DNA METHYLATION IN PROMOTER REGION AS BIOMARKERS IN PROSTATE CANCER

In the AD versus NAT comparison, 94% of the top50 highly methylated DMRs were found in CpG islands
including generally known CRC-associated DNA methy- lation markers like Fli-1 proto-oncogene, ETS transcrip- tion factor ( FLI1 ), GATA binding protein 4 ( GATA4 ) and nerve grow[r]

3In other words, a treatment needs to be potent forits effects to be statistically significant in a smaller sample. Whilethere is not a direct correlation between change in PSA and differ-ences in progression or survival, PSA is used as a primary end pointmeausre o[r]

and manuscript preparation. All of the authors read and approved the finalmanuscript.Competing interestsThe authors declare that they have no competing interest s.Received: 19 November 2010 Accepted: 28 April 2011Published: 28 April 2011References1. Folk JE: Transglutaminases. Annu Rev Biochem 1980,[r]

modulated during human melanoma differentiation, growth andprogression. Oncogene 1995, 11:2477-2486.17. Jiang H, Su ZZ, Lin JJ, Goldstein NI, Young CSH, Fisher PB: The melanomadifferentiation associated gene mda-7 suppresses cancer cell growth.Proc Nat Acad Sci USA 1996, 93:9160-9165.18. Lebe[r]

Novel non-invasive biomarkers for gastric cancer (GC) are needed, because the present diagnostic methods for GC are either invasive or insensitive and non-specific in clinic. The presence of stable circulating microRNAs (miRNAs) in plasma suggested a promising role as GC biomarkers.

Current diagnostic tools for prostate cancer lack specificity and sensitivity for detecting very early lesions. DNA methylation is a stable genomic modification that is detectable in peripheral patient fluids such as urine and blood plasma that could serve as a non-invasive diagnostic biomarker for[r]

microRNAs (miRNAs) are considered promising cancer biomarkers, showing high reliability, sensitivity and stability. Our study aimed to identify associations between whole blood miRNA profiles, presence of circulating tumor cells (CTCs) and clinical outcome in post-operative early breast cancer patie[r]

these enzymes and provides a mechanistic basis for thefunctional cooperation of different DNA MTases in de novomethylation of DNA that has also been observed in vivo.Keywords: DNA methylation; enzyme mechanism; DNAmethyltransferase; Dnmt1; Dnmt3a.Cytosine res[r]

High circulating tumor cell (CTC) counts are associated with poor prognosis in advanced prostate cancer, and recently CTC number was suggested to be a surrogate for survival in metastatic castrate-resistant prostate cancer (mCRPC).

In this retrospective study, we evaluated the biochemical recurrence rate, metastatic disease progression, and prostate cancer-specific and overall survival in patients curatively treated with external beam radiotherapy (EBRT) for early prostate cancer (PC).

cytokines that may induce macrophage activation, B-celltively. In addition, APC can also take up antigen-ladenproliferation and immunoglobulin secretion [59,60] . Theapoptotic bodies of transfected myocytes (or other cells)and present the relevant peptides on MHCs ( Fig. 1 ). CpG DNA c[r]

(A) Schematic presentation of the location of the primers used forRT-PCR and qRT-PCR studies. GAPDH was used as a control andthe primers were designed to allow the determination of contami-nating genomic DNA. RT-PCR (B) and qRT-PCR (C) were performedwith primer pair I to analyse Fas mR[r]

We aimed to evaluate the correlation between p16ink4a-overexpression and high risk (hr)HPV-DNA in vulvar squamous cell carcinoma (vSCC) tumors as well as the impact of both biomarkers on the prognosis of vSCC patients.

To evaluate the efficacy of cetuximab combined with modified FOLFIRI (mFOLFIRI) as a second-line treatment in metastatic gastric cancer patients and to identify potential biomarkers of clinical outcomes

The bone scan index (BSI), which is obtained using a computer-aided bone scan evaluation system, is anticipated to become an objective and quantitative clinical tool for evaluating bone metastases in prostate cancer. Here, we assessed the usefulness of the BSI as a prognostic factor in patients with[r]

failed to detect the virus in cohorts of prostate cancer patients [5-9]. Very recently, Paprotka et al. (2011) have challenged an association of XMRV with human diseases [10]. These authors have reported that XMRV may have originated by a rare recombination event during tumor pa[r]

The total intake of dietary antioxidants may reduce prostate cancer risk but available data are sparse and the possible role of supplements unclear. We investigated the potential association between total and dietary antioxidant intake and prostate cancer in a Swedish population.

Platinum-based chemotherapy is emerging as the first line of treatment for castration resistant prostate cancer. Among the family of platinum (IV)-based compounds, a member known as CPA-7 inhibits the growth of multiple cancer cell lines. However, how and to what extent CPA-7 elicits its anti-prosta[r]

Aberrant Wnt signaling activation occurs commonly in colorectal carcinogenesis, leading to upregulation of many target genes. APC (adenomatous polyposis coli) is an important component of the β-catenin destruction complex, which regulates Wnt signaling, and is often mutated in colorectal cancer (CRC[r]

TMPRSS2:ERG fusions are frequent in prostate cancer, and occur predominantly in young patients. Several studies had proposed intratumoral heterogeneity of these fusions. This study was designed to determine frequency and extent of ERG fusion heterogeneity in early-onset prostate cancer (EO-PCA,