DNA METHYLATION AND HISTONE MODIFICATIONS REGULATE SOX11 EXPRESSION IN LYMPHOID AND SOLID CANCER CELLS

DNA methylation status of SOX11 in lymphoid and solid tumors
To explore the difference between non-malignant refer- ence tissue and neoplastic cells, we further investigated the methylation status of SOX11 in 42 cell li[r]

Abbreviations
AD: Adenoma; AID: Activation-induced cytidine deaminase;
APC: Adenomatosis polyposis coli; APOBEC: Apolipoprotein B mRNA editing enzyme catalytic subunit; BAX: BCL2 associated X, apoptosis regulator; BHLHE23: Basic helix-loop-helix family member e23; BNC1: Basonuclin; BRAF: B-Raf p[r]

Perez-Burgos L, Kubicek S, Chen T, Li E, Jenuwein T& Peters AH (2003) Suv39h-mediated histone H3 lysine9 methylation directs DNA methylation to major satel-lite repeats at pericentric heterochromatin. Curr Biol 13,1192–1200.78 Rajewsky N (2006) microRNA target prediction[r]

present at a high level in spermatogonia and thendecreases upon further development during mitotic andmeiotic cell d ivisions [19,20]. Neverth eless H1.1 disru ptedmice display no significant phenotype, and show normalspermatogenesis, fertility and testicular morphology [2[r]

alpha-induced low density lipoprotein receptor expression inHepG2 cells. J. Biol. Chem. 273, 15742–15748.18. McDonald, O.B., Chen, W.J., Ellis, B., Hoffman, C., Overton, L.,Rink, M., Smith, A., Marshall, C.J. & Wood, E.R. (1999) Ascintillation proximity assay for the Raf/MEK/ERK[r]

I. Grummt, Molecular Biology of the Cell II,DKFZ-ZMBH Alliance, German CancerResearch Center, Im Neuenheimer Feld581, D-69120 Heidelberg, GermanyFax: +49 6221 423404Tel: +49 6221 423412E-mail: i.grummt@dkfz.de(Received 19 July 2010, revised 16 September2010, accepted 22 September 2010)doi:10.1111/j.[r]

Breast cancer formation is associated with frequent changes in DNA methylation but the extent of very early alterations in DNA methylation and the biological significance of cancer-associated epigenetic changes need further elucidation.

Colorectal cancer (CRC) development is accompanied by changes in expression for several genes; but the details of the underlying regulatory procesess remain unknown. Our aims were to assess the role of epigenetic processes in tumour formation and to identify characteristic DNA methylation and miRNA[r]

Studies have shown that abnormal changes of specific-gene DNA methylation in leukocytes may be associated with an elevated risk of cancer. However, associations between the methylation of the zinc-related genes, WT1 and CA10, and breast cancer risk remain unknown.

in our TMA immunoscreen will help us to identify novelJournal of Translational Medicine 2009, 7:8 http://www.translational-medicine.com/content/7/1/8Page 11 of 15(page number not for citation purposes)TRIP-Br2 expression is dysregulated in many human cancer cell li[r]

Immune surveillance acts as a defense mechanism in cancer, and its disruption is involved in cancer progression. DNA methylation reflects the phenotypic identity of cells and recent data suggested that DNA methylation profiles of T cells and peripheral blood mononuclear cells (PBMC) are altered in c[r]

Thyroid cancer has been indicated to have a higher global proportion of DNA methylation and a decreased level of histone acetylation. Previous studies showed that histone gene reviser and epigenetic changes role significant parts in papillary and anaplastic thyroid cancer tumorigenesis.

BRCA1 promoter methylation has been detected in DNA from peripheral blood cells of both breast cancer patients and cancer-free females. However, the pathological significance of this epigenetic change in white blood cells (WBC) remains an open question.

It has recently been proposed that the M-type phospholipase A2 receptor (PLA2R1) acts as a tumour suppressor in certain malignancies including mammary cancer. Considering that DNA methylation is an important regulator of gene transcription during carcinogenesis, in the current study we analyzed the[r]

Nutrition is believed to be a primary contributor in regulating gene expression by affecting epigenetic pathways such as DNA methylation and histone modification. Resveratrol and pterostilbene are phytoalexins produced by plants as part of their defense system.

KMT2/MLL proteins are commonly overexpressed or mutated in cancer and have been shown to support cancer maintenance. These proteins are responsible for methylating histone 3 at lysine 4 and promoting transcription and DNA synthesis; however, they are inactive outside of a multi-protein complex that[r]

Evidence for general stabilization of mRNAs in response to UV lightFrank Bollig*, Reinhard Winzen*, Michael Kracht, Beniam Ghebremedhin, Birgit Ritter, Arno Wilhelm,Klaus Resch and Helmut HoltmannInstitute of Pharmacology, Medical School Hannover, GermanymRNA stabilization plays an imp[r]

CXCL1 is a chemotactic cytokine shown to regulate breast cancer progression and chemo-resistance. However, the prognostic significance of CXCL1 expression in breast cancer has not been fully characterized. Fibroblasts are important cellular components of the breast tumor microenvironment, and recent[r]

Obesity is a risk factor for colorectal cancer (CRC). Normal and tumor cells respond to metabolic hormones, such as leptin and insulin. Thus, obesity-associated resistance to these hormones likely leads to changes in gene expression and behavior of tumor cells.

Class I histone deacetylases (HDACs) have been reported to be overexpressed in clear cell renal cell carcinoma (ccRCC), whereas the expression of class II HDACs is unknown. Methods: Four isogenic cell lines C2/C2VHL and 786-O/786-OVHL with differential VHL expression are used in our studies. Cobalt[r]