, 687–690.18[r]

of the gene encoding the mRNA cap binding protein (eIF4E)and their function in growth regulation. Mol. Cell. Biol. 18, 5621–5633.32. Bina, M. &amp; Crowely, E. (2001) Sequence patterns defining the 5¢boundary of human genes. Biopolymers 59, 347–355.33. Emami, K.H., Bur[r]

tone methyltransferase in cancer epigenetics. Mutat Res647, 21–29.64 Sander S, Bullinger L, Klapproth K, Fiedler K, KestlerHA, Barth TF, Moller P, Stilgenbauer S, Pollack JR &amp;Wirth T (2008) MYC stimulates EZH2 expression byrepression of its negative regulator miR-26a. Blood 112[r]

Germany.7 Riley RL, Blomberg BB &amp; Frasca D (2005) B cells,E2A, and aging. Immunol Rev 205, 30–47.8 Ikawa T, Kawamoto H, Wright LYT &amp; Murre C(2004) Long-term cultured E2A-deficient hematopoieticprogenitor cells are pluripotent. Immunity 20, 349–360.9 Lazorchak AS, Wojciechowski J, Dai[r]

Hepatocellular carcinoma (HCC) is the leading cause of cancer mortality. Chemical and virus induction are two major risk factors, however, the potential molecular mechanisms of their differences remain elusive.

Gebze Institute of Technology, Kocaeli,Turkey(Received 13 March 2009, revised 26 May2009, accepted 29 June 2009)doi:10.1111/j.1742-4658.2009.07182.xThe dmdR1 gene of Streptomyces coelicolor encodes an important regulatorof iron metabolism. An antiparallel gene (adm) homol[r]

17 amino acids that were critical for 20-hydroxyecdy-sone binding. Mutational analysis at these 17 aminoacids in transactivation assays resulted in the iden-tification of EcR mutants that were better thanwild-type EcR in terms of ligand sensitivity andtransactivation ability [35].We scr[r]

Nutrition Exercise Physiology and Sarcopenia Laboratory Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USAStephen M. RothDepartment of Kinesiology, School of Public Health, University of Maryland, College Park[r]

of the isoenzymes of acetaldehyde dehydrogenase(Ald6p), is degraded preferentially by autophagy [34].Similarly, under some conditions, autophagy can selec-tively remove certain organelles, such as endoplasmicreticulum, mitochondria or peroxisomes [35–37]. Auto-phagy of mitochond[r]

20. Pfaffl MW, Horgan GW, Dempfle L: Relative expression softwaretool (REST©) for group-wise comparison and statistical anal-ysis of relative expression Results in real-time PCR. NucleicAcids Research 2002, 30:E36.21. Cioffi JA, Van Blerkom J, Antczak M, Shafer A, Wittmer S, Sno[r]

13 Sugden MC, Lall HS, Harris RA &amp; Holness MJ (2000)Selective modification of the pyruvate dehydrogenasekinase isoform profile in skeletal muscle in hyperthyr-oidism: implications for the regulatory impact of glucoseon fatty acid oxidation. J Endocrinol 167, 339–345.14 Peters SJ,[r]

mulating in the nucleus upon activation of RhoGTPase signaling, which alters interactions betweenG-actin and the RPEL domain. Guettler et al. [57]showed that the RPEL domain of MRTF-A bindsactin more strongly than the RPEL domain of myocar-din, and that the RPEL motif itself is[r]