THE PYRUVATE DEHYDROGENASE COMPLEX IN CANCER IMPLICATIONS FOR THE TRANSFORMED STATE AND CANCER

... 1.3 GDNF receptor complex in neuronal biology Since the discovery of the roles of GDNF in promoting survival and differentiation of midbrain dopaminergic (DA) neurons and increasing the affinity... NT2 into specific neuronal lineages and study the roles of GDNF receptor system in neuronal differ[r]

Primary debulking surgery (PDS) and adjuvant chemotherapy is the standard treatment for advanced ovarian, fallopian or primary peritoneal cancer.

... interaction for intracellular uptake after the nanocarriers reach the target site from blood circulation and extravasation There are advantages and drawbacks for each of this strategy that will... and Y Y Yang, “Advanced Materials for Co -Delivery of Drugs and Genes in Cancer Therapy,” Advanced[r]

Caregiving for childhood cancer survivors may be burdensome for caregivers and affect their physical health and health behaviors. However, studies examining health behaviors in caregivers of childhood cancer survivors are scarce.

Neoadjuvant therapy plus oesophagectomy has been accepted as the standard treatment for patients with potentially curable locally advanced oesophageal cancer. No completed randomized controlled trial (RCT) has directly compared neoadjuvant chemotherapy and neoadjuvant chemoradiation in patients with[r]

INTRODUCTION OF THESIS

1. Background:
Lung cancer is one of the common cancers. The disease has the highest incidence and mortality among cancers, most commonly seen in the elderly especially over 60 years old. The majority of lung cancer is related to secondhand and passive smoking and has over[r]

Vietnamese population, has considerably increased witha faster pace over past decades (Nguyen et al., 2013).Therefore, the purpose of present study was to investigatethe methylation status of BRCA1 gene’s promoter in breastcancer tumor in Vietnamese population. The methyl[r]

Syntax puts our meaning (“semantics”) into sentences, and phonology puts the sentences into the sounds that we hear and there must, surely, be a structure in the meaning that is expressed in the syntax and phonology. Some writers use the phrase “semantic structure”, but are referring to conceptual s[r]

To evaluate the efficiency of endobronchial ultrasound for diagnosis of patients with suspected lung cancer. Subjects and methods: 82 patients with suspected primary lung cancer, treated at 103 Military Hospital and K3 Hospital located at Tan Trieu, Thanh Tri, Hanoi from January, 2013 to October, 20[r]

having to know very much about cancer or cancer research,becausebasicallythequestion is about money: government as against private spending on health, orthe priorities in health spending in caseswhere funds are limited.These kinds of ideas can also be brainstormed by jott[r]

On the basis of chemical and spectral analyses, the fucoidan fractions obtained were found to be the sulfated fucogalactans containing sulfate ester groups and uronic acid, and composed essentially of fucose and galactose, as well as a minor amount of other sugars. The polysaccharide fractions were[r]

The purpose of this study was to assess the efficacy and safety of cisplatin-based chemotherapy with or without bevacizumab (BEV) in Chinese women with advanced cervical cancer (ACC).

Conversion surgery (CS) following a response to chemotherapy occasionally leads to prolonged survival in patients with stage IV gastric cancer (GC). This study aimed to evaluate the predictive value of the neutrophil/lymphocyte ratio (NLR) for the success of CS in patients with stage IV GC.

Research and cancer care are closely intertwined; however, it is not clear whether physicians and nurses believe that clinical trials offer the best treatment for patients and, if so, whether this belief is justified.

Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide. The only drug currently approved for clinical use in the treatment of advanced HCC is sorafenib. However, many patients with HCC show reduced sensitivity to sorafenib during treatment.

A RNA sequencing dataset (the training set) and a microarray dataset (the validation set) were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database, respectively. Differentially expressed genes (DEGs) between metastatic and non-metastatic OS samples were identified[r]

The prognostic nutritional index (PNI), an immunity and nutrition based prognostic score, was correlated with clinical outcomes in different tumors. However, the prognostic significance of PNI has not been investigated in hormone sensitive prostate cancer (PCa).

Ramucirumab monotherapy as a second-line treatment for advanced gastric cancer (AGC) prolongs survival compared to the best supportive care. However, in clinical practice, ramucirumab monotherapy is sometimes used as third- or later-line treatment for AGC refractory to fluoropyrimidine and taxanes.

patient's life time. In Vietnam, there areseveral studies about chemoradiotherapyin the treatment of esophageal cancer,such as the study of Han Thanh Binh in2004, Nguyen Duc Loi in 2015, but thesestudies were limited to 2D radiotherapyand 60 Gy high dose radiation[r]

Concern for cardiovascular disease (particularly atrial fibrillation-AF) among women with breast cancer is becoming a major issue. We aimed at determining the incidence of cardiovascular disease events (AF, arterial and cardiac events, venous-thromboembolism-VTE) in patients diagnosed with breast ca[r]