NOVEL HUMAN PROSTATE EPITHELIAL CELL CULTURE MODELS FOR THE STUDY OF CARCINOGENESIS AND OF NORMAL ST...

At present, many types of primary cancer stem cellswith specific surface mark ers have been isolated and thecancer stem cell hypothesis is widely accepted. However,many questions remain in the field of cancer stem cellsresearch. <[r]

Several physiological (fertilization, placentation, wound healing) and pathophysiological processes (infection with enveloped viruses, cancer) depend on cell fusion.

collected in most circumstances, leads to rapid and sustained engraftment in virtually all cases. Compared to the use of autologous marrow, use of peripheral blood stem cells results in more rapid hematopoietic recovery, with granulocytes recovering to 500/µ[r]

Development and further characterization of animal models for human cancers is important for the improvement of cancer detection and therapy. Canine bladder cancer closely resembles human bladder cancer in many aspects. In this study, we isolated and characterized four primary transitional cell carc[r]

, vols 1 and 2. London, Elsevier Academic Press, 2004 Marshak DR et al (eds): Stem Cell Biology, New York, Cold Spring Harbor Laboratory Press, 2001 Odorico J et al (eds): Human Embryonic Stem Cells. New York, BIOS Scientific Publishers, 2005

Glioma stem cells (GSCs) contribute to tumor recurrence and drug resistance. This study characterizes the tumorigenesis of CD133+ cells and their sensitivity to pharmacological inhibition.

Adult stem cells are crucial for maintaining proper function and repair of tissues. The epithelium of the adult mammalian intestine is a constant dialog with its underlying mesenchyme to direct progenitor proliferation, lineage commitment, terminal differentiation and ultimately cell death. The epit[r]

The presence of tumor supporting cells in various cancer, including in hepatocellular carcinoma (HCC), has become an important target in the study of carcinogenesis. The cancer-associated fibroblast (CAF), one of the most important cellular components in the cancer stroma, might contribute to the pr[r]

2. Pecorelli S, Favalli G, Zigliani L, Odicino F: Cancer in women. Int JGynaecol Obstet 2003, 82:369-379.3. Godwin AK, Testa JR, Hamilton TC: The biology of ovarian can-cer development. Cancer 1993, 71:530-536.4. Ness RB, Cottreau C: Possible role of ovarian epi[r]

Three-dimensional (3-D) cultures of cancer cells can potentially bridge the gap between 2-D drug screening and in vivo xenografts. The objective of this study was to characterize the cellular and extracellular matrix characteristics of spheroids composed of human lung epithelial cells (epi), pulmona[r]

Cancer stem cells are hypoxia-resistant and present a preponderant glycolytic metabolism. These characteristics are also found in basal-like breast carcinomas (BLBC), which show increased expression of cancer stem cell markers.

Studies over the past decade and half have identified cancer stem cells (CSCs) to be responsible for tumorigenesis, invasion, sustenance of metastatic disease, radio- and chemo-resistance and tumor relapse. Recent reports have described the plasticity of breast CSCs (BCSCs) to shift between the epit[r]

Epithelial-to-mesenchymal transition (EMT) and cancer stem cells (CSC) contribute to tumour progression and metastasis. Assessment of transcription factors involved in these two mechanisms can help to identify new targets for an oncological therapy. In this study, we focused on the evaluation of the[r]

Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 1) Harrison's Internal Medicine &gt; Chapter 67. Applications of Stem Cell Biology in Clinical Medicine Applications of Stem Cell Biology in Clinical Medicine[r]

production during development, but for most of human life it is located in the bone marrow. Within the bone marrow, at least two niche sites have been proposed: on trabecular bone surfaces and in the perivascular space. Stem cells may be[r]

There are some technical issues to consider with stud- ies of genomic alterations in small amount of cells as performed in the present study. One such matter is that CD133+ cells are few within tumours. Therefore, whole genome amplification (WGA) was necessa[r]

Cancer stem cells (CSCs) are considered the cell subpopulation responsible for breast cancer (BC) initiation, growth, and relapse. CSCs are identified as self-renewing and tumor-initiating cells, conferring resistance to chemo- and radio-therapy to several neoplasias. Nowadays, th (about 10mM)e phar[r]

Private health companies will patent procedures andfix their own prices for treatment. Is this acceptable?✁Student AEmbryonic stem cells: These are the first cells of life, found in a newly fertilisedhuman egg. Each embryonic stem cell has t[r]

FoxO3 can localize to the nucleus and regulate expressionof Bim and FasL, w hich play an important role i n apoptoticcell death in HSCs [51-54]. The 14-3-3 protein was alsofound in stem cell disease using the proteomics approach[55]. The invest[r]

It has recently been proposed that the M-type phospholipase A2 receptor (PLA2R1) acts as a tumour suppressor in certain malignancies including mammary cancer. Considering that DNA methylation is an important regulator of gene transcription during carcinogenesis, in the current study we analyzed the[r]