BÁO CÁO SINH HỌC: "COMPOUND DEVELOPMENTAL EYE DISORDERS FOLLOWING INACTIVATION OF TGF SIGNALING IN NEURAL-CREST STEM CELLS" DOC

avascular and transparent secondary vitreous [17]. Inpatients with congenital persistent hyperplastic primaryvitreous, developmentally abnormal primary vitreousbecomes a fibro-vascular membrane, formed behind thelens (retrolentally) [18]. Much as in human persistenthyperplastic primary vitreo[r]

cal functions remain to be elucidated for the other fusion partners. Thisminireview tries to sum up some of the available data and mechanismsidentified in leukemic stem and leukemic tumor cells and link this informa-tion with the known functions of mixed lineage leu[r]

REVIE W Open AccessTargeting the osteosarcoma cancer stem cellValerie A Siclari, Ling Qin*AbstractOsteosarcoma is the m ost common type of solid bone cancer and the second leading cause of cancer-relateddeath in pediatric patients. Many patients are not cured by the curre[r]

Email: Zhaohui Zhong - jzhonguro@gmail.com; Amit N Patel - dallaspatel@gmail.com; Thomas E Ichim* - thomas.ichim@gmail.com; Neil H Riordan - nhriordan@gmail.com; Hao Wang - hwang1@uwo.ca; Wei-Ping Min - weiping.min@uwo.ca; Erik J Woods - Erik@gnrlbiotech.com; Michael Reid - mreidnd@gmail.com; Eduard[r]

designed and edited the manuscript. All authors read andapproved the manuscript.Additional materialAcknowledgementsThe human ES cell (HES-3) was provided by ES cell International Pre Ltd, Singapore. This work was supported by grants from Japanese Ministry of Education, Culture, Sports, Scienc[r]

therapeutics on normal stem cells to ensure a l imitedamount of non-specific toxicity. Further understandingof the osteosarcoma CSC will aid in determining how totarget it. Microarray analyses can determine genes thatare upregulated in the osteosarcoma CSC compared[r]

up-regulated genes included lysyl oxidase (Lox) and nerve growth factor receptor associated protein 1 (Ngfrap1),which are important in the regulation of protein-lysine 6-oxidase activity, and in apoptosis induction, respectively.The down-regulated genes included glycoprotein-4-b[r]

Pellorce, C. Leberre, L. Preisser, H. Gascan &M. Samson, unpublished data). Taken altogether, theresults suggest that multiple pathways are involved inprokineticin signaling in monocytes, and that theremight be some species-to-species variation.Furthermore, another molecular me[r]

Received: 2010.07.05; Accepted: 2010.09.07; Published: 2010.09.10 Abstract Introduction. Anisocoria indicates a difference in pupil diameter. Etiologies of this clinical manifestation usually include systemic causes as neurological or vascular disorders, and local causes as cong[r]

Genet 12, 1699–1711.23 Dirsch VM, Gerbes AL & Vollmar AM (1998) Ajoene,a compound of garlic, induces apoptosis in humanpromyeloleukemic cells, accompanied by generation ofreactive oxygen species and activation of nuclear factorkappaB. Mol Pharmacol 53, 402–[r]

Inhibition of PI3K/Akt partially leads to the inhibition ofPrPC-induced drug resistance in gastric cancer cellsJie Liang*, Fulin Ge*, Changcun Guo, Guanhong Luo, Xin Wang, Guohong Han, Dexin Zhang,Jianhong Wang, Kai Li, Yanglin Pan, Liping Yao, Zhanxin Yin, Xuegang Guo, Kaichun Wu, Jie[r]

IL-1βTNF-αTSST-1SPE AIL-6IL-8MIP-3αIL-6IL-8MIP-3αFig. 2. Outside-in signaling from SAgs at mucosal surfaces leads to TSS: proposed models. In the case of Staphylococcus aureus, bacteriaremain localized on the vaginal epithelium but secrete cytolysins, such as a-toxin, whi[r]

graft could be an alternative nerve graft [2,7,21]. Nerveallograft may act as a temporary scaffold across which hostaxons regenerate.Natural or synthetic nerve guides were being developedand employed as alternatives to autografts in bridgingnerve gap defects [9,22,24]. It was suggested that t[r]

27. Tan J, Town T, Mullan M: CD45 inhibits CD40L-induced micro-glial activation via negative regulation of the Src/p44/42MAPK pathway. J Biol Chem 2000, 275:37224-37231.28. Tan J, Town T, Paris D, Mori T, Suo Z, Crawford F, Mattson MP, Fla-vell RA, Mullan M: Microglial activation resulting fr[r]

tumor suppressor genes wo uld lead to prostatecarcinogenesis.Additionally, Barker et al [72] and Zhu et al [43] dis-covered crypt stem cells as the origin of intestinal can-cer. They demonstrated that Lgr5 positive or prominin1positive subpopulations were intesti nal stem[r]

26. Harris MH, Thompson CB: The role of the Bcl-2 family in the regulation ofouter mitochondrial membrane permeability. Cell Death andDifferentiation 2000, 7(12):1182-1191.27. Opferman JT, Korsmeyer SJ: Apoptosis in the development andmaintenance of the immune system. Nat[r]

Piangitjagum A, Wasi P, Ma L, Schrier SL: A correlation of erythrokinetics,ineffective erythropoiesis, and erythroid precursor apoptosis in thaipatients with thalassemia. Blood 2000, 96(7):2606-2612.8. Kong Y, Zhou S, Kihm AJ, Katein AM, Yu X, Gell DA, Mackay JP, Adachi K,Foster-Brown[r]

AP-2a [64,67].Reports on AP-2a knockout mice clearly indicatethe importance of this transcription factor in regulat-ing bone and cartilage development during embryogen-esis, because of the severe skeletal defects in growthand the development of face and limbs [17–1[r]

At present, many types of primary cancer stem cellswith specific surface mark ers have been isolated and thecancer stem cell hypothesis is widely accepted. However,many questions remain in the field of cancer stem cellsresearch. For example, where primary ca[r]

AbstractThe dystrophin gene, located at Xp21, codifies dystrophin, which is part of a protein complexresponsible for the membrane stability of muscle cells. Its absence on muscle causes DuchenneMuscular Dystrophy (DMD), a severe disorder, while a defect of muscle dystroph[r]