INSULIN-LIKE GROWTH FACTOR 1

ble in kiAKT cells. Immunoblot analysis was performed using anti-phospho-AKT (Ser473) and anti-phospho-P70S6K (Thr389). The data werenormalized using tubulin as control. (C) Neu2 transcript upregulation is dependent on AKT activity. Neu2 transcript analysis was performedby semiquantitative RT-PCR, u[r]

54. Belfiore A: The role of insulin receptor isoforms and hybrid insulin/IGF-Ireceptors in human cancer. Curr Pharm Des 2007, 13:671-86.55. Pantaleo MA, Nannini M, Di Battista M, Catena F, Biasco G: Combinedtreatment strategies in gastrointestinal stromal tumors (GISTs) afterimatinib a[r]

recombinant fusion protein analogues o f i nsulin-like growth fact or(IGF)-I indicate the relative importance of IG F-binding proteinand receptor binding for enhanced biological potency. J. Mol.Endocrinol. 8, 213±223.27. Francis, G.L., Aplin, S.E., Milner, S.J., McNeil, K.A., B allard,[r]

analysis and interpretation of the data, and writing themanuscript. All authors read and approved the final man-uscript.AcknowledgementsThe authors would like to acknowledge Dr. Molly Yancovitz, Ms. Jennifer Roth, Mr. Jan Zakrzewski, and Ms. Neda Simaika for their assistance in the experiment[r]

FM%r= -0.417p=0.003r= -0.540p<0.001Figure 1 Correlation between IGF-I zSDS (a and b) and IGFBP-1 (c and d), with HS score at ultrasound (US), and FM%. IGF-I zSDS,standard deviation score (SDS) of insulin-like growth factor-I levels according to age; I[r]

their membrane fraction had an IGFBP-rP1-cleaving activity. The mem-brane fraction contained an 80-kDa gelatinolytic enzyme, which wasidentified as the membrane-type serine proteinase matriptase (MT-SP1)by immunoblotting. When the membrane fraction was separated bySDS ⁄ PAGE, the IGFBP-rP1-cleaving a[r]

FM%r= -0.417p=0.003r= -0.540p<0.001Figure 1 Correlation between IGF-I zSDS (a and b) and IGFBP-1 (c and d), with HS score at ultrasound (US), and FM%. IGF-I zSDS,standard deviation score (SDS) of insulin-like growth factor-I levels according to age; I[r]

trợ của Sở Khoa học và Công nghệ tỉnh Hậu Giang và Công ty Cổ phần GreenFeed Việt Nam. TÀI LIỆU THAM KHẢO Hoeflich, A., M. Wu, S. Mohan, J. Foll, R. Wanke, T. Froehlich, G.J. Arnold, H. Lahm, H.J. Kolb, E. Wolf (1999). Overex pression of insulin-like growth factor-binding[r]

Expression analysis reveals that this IGF-like peptide is predominantlyproduced by the fat body, a functional equivalent of the vertebrate liverand adipocytes, and is massively released during pupa–adult development.Studies using in vitro tissue culture systems show that secretion of thepepti[r]

Insulin-like growth factors (IGF´s) play a crucial role in controlling cancer cell proliferation, differentiation and apoptosis. Exercise has been postulated as an effective intervention in improving cancerrelated outcomes and survival, although its effects on IGF´s are not well understood.

enhancement therapies.Another point that dese rves particular mention is thatIGF-II treatment improved significantly lipid metabo-lism, diminishing cholesterol and triglycerides andincreasing free fatty acids circulating levels [6]. Sincefatty acids are synthesized at mi tochondria, th is result isc[r]

from human normal amniotic fluid collected in the weeks 16–18, the intactnonphosphorylated IGFBP-1 and five electrophoretically distinct phospho-isoforms and have determined their in vivo phosphorylation state. Theunmodified protein was the most abundant component and mono-, bi-, tri-and tetraph[r]

RESEARC H Open AccessLiver mitochondrial dysfunction is reverted byinsulin-like growth factor II (IGF-II) in aging ratsMaria Garcia-Fernandez1, Inma Sierra2, Juan E Puche2, Lucia Guerra2and Inma Castilla-Cortazar2*AbstractBackground: Serum IGF-I and IGF-II levels decline[r]

TCNCYH 25 (5) - 2003 Nồng độ hóc môn Insulin-like Growth Factor-I /IGF-I huyết thanh ở trẻ em việt nam - lứa tuổi tiền học đờng Nguyễn Xuân Ninh Khoa Vi chất dinh dỡng - Viện Dinh Dỡng Nghiên cứu đợc tiến hành trên 642 trẻ em lứa tuổi tiền học đờng, nhằm xác định trị số[r]

Technology (Danvers, MA, USA). GSK3b was obtainedfrom BD Transduction Laboratories (San Jose, CA, USA).Tuberin (C-20) and S6K1 (C-18) were obtained from SantaCruz Biotechnology (Santa Cruz, CA, USA). 14.3.3, PanAb-4 (CG15) was obtained from Thermo Scientific (Fre-mont, CA, USA). The ANTI-FLAG polyclo[r]

In hepatocellular carcinoma (HCC), the third leading cause of cancer-related mortality worldwide, the Child-Turcotte-Pugh score (CTP) is one of the most established tools to assess hepatic reserve and determine survival.

calci) hoặc một số lượng tương đương các sản phẩm từ sữa như phô-mai, sữa chua 4. Sữa gây ung thư. Hiện nay có nhiều ý kiến trái ngược về vấn đề này. Một số nghiên cứu kết luận sữa có thể làm giảm nguy cơ ung thư đại tràng trong khi một số khác thì cho rằng sữa có thể làm tăng nguy cơ ung thư vú ở[r]

Bloch, R. J. (2001). Na,K-ATPase in skeletal muscle: two populations of beta-spectrin control localization in the sarcolemma but not partitioning between the sarcolemma and the transverse tubules. Journal of Cell Science, 114, 751–762.393G.S. Lynch (ed.), Sarcopenia – Age-Related Muscle Wasting and[r]

Mechanisms influencing breast cancer (BC) development and recurrence include hyperglycemia, hyperinsulinemia, high insulin-like growth factor-1, high circulating estrogen, inflammation and impaired cellular differentiation/apoptosis. A lifestyle program that targets all the above mechanisms may be w[r]

The insulin-like growth factor (IGF) system plays an important role in the development and progression of cancer. However, little is known about the expression of the IGF system components and their clinicopathological significance and prognostic value in nasopharyngeal carcinoma (NPC).