OXIDATIVE STRESS IN THE PATHOGENESIS OF DIABETIC NEPHROPATHY

Oxidative stress plays an important role in the pathogenesis of aging-related osteoporosis through the increased bone resorption or reduced bone formation. Melatonin, which can exert beneficial actions through antioxidant, anti-inflammatory, and bone-preserving effects, shows promise in preventing o[r]

We were able, instead, to quantify a basal oxidative stress when measuring thiobarbituric acid reactive sub- stances (TBARS, nmol/mg protein) level, as a measure of free radical mediated lipid damage. As reported on Figure 5A, LB, HSC93, Jurkat and 1310 cell ’ s TBARS levels wer[r]

610 S. Mondragón-Rodríguez et al.
2.1 Fibrillary Aggregates and Oxidative Stress
Senile plaques and NFTs are also present in a considerable percentage of elderly non-AD brains. Although these markers constitute the criteria for the diagnosis of[r]

Cells were treated with 0.4mM of H2O2 for different periods of time and the levels of p27 were determined by Western blot with actin as a control.. INTERACTION BETWEEN P66SHCA AND P46/52[r]

The present study was carried out with the objectives to study oxidative stress in periparturient cows by estimation of the levels of antioxidant trace elements copper, zinc and iron in plasma at 30, 15 days before parturition, on the day of parturition, 15 and 30 days after parturition.

To evaluate plantar pressure in type 2 diabetic patients. Subjects and methods: 126 type 2 diabetic patients were treated in the National Hospital of Endocrinology (diabetic group); 40 non-diabetic patients (control group).

oxygen we breathe forms free radicals. In an unhealthy state up to 80% of the oxygen we breath forms free radicals.
Oxidative stress
Oxidative stress represents an imbalance between the production and manifestation[r]

The aim of the study was to evaluate the effect of titanium bone fixations on mitochondrial activity, reactive oxygen species (ROS) production, glutathione metabolism, and selected markers of oxidative/nitrosative stress in the periosteum-like tissue of patients treated with mandible fractures.

Reactive oxygen species (ROS), including hydrogen peroxide, drive differentiation of normal fibroblasts into activated fibroblasts, which can generate high amounts of hydrogen peroxide themselves, thereby increasing oxidative stress in the microenvironment.

We evaluated the protective effect of ALS-L1023, an extract of Melissa officinalis L. (Labiatae; lemon balm) against oxidative stress-induced apoptosis in human retinal pigment epithelial cells (ARPE-19 cells).

Diabetic nephropathy (DN) causes the vast proportion of excess mortality for patients with diabetes. Novel therapeutic approaches slowing down its incidence is still lacking. Psoralen is the major active ingredient of Psoralea corylifolia Linn. (PCL), which was used to treat a number of diseases

The addition of 3-BP to TAM caused synergistic effect on the oxidative stress lipid peroxidation in both cell lines and a synergistic effect on glutathione content in MCF-7 but in T47D c[r]

Oxidative phosphorylation is a source of energy production by which many cells satisfy their energy requirements. Endogenous reactive oxygen species (ROS) are by-products of oxidative phosphorylation. ROS are formed due to the inefficiency of oxidative phosphorylation, and lead to oxidative stress t[r]

Diabetic nephropathy (DN) is a major leading cause of kidney failure. Recent studies showed that serological microRNAs (miRs) could be utilized as biomarkers to identify disease pathogenesis; the DN-related miRs, however, remained to be explored.

confluence in 96-well plates and exposed to 100 µ M H 2 O 2 for 16 hours. The plates were then washed 3 times with PBS, and neutrophils (10 5 cells) suspended in EBM-2 medium lacking growth factors were added to HUVECs. The plates were centrifuged at 200 × g for 2 min[r]

Diabetic foot is one of the serious complications of DM and may be the initial presentation of undiagnosed diabetes. Foot problems are associated with significant morbidity and impairment in the diabetic patient’s quality of life. This work aimed at studying the bacteriological profile of diabetic f[r]

of Nrf2 expression. Nrf2 essentially impacts on cell sur- vival of pancreatic ductal epithelial cells by antagonizing the growth inhibitory effect of TGF- β 1 by diminishing TGF- β 1 induced p21 expression and accelerating Erk signaling resulting in increased proli[r]

The literature indicates that red wine presents in its composition several substances that are beneficial to health. This study has investigated the antioxidant effects of Tannat red wine on oxidative stress induced by glucose and fructose in erythrocytes in vitro, with the purpose to determine some[r]

p53R2 is a target of p53 gene, which is essential for DNA repair, mitochondrial DNA synthesis, protection against oxidative stress, chromosomal instability, chronic inflammation and tumorigenesis. This study is aimed to investigate the expression of ribonucleotide reductase (RR) subunit p53R2 in nas[r]

The cell cycle and cellular oxidative stress responses are tightly controlled for proper growth and development of Scots pine (Pinus sylvestris L.) seed. Programmed cell death (PCD) is an integral part of the embryogenesis during which megagametophyte cells in the embryo surrounding region (ESR) and[r]