Renal cell carcinoma (RCC) incidence is highest in highly developed countries and it is the seventh most common neoplasm diagnosed. RCC management include nephrectomy and targeted therapies. Type 1 insulin-like growth factor (IGF-1) pathway plays an important role in cell proliferation and apoptosis[r]
54. Belfiore A: The role of insulin receptor isoforms and hybrid insulin/IGF-Ireceptors in human cancer. Curr Pharm Des 2007, 13:671-86.55. Pantaleo MA, Nannini M, Di Battista M, Catena F, Biasco G: Combinedtreatment strategies in gastrointestinal stromal tumors (GISTs) afterimatinib a[r]
15. National Heart, Lung, and Blood Institute. Third report of the NationalCholesterol Education Program (NCEP) Expert Panel on detection,evaluation, and treatment of high blood cholesterol in adults (AdultTreatment Panel III). NIH Publication No. 02-5215 2002.16. Matthews DR, Hosker JP, Rudenski AS[r]
15. National Heart, Lung, and Blood Institute. Third report of the NationalCholesterol Education Program (NCEP) Expert Panel on detection,evaluation, and treatment of high blood cholesterol in adults (AdultTreatment Panel III). NIH Publication No. 02-5215 2002.16. Matthews DR, Hosker JP, Rudenski AS[r]
Insulin-like growth factors (IGF´s) play a crucial role in controlling cancer cell proliferation, differentiation and apoptosis. Exercise has been postulated as an effective intervention in improving cancerrelated outcomes and survival, although its effects on IGF´s are not well understood.
Over-expression of insulin-like growth factor 2 mRNA binding protein 3 (IMP3) is correlated with poor prognosis in pancreatic ductal adenocarcinoma (PDAC). Previous studies examining other cancer types have implicated IMP3 in the regulation of several cellular functions that are characteristic of tu[r]
trợ của Sở Khoa học và Công nghệ tỉnh Hậu Giang và Công ty Cổ phần GreenFeed Việt Nam. TÀI LIỆU THAM KHẢO Hoeflich, A., M. Wu, S. Mohan, J. Foll, R. Wanke, T. Froehlich, G.J. Arnold, H. Lahm, H.J. Kolb, E. Wolf (1999). Overex pression of insulin-like growth factor-binding[r]
Cytosolic sialidase (neuraminidase 2; Neu2) is an enzyme whose expressionincreases during myoblast differentiation. Here we show that insulin-likegrowth factor 1 (IGF1)-induced hypertrophy of myoblasts notably increa-ses Neu2 synthesis by activation of the phosphatidylinositol 3-kinase[r]
Resistance towards endocrine therapy is a great concern in breast cancer treatment and may partly be explained by the activation of compensatory signaling pathways. The aim of the present study was to investigate if the insulin-like growth factor-1 receptor (IGF1R) signaling pathway was activated or[r]
Impairment of homologous recombination (HR) is found in close to 50 % of ovarian and breast cancer. Tumors with BRCA1 mutations show increased expression of the Insulin-like growth factor type 1 receptor (IGF-1R). We previously have shown that inhibition of IGF-1R results in growth inhibition and ap[r]
Expression analysis reveals that this IGF-like peptide is predominantlyproduced by the fat body, a functional equivalent of the vertebrate liverand adipocytes, and is massively released during pupa–adult development.Studies using in vitro tissue culture systems show that secretion of thepepti[r]
recombinant fusion protein analogues o f i nsulin-like growth fact or(IGF)-I indicate the relative importance of IG F-binding proteinand receptor binding for enhanced biological potency. J. Mol.Endocrinol. 8, 213±223.27. Francis, G.L., Aplin, S.E., Milner, S.J., McNeil, K[r]
TCNCYH 25 (5) - 2003 Nồng độ hóc môn Insulin-like Growth Factor-I /IGF-I huyết thanh ở trẻ em việt nam - lứa tuổi tiền học đờng Nguyễn Xuân Ninh Khoa Vi chất dinh dỡng - Viện Dinh Dỡng Nghiên cứu đợc tiến hành trên 642 trẻ em lứa tuổi tiền học đờng, nhằm x[r]
In hepatocellular carcinoma (HCC), the third leading cause of cancer-related mortality worldwide, the Child-Turcotte-Pugh score (CTP) is one of the most established tools to assess hepatic reserve and determine survival.
Cancer metastasis is the main contributor to breast cancer fatalities as women with the metastatic disease have poorer survival outcomes than women with localised breast cancers. There is an urgent need to develop appropriate prognostic methods to stratify patients based on the propensities of their[r]
e-mail: chris.mcmahon@agresearch.co.nzRole of IGF-1 in Age-Related Loss of Skeletal Muscle Mass and FunctionChris D. McMahon, Thea Shavlakadze, and Miranda D. Grounds 394 C.D. McMahon et al.1 IntroductionInsulin-like growth factor -1 (IGF-1) is, as the name implies, similar to <[r]
Insulin-like growth factor binding protein 7 (IGFBP7) has been suggested to act as a tumour suppressor gene in various human cancers, yet its role in epithelial ovarian cancer (EOC) has not yet been investigated.
Non-Islet Cell Tumor Hypoglycemia (NICTH) is a rare paraneoplastic cause of hypoglycemia arising from excess tumor production of insulin-like growth factor. The objective of this report is to describe an unusual case of Extragastrointestinal Stromal Tumor (EGIST) associated NICTH.