SRC ESTROGEN RECEPTORS AND RECEPTOR TYROSINE KINASES IN BREAST CANCER

B. Madhu Krishna 1 , Sanjib Chaudhary 1,2 , Dipti Ranjan Mishra 3 , Sanoj K. Naik 1 , S. Suklabaidya 4 , A. K. Adhya 5 and Sandip K. Mishra 1*
Abstract
Background: Breast cancer (BC) is highly heterogeneous with ~ 60 – 70% of estrogen receptor positive BC patie[r]

Orphan nuclear receptors ERRα, ERRβ and ERRγ that belong to NR3B or type IV nuclear receptor family are well studied for their role in breast cancer pathophysiology. Their homology with the canonical estrogen receptor dictates their possible contributing role in mammary gland development and disease[r]

Cancer stem cells (CSCs) are believed to promote the malignant transformation of breast cancer via multiple signaling pathways, including the Wnt/β-catenin pathway. Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) has been identified as a CSC-associated Wnt-regulated target gene, b[r]

Tamoxifen treatment of estrogen receptor (ER)-positive breast cancer reduces mortality by 31%. However, over half of advanced ER-positive breast cancers are intrinsically resistant to tamoxifen and about 40% will acquire the resistance during the treatment.

The receptor CXCR4 and its ligand CXCL12 play crucial roles in breast cancer. Despite the fact that the spontaneous feline mammary carcinoma (FMC) is considered a suitable model for breast cancer studies, the importance of the CXCR4/CXCL12 axis in FMC is completely unknown.

sis, endothelial phenotype, and function. Trends Cardio-vasc Med 13, 276–282.J. Monnier and M. Samson Cytokine properties of prokineticinsFEBS Journal 275 (2008) 4014–4021 Journal compilation ª 2008 FEBS. No claim to original French government works 401911 Kaser A, Winklmayr M, Lepperd[r]

VO4. Immunoprecipitated S6Ks were tested with anti-pY IgG and membrane wasreprobed with S6K antibody. Total lysate was also analyzed for src expression. (E) The activity of S6K1 ⁄ 2 Y39F ⁄ Y45F mutants is not altered.Hek293 cells were transfected with S6K1 ⁄ 2 or Y39F ⁄ 45F. Cells were[r]

Chapter 081. Principles of Cancer Treatment (Part 19) Solid Tumors Small-molecule epidermal growth factor (EGF) antagonists act at the ATP binding site of the EGF receptor tyrosine kinase. In early clinical trials, gefitinib showed evidence of responses in a small[r]

significantly elevated by knockdown of endogenousmiR-22 in MDA-MB-231 cells that expressed a rela-tively high level of miR-22. These results demonstratethat ERa is a direct target of miR-22. miR-22 treatmentwas found to dramatically reduce the endogenous trans-lational yield of ERa, and[r]

value in cancer. This review will discuss recent information on thebiochemical, proteomics and immunological characterization of ENOA,particularly its ability to trigger a specific humoral and cellular immuneresponse. In our opinion, this information can pave the wa[r]

The role of forkhead-box A1 (FOXA1) and Androgen receptor (AR) in breast cancer (BC) has been extensively studied. However, the prognostic role of their co-expression in Estrogen receptor positive (ER+) BC has not been investigated so far.

affecting the forearms, but it has also been associated with fingernail ridging, breakdown, and skin discoloration. Stomatitis appears to be somewhat more frequent than with paclitaxel. Estramustine was originally synthesized as a mustard derivative that might be useful in neoplasms th[r]

To clarify the effect of anaesthetic agents on cancer immunity, we evaluated the effects of propofol and sevoflurane on natural killer (NK) cell, cytotoxic T lymphocyte (CTL) counts and apoptosis rate in breast cancer and immune cells co-cultures from patients who underwent breast cancer surgery.

Chapter 080. Cancer Cell Biology and Angiogenesis (Part 10) Estrogen receptors (ERs) and androgen receptors, members of the steroid hormone family of nuclear receptors, are targets of inhibition by drugs used to treat breast and prostat[r]

miRNA expression is regulated by upstream regula- tors. Previous study has showed that there is a negative feedback regulation of miR-590 and ATF-3 in breast cancer. Inhibition of ATF-3 significantly upregulated the expression of miR-590 [ 27 ]. In this study we fo[r]

Previously, we have shown that miR-18a and miR-18b gene expression strongly correlates with high proliferation, oestrogen receptor -negativity (ER− ), cytokeratin 5/6 positivity and basal-like features of breast cancer.

It is unclear whether germline breast cancer susceptibility gene mutations affect breast cancer related outcomes. We wanted to evaluate mutation patterns in 20 breast cancer susceptibility genes and correlate the mutations with clinical characteristics to determine the effects of these germline muta[r]

neidge, S.A. (1995) DNA synthesis induced by some but not allgrowth factors requires Src family protein tyrosine kinases. Mol.Cell. Biol. 15, 1102–1109.24. Laemmli, U.K. (1970) Cleavage of structural proteins during theassembly of the head of bacteriophage T4. Nature 227,680–685[r]

Lymph node metastasis is more likely in early-stage breast cancer with lower tumor-infiltrating lymphocyte (TIL) density. Therefore, we investigated the correlation between TILs and lymph node metastasis in cT1 breast cancer patients undergoing surgery and the usefulness of TILs in predicting sentin[r]

Chapter 080. Cancer Cell Biology and Angiogenesis (Part 9) Acetylation of the amino terminus of the core histones H3 and H4 induces an open chromatin conformation that promotes transcription initiation. Histone acetylases are components of coactivator complexes recruited to pro[r]