MOLECULAR BIOLOGY OF CANCER STEM CELLS

Adult stem cells are crucial for maintaining proper function and repair of tissues. The epithelium of the adult mammalian intestine is a constant dialog with its underlying mesenchyme to direct progenitor proliferation, lineage commitment, terminal differentiation and ultimately cell death. The epit[r]

.. .GENERATION OF PORCINE INDUCED PLURIPOTENT STEM CELLS AND THEIR DIFFERENTIATION INTO CARDIAC LINEAGES TAN WAN CHIU GRACE (B.Eng.(Hons.), NTU) A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF. .. generate porcine induced pluripotent stem cells (IPSCs) from porcine fibroblast cells and differentiate[r]

.. .EFFECTS OF HIGH GLUCOSE CONCENTRATIONS ON THE EXPRESSION OF GENES INVOLVED IN PROLIFERATION AND CELL- FATE SPECIFICATION OF MOUSE EMBRYONIC NEURAL STEM CELLS FU JIANG (MD, MMed) A THESIS... Illustration Schematic summary of the effects of high glucose on the expression of developmental control g[r]

Practical and laboratory diagnosis of tuberculosis from sputum smear to molecular biology 2015
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Scientists take stem cells from an aborted foetus fortheir research. Is this acceptable?2A two-year-old boy has a rare blood disease andneeds a blood donor to save him. None of hisbrothers’ or sisters’ blood is an exact match.Through genetic diagnosis, scientists are able to tel[r]

division, Chapter 5). Chromosomes contain DNA, which isorganised into functional units called genes. Genes controlthe activities of the cell and inheritance; thus the nucleuscontrols the cell’s activities. When a cell is about to divide,the nucleus divides first so that each new cell will hav[r]

... types for developing in vitro models for predicting organ- specific toxicity Immortalized cell lines such as the standard murine fibroblast cell line NIH/3T3 are commonly used in toxicity testing... human 18 induced pluripotent stem cell (hiPSC)-derived HPTC-like cells for the development of in[r]

The enrichment of cancer stem cell-like cells (CSCs) has been considered to be responsible for tumor progression after an initial response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKIs) in patients with non-small cell lung adenocarcinoma (NSCLC/ADC). CSCs with ALDH[r]

Circular RNAs (CircRNAs) are biologically active RNAs. CDR1as is one such circRNA previously reported to be a microRNA-7 (miR-7) sponge, thereby regulating associated gene expression. The specific underlying molecular mechanisms of CDR1as biology, however, remain largely unknown.

Several physiological (fertilization, placentation, wound healing) and pathophysiological processes (infection with enveloped viruses, cancer) depend on cell fusion.

... 1.3 GDNF receptor complex in neuronal biology Since the discovery of the roles of GDNF in promoting survival and differentiation of midbrain dopaminergic (DA) neurons and increasing the affinity... NT2 into specific neuronal lineages and study the roles of GDNF receptor system in neuronal differ[r]

... 1 .3. 4 Other regulatory mechanisms 30 1 .3. 5 Apoptosis and cancer 30 1 .3. 6 TRAIL signaling pathway as potential therapeutic target 32 Objectives of the study Chapter Materials and Methods 33 34 ... accompanying p 53 up-regulation 51 3. 4 I3M causes Bid cleavage 55 3. 5 I3M induces Bax confor[r]