CELL CYCLE; BUDDING YEAST; CDK; DDK; KINETIC MODELLING

as they were the first time. With automated image analysis,objectivit y of the results is guaranteed because the same cri-teria are always used to determine if a feature in the imagerepresents a cell or bud, and the results are therefore easilyreproducible.In budding yeast images[r]

recognition complex. Front. B iosci. 4, D805–D815.5. DePamphilis, M.L. (1999) Replication origins in metazoanchromosomes: fact or fiction? Bioessays 21, 5–16.6. Kelly, T.J. & Brown, G.W. (2000) Regulation of chromosomereplication. Annu.Rev.Biochem.69, 8 29–880.7. Piatti, S., Lengauer, C. &[r]

50:1766-1774.36. Csete ME, Doyle JC: Reverse engineering of biological complexity. Science2002, 295:1664-1669.37. Gould SJ: Ontogeny and Phylogeny Cambridge, MA: Harvard University Press;1977.38. Alberch P, Gould SJ, Oster GF, Wake DB: Size and shape in ontogeny andphylogeny. Paleobiology 1979, 5:29[r]

), and struc-ture solution by molecular replacement is underway.ConclusionWe have shown that, in T. brucei, enolase is present only inthe cytosol. Its expression is developmentally regulated; thespecific cellular activity is 4.5-fold higher in bloodstream-form parasites than in cultured procyclic cel[r]

mitochondria and ribosomes [15,16,54], and several studieshave shown that pro-apoptotic effects of p53 do notnecessarily require transcriptional transactivation activity ofthe protein [55–57].Well documented reports have revealed a role for p53 inthe control of translation of individual mRNA species[r]

Fourier transformation of online gas measurements. This robust mathemat-ical analysis underlined the existence of two types of oscillation. The firstwas found to be linked to the cell cycle because (a) the periodicity corres-ponded to a fraction of the generation time and (b) the oscill[r]

(2003) A positive feedback loop between protein kinaseCKII and Cdc37 promotes the activity of multiple pro-tein kinases. J Biol Chem 278, 2829–2836.29 Miyata Y & Nishida E (2004) CK2 controls multiple pro-tein kinases by phosphorylating a kinase-targeting molec-ular chaperone, Cdc37. Mol [r]

CDK7/cyclin H and CDK9/cyclin T1 complexes may be the critical target of flavopiridol. Phase II clinical trials of flavopiridol are in progress; responses have been reported in chronic lymphocytic leukemia after a dosing schedule was defined to optimize the pharmacokinetics of the drug[r]

that it was even possible to propagate isolated plant cells. Although his experi-ments were of limited success, his merit as the founder of this discipline hasbeen fully acknowledged during this century (see, e.g. Krikorian and Bequam,1969) [6] and quite recently, in 1998, this fact was celebrated i[r]

Song, ZH.; Ji, ZN.; Lo, CK.; Dong, TT.; Zhao, KJ.; Li, OT.; Haines, CJ.; Kung, SD. & Tsim, KW. (2004). Chemical and biological assessment of a traditional chinese herbal decoction prepared from Radix Astragali and Radix Angelicae Sinensis: orthogonal array design to optimize the extraction o[r]

Biomedical Engineering, Trends, Research and Technologies 350 Cheng, XD.; Hou, CH.; Zhang, XJ.; Xie, HY.; Zhou, WY.; Yang, L.; Zhang, SB. & Qian, RL. (2004). Effects of Huangqi (Hex) on Inducing Cell Differentiation and Cell Death in K562 and HEL Cells. Acta Biochimica et Biop[r]

2-DCFDA (n)inthedarkfor45min.Emission spectra were acquired between 500 and 600 nm (excitation at495 nm) for both fluorochromes. Y-axis is the ratio of the maximalemission intensity (at 565 nm for ethidium/DNA complex and 525 nmforDCF)attimet over the value at t ¼ 0, thus representing theincrease rat[r]

FIGURE 9.7 Theoretical model for the generation of neurons and glial cells from stem cellsin the brain. The potential growth factors governing the commitment and differentiation ofthe neuronal lineage are indicated.mucopolysacchaidoses type VII (MPSVII). The enzyme deficiency in this mousemodel cause[r]

induces cell cycle arrest and apoptosis of head and necksquamous cell carcinoma and non-small cell lung cancercells. Clin Cancer Res 2005, 11(19 Pt 1):6924-6932.20. Tsao AS, He D, Saigal B, Liu S, Lee JJ, Bakkannagari S, Ordonez NG,Hong WK, Wistuba I, Johnson FM: Inhibiti[r]

24. Fingerle-Rowson G, Petrenko O: MIF coordinates the cell cycle with DNAdamage checkpoints. Lessons from knockout mouse models. Cell Div2007, 2:22.25. Yeh YH, Huang YF, Lin TY, Shieh SY: The cell cycle checkpoint kinaseCHK2 mediates DNA damage-induced stabilizati[r]

GPI anchoring, and the accumulation of a PI-PLC-resistant, base-labile [3H]inositol-labeled glycolipidwhose glycan headgroup likely contains a single man-nose that is modified with an EthN-P residue.Our epistasis tests with known GPI assemblymutants indicate that Ybr004cp functions in the GPIassembly[r]

24. Fingerle-Rowson G, Petrenko O: MIF coordinates the cell cycle with DNAdamage checkpoints. Lessons from knockout mouse models. Cell Div2007, 2:22.25. Yeh YH, Huang YF, Lin TY, Shieh SY: The cell cycle checkpoint kinaseCHK2 mediates DNA damage-induced stabilizati[r]

cycle progression and its molecular basis were investig ated in the pathogenesis of lung cancer.Methods: Using immunohistochemistry analysis, we analyzed CDK4 protein expression in 89 clinicopathologicallycharacterized lung cancer patients (59 males and 30 females) with ages ranging fr[r]

15. Shaw P, Bovey R, Tardy S, Sahli R, Sordat B, Costa J. Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc Natl Acad Sci 1992; 89:4495-4499. 16. Clarke AR, Gledhill S, Hooper ML, Bird CC, Wyllie AH. p53 dependence of early apoptotic and proliferative resp[r]