ROLE OF OXIDATIVE STRESS IN BREAST CANCER

Cancer development is mediated by oxidative stress and inflammation, which may correlate with metabolic disorders. The aim of this study was to evaluate antioxidant vitamins status and metabolic parameters in patients with oral cancer according to tumor-node-metastasis (TNM) stages.

Therapy targeted to the human epidermal growth factor receptor type 2 (HER2) is used in combination with cytotoxic therapy in treatment of HER2+ breast cancer. Trastuzumab, a monoclonal antibody that targets HER2, has been shown pre-clinically to induce vascular changes that can increase delivery of[r]

Previously, we have shown that miR-18a and miR-18b gene expression strongly correlates with high proliferation, oestrogen receptor -negativity (ER− ), cytokeratin 5/6 positivity and basal-like features of breast cancer.

Downy mildew, caused by Sclerospora graminicola (Sacc.) Schroet, is a disease of great economic significance in the production of pearl millet (Pennisetum glaucum). Host physiology particularly host metabolites and oxidising enzymes get disturbed due to attack of Sclerospora graminicola. Altered sta[r]

INTRODUCTION OF THESIS

1. Background:
Lung cancer is one of the common cancers. The disease has the highest incidence and mortality among cancers, most commonly seen in the elderly especially over 60 years old. The majority of lung cancer is related to secondhand and passive smoking and has over[r]

The adhesion molecule, FAT4, has a tumor suppressor function with a critical role in the epithelial-tomesenchymal-transition (EMT) and anti-malignant growth in several cancers. No study has investigated yet its role in epithelial ovarian cancer (EOC) progression.

... damaging and telomeretelomerase effects and hence the mechanism of action of TQ in breast cancer cells In addition, it is of interest to investigate the effects of TQ in normal breast epithelial cells. .. Black cumin seeds (left) and chemical structure of thymoquinone (right) 23 Figure 10 Growth[r]

molecular chaperones. Cold Spring Harbor Laboratory Press,Cold Spring Harbor, NY, pp 533–5524. Mestril R, Dillmann WH (1995) Heat shock proteins and protection against myocardial ischemia. J Mol Cell Cardiol 27:45–525. Buchner J (1999) hsp90 and Co.—a holding for folding. TrendsBiochem Sci 24:136–14[r]

... EFFECTS OF SULFIDE- CONTAINING COMPOUNDS ON DEVELOPMENT OF ATHEROSCLEROSIS IN HUMAN UNDOTHELIAL CELLS AND HYPERLIPIDEMIC RABBITS WEN YA-DAN Master of Medicine, Soochow University... Effects of SPRC on ultrastructure of thoracic aorta of NZW rabbits 143 4.4.5 Effects of SPRC on oxidative stress[r]

The prevalence and correlates of job and insurance problems were examined among a cohort of young U.S. breast cancer survivors during the first 18-months following diagnosis.

RIPK1 (receptor-interacting protein kinase-1) plays a role in cancer development, whereas no clear studies focused on the cervical cancer. The objective of this study was to evaluate the relationship between RIPK1 polymorphisms and cervical cancer risk among the Uyghur population.

... Establishing the stress models 2.2 Investigation of the role of the NI in stressor-induced HP-mPFC LTP modulation Role of the NI in stress-induced modulation of mPFC-mediated working memory The current... research implicates the potential role of an emerging structure, the nucleus incertus (NI)[r]

To assess metastatic breast cancer (MBC) patient psychological factors, perceptions, and comprehension of tumor genomic testing. This is the only study, to our knowledge, to longitudinally evaluate multiple psychological metrics in MBC as patients undergo tumor genomic testing.

Self-management is becoming essential for breast cancer survivors, but evidence about the effectiveness of self-management support (SMS) intervention is lacking. To address this issue, we developed a theory-based SMS intervention, the ‘EMPOWER’, aimed at empowering breast cancer survivors. Here we d[r]

Long-term survival in numerous cancers often correlates with specific whole transcriptome profiles or the expression patterns of smaller numbers of transcripts. In some instances, these are better predictors of survival than are standard classification methods such as clinical stage or hormone recep[r]

Breast cancer treatment is tailored to the specific cancer subtype. Often, systemic treatment is given prior to surgery. Chemotherapy induces significant endoplasmic reticulum (ER) stress-mediated cell death and upregulation of 78-kDa glucose-regulated protein (GRP78).

Concern for cardiovascular disease (particularly atrial fibrillation-AF) among women with breast cancer is becoming a major issue. We aimed at determining the incidence of cardiovascular disease events (AF, arterial and cardiac events, venous-thromboembolism-VTE) in patients diagnosed with breast ca[r]

... 1.3 GDNF receptor complex in neuronal biology Since the discovery of the roles of GDNF in promoting survival and differentiation of midbrain dopaminergic (DA) neurons and increasing the affinity... NT2 into specific neuronal lineages and study the roles of GDNF receptor system in neuronal differ[r]

... sections, role stress concept will be defined first, and the antecedents and consequences of role stress will also be displayed Role Stress The definition of stress conveys the basic idea of a perceived... importance of role stress in managing human resources in service organizations Individual[r]

DOI:http://dx.doi.org/10.7314/APJCP.2014.15.22.9607BRCA1 Promoter Hypermethylation for Detection of Breast Cancer in Viet NamRESEARCH ARTICLEBRCA1 Promoter Hypermethylation Signature for EarlyDetection of Breast Cancer in the Vietnamese Populat[r]