DISCOVERY OF CYCLOPHILIN INHIBITOR NIM811 AS A NOVEL THERAPEUTIC AGENT FOR HCV

Nanomedicine is a very promising field and nanomedical drugs have recently been used as therapeutic agents against cancer. In a previous study, we showed that Nanoceria (NCe), nanoparticles of cerium oxide, significantly inhibited production of reactive oxygen species, cell migration and invasion of[r]

Metformin, which is widely used as an antidiabetic agent, has recently been reported to reduce cancer risk and improve prognosis in certain malignancies. However, the specific mechanisms underlying the effect of metformin on the development and progression of several cancers including oral squamous[r]

Chk1 inhibitors are currently in clinical trials as putative potentiators of cytotoxic chemotherapy drugs. Chk1 inhibitors may exhibit single agent anti-tumor activity in cancers with underlying DNA repair, DNA damage response or DNA replication defects.

Increasingly, the role of chronic inflammation and its mediators in tumor generation and progression is gaining importance in the field of cancer research. In this context, candidature of non steroidal anti-inflammatory drugs (NSAIDs) as potential anti-tumor therapeutic agent is being evaluated glob[r]

Iron is essential for cell replication, metabolism and growth. Because neoplastic cells have high iron requirements due to their rapid proliferation, iron depletion may be a novel therapeutic strategy for cancer. Deferasirox (DFX), a novel oral iron chelator, has been successful in clinical trials i[r]

Metastatic or relapsed angiosarcoma has a poor prognosis and the efficacy of conventional chemotherapy is often limited. Apatinib, a novel tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptor-2 (VEGFR2), has been approved for the treatment of advanced gastric cancer.

Oesophageal squamous cell carcinoma (OSCC) is a major health burden in Sub-Saharan Africa, and novel chemotherapies are urgently required to combat this disease. The heat shock protein 90 (HSP90) inhibitor 17-N-allylamino-17-demethoxygeldanamycin (17-AAG) has previously been proposed as a possible c[r]

TRANG 14 xii The Legal and Economic Implications of Electronic Discovery: Options for Future Research PROPOSED RESEARCH AGENDA Because e-discovery will affect litigation outcomes within a[r]

Hepatitis C treatment is currently facing many challenges, such as high costs of medicines, side effects in patients, and low success rates with Hepatitis C Virus genotype 1b (HCV-1b). In order to identify what characteristics of HCV-1b cause drug resistance, many sequence analysis methods are condu[r]

... Influence of Recommendation Agent • Trust Electronic Recommendation Agent, Decision Support System, The consumer-centric double agent perspective provides a framework for the design of product recommendation. .. acceptance of current agent advice Haübl and Murray (2003) Constructs used 14 Author[r]

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies today with an urgent need for novel therapeutic strategies. Biomarker analysis helps to better understand tumor biology and might emerge as a tool to develop personalized therapies.

TRANG 1 DESIGN AND CHARACTERISTICS OF A NOVEL COMPLIANT PLANAR SPRING CAPABLE OF A POSITIVE STIFFNESS FOR A COMPACT VIBRATION ISOLATOR _THIẾT KẾ VÀ ĐẶC TÍNH CỦA LÒ XO PHẲNG MỀM MỚI CHO B[r]

Discovery and preclinical evaluation of novel dopamine partial agonists as antipsychotic agents Discovery and preclinical evaluation of novel dopamine partial agonists as antipsychotic agents Discovery and preclinical evaluation of novel dopamine partial agonists as antipsychotic agents Discovery an[r]

This paper investigates the mechanical and thermal properties of styrene butadiene rubber (SBR) using dicumyl peroxide as curing agent. The results showed that the tear strength of SBR with 2 phr DCP as curing agent increased sharply from 31,7 N/mm to 73,2 N/mm compared to SBR cured with sulfur.

Exosomes or extracellular vesicles have the potential as a diagnostic marker for various diseases including cancer. In order to identify novel exosomal markers for prostate cancer (PC), we performed proteomic analysis of exosomes isolated from PC cell lines and examined the usefulness of the marker[r]

Novel non-invasive biomarkers for gastric cancer (GC) are needed, because the present diagnostic methods for GC are either invasive or insensitive and non-specific in clinic. The presence of stable circulating microRNAs (miRNAs) in plasma suggested a promising role as GC biomarkers.

... convergence and accuracy have been achieved through our method The MoM algorithm is next used to design and analyze novel bandpass filters Several miniaturization techniques for bandpass filter design. .. made of filter structures, there is a need to investigate miniaturization of the filters Fi[r]

Procedures for controlling the false discovery rate (FDR) are widely applied as a solution to the multiple comparisons problem of high-dimensional statistics. Current FDR-controlling procedures require accurately calculated p-values and rely on extrapolation into the unknown and unobserved tails of[r]

Bioenergy systems for the future 5 anaerobic biodigestion for enhanced bioenergy generation in ethanol biorefineries understanding the potentials of vinasse as a biofuel Bioenergy systems for the future 5 anaerobic biodigestion for enhanced bioenergy generation in ethanol biorefineries understan[r]

The polyspecific organ cation transporter 1 (OCT1) is one of the most important active influx pumps for drugs like the kinase inhibitor sorafenib. The aim of this retrospective study was the definition of the role of intratumoral OCT1 mRNA expression in hepatocellular carcinoma (HCC) as a biomarker[r]