EML4-ALK INDUCES CELLULAR SENESCENCE IN MORTAL NORMAL HUMAN CELLS AND PROMOTES ANCHORAGE-INDEPENDENT GROWTH IN HTERT-TRANSDUCED NORMAL HUMAN CELLS - TRƯỜNG ĐẠI HỌC HỒNG ĐỨC
Tìm thấy 10,000 tài liệu liên quan tới tiêu đề "EML4-ALK induces cellular senescence in mortal normal human cells and promotes anchorage-independent...":
BÁO CÁO Y HỌC BONE MORPHOGENETIC PROTEIN BMP 4 AND BMP 7 REGULATE DIFFERENTIALLY TRANSFORMING GROWTH FACTOR TGF Β1 IN NORMAL HUMAN LUNG FIBROBLASTS NHLF PDF
had no direct effect on fibroblast proliferation. This is in contrast to the study of Jeffery et al. which reported inhi- bition of fibroblast proliferation but their study was per- formed on foetal fibroblasts which possess a higher intrinsic capacity for self-renewal than adult cells[r]
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BÁO CÁO Y HỌC AMPLIFICATION OF AUTOIMMUNE DISEASE BY INFECTION POTX
hybridization studies in support of productive viral infection in RA synovia [27]. Many studies have provided serological evidence of productive EBV infection in RA, and also for HHV6 and CMV [92,93]. Productive infection by EBV in the oral mucosa is signifi[r]
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BÁO CÁO Y HỌC: " HUMAN EMBRYONIC STEM CELL (HES) DERIVED DENDRITIC CELLS ARE FUNCTIONALLY NORMAL AND ARE SUSCEPTIBLE TO HIV-1 INFECTION" POT
It is known that HIV-1 can infect DCs with the virus remaining stable for long periods. DCs transmit the virus efficiently to CD4 T cells and therefore play an important role in HIV-1 infection. Our results showed that hES-DCs were susceptible to HIV-1 infection similar to that[r]
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Variant G6PD levels promote tumor cell proliferation or apoptosis via the STAT3/5 pathway in the human melanoma xenograft mouse model
Glucose-6-phosphate dehydrogenase (G6PD), elevated in tumor cells, catalyzes the first reaction in the pentose-phosphate pathway. The regulation mechanism of G6PD and pathological change in human melanoma growth remains unknown.
BÁO CÁO KHOA HỌC LINKING ENVIRONMENTAL CARCINOGEN EXPOSURE TO TP53 MUTATIONS IN HUMAN TUMOURS USING THE HUMAN TP53 KNOCK IN HUPKI MOUSE MODEL DOC
Replicative senescence and ‘crisis’ of human cells is PRIMARY 1 SENESCENT CRISIS INDUCED BY 20% O2 IMMORTALIZED CELL LINES MUTATION IN _TP53_ 2 3 MUTAGEN 5 7 11 15 19+ HUPKI Isolation of[r]
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BÁO CÁO Y HỌC INCREASED EXPRESSION OF MATRIX METALLOPROTEINASE 10 NERVE GROWTH FACTOR AND SUBSTANCE P IN THE PAINFUL DEGENERATE INTERVERTEBRAL DISC POT
These data also support the assumption that IL-1 functions both to enhance the catabolic processes involved in IVD degeneration and to enhance the processes associated with innervation and the pain response that leads to LBP and symp- tomatic IVD degeneration. Additionall[r]
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Odontogenic ameloblast-associated protein (ODAM) inhibits growth and migration of human melanoma cells and elicits PTEN elevation and inactivation of PI3K/AKT signaling
The Odontogenic Ameloblast-associated Protein (ODAM) is expressed in a wide range of normal epithelial, and neoplastic tissues, and we have posited that ODAM serves as a novel prognostic biomarker for breast cancer and melanoma. Transfection of ODAM into breast cancer cells yields suppression of cel[r]
Silvestrol induces early autophagy and apoptosis in human melanoma cells
Silvestrol is a cyclopenta[b]benzofuran that was isolated from the fruits and twigs of Aglaia foveolata, a plant indigenous to Borneo in Southeast Asia. The purpose of the current study was to determine if inhibition of protein synthesis caused by silvestrol triggers autophagy and apoptosis in cultu[r]
Exploring the information transmission properties of noise-induced dynamics: Application to glioma differentiation
Cells operate in an uncertain environment, where critical cell decisions must be enacted in the presence of biochemical noise. Information theory can measure the extent to which such noise perturbs normal cellular function, in which cells must perceive environmental cues and relay signals accurately[r]
BÁO CÁO KHOA HỌC DISCOVERY OF GSK837149A AN INHIBITOR OF HUMAN FATTY ACID SYNTHASE TARGETING THE B KETOACYL REDUCTASE REACTION POT
GSK837149A and several related analogs have been tested for cellular activity in a whole cell fatty acid synthesis assay in HepG2 cells, using [14C]acetate as a precursor, and in human p[r]
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Planar cell polarity gene expression correlates with tumor cell viability and prognostic outcome in neuroblastoma
The non-canonical Wnt/Planar cell polarity (PCP) signaling pathway is a major player in cell migration during embryonal development and has recently been implicated in tumorigenesis. Our experimental data demonstrate that high expression of Prickle1 and Vangl2 reduce the growth of neuroblastoma cell[r]
BÁO CÁO Y HỌC: " EPITHELIAL CELL SENESCENCE IMPAIRS REPAIR PROCESS AND EXACERBATES INFLAMMATION AFTER AIRWAY INJURY" DOC
P38 MAPK activation in senescent Clara cells in the airways of COPD patients The results obtained in the experiments on mice and cell cultures suggested that BrdU induces senescence of e[r]
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Comparison of oxidative stress effects on senescence patterning of human adult and perinatal tissue derived stem cells in short and long term cultures federica facchin1,2*, eva bianconi1,2*,
Human Mesenchymal Stem Cells (hMSCs) undergo senescence in lifespan. In most clinical trials, hMSCs experience long-term expansion ex vivo to increase cell number prior to transplantation, which unfortunately leads to cell senescence, hampering post-transplant outcomes.
BÁO CÁO KHOA HỌC:INVITED LECTURES DOCX
Stealth liposomes (SL), conventional liposomes surrounded by a polyethylene glycol shell, are coated with bioactive molecules. The resulting targeted stealth liposomes (TSL) bind specifically to cell surface structures. Therefore, TSL can be used as delivery systems for therapeutics and medica[r]
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HIGH YIELD FACTS IN PELVIC PAIN PPSX
L O C AT I O N O F C E RV I C A L D Y S P L A S I A : T R A N S F O R M AT I O N Z O N E
The transformation zone is the area between the old and the new squamo- columnar junctions.
The squamo-columnar junction exists between the squamous epithelium of the vagina and ectoc[r]
The transformation zone is the area between the old and the new squamo- columnar junctions.
The squamo-columnar junction exists between the squamous epithelium of the vagina and ectoc[r]
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Dietary-phytochemical mediated reversion of cancer-specific splicing inhibits Warburg effect in head and neck cancer
The deregulated alternative splicing of key glycolytic enzyme, Pyruvate Kinase muscle isoenzyme (PKM) is implicated in metabolic adaptation of cancer cells. The splicing switch from normal PKM1 to cancerspecific PKM2 isoform allows the cancer cells to meet their energy and biosynthetic demands, ther[r]
DUAL FUNCTIONS OF AP 1 IN NEURONAL CELL DEATH AND DIFFERENTIATION
64 CHAPTER 3 JNK-dependent phosphorylation of c-Jun on Ser-63 mediates NO-inducible apoptosis in human SH-Sy5y neuroblastoma cells.... 65 3.1 NO induces concentration-dependent apoptosis[r]
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BÁO CÁO KHOA HỌC: IXOCARPALACTONE A ISOLATED FROM THE MEXICAN TOMATILLO SHOWS POTENT ANTIPROLIFERATIVE AND APOPTOTIC ACTIVITY IN COLON CANCER CELLS POT
IxoA was selected for further evaluation for the fol- lowing reasons: it is found in the edible fruit of the tomatillo plant, it has previously been reported to have potent quinone reductase activity in hepatoma cells, and because it has been shown to inhibit the transfor[r]
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ISOLATION AND CHARACTERIZATION OF THREE NEW ANTI-PROLIFERATIVE SESQUITERPENES FROM POLYGONUM BARBATUM AND THEIR MECHANISM VIA APOPTOTIC PATHWAY
Cytotoxicity of these compounds was evaluated against human non-small cell lung carcinoma NCI-H460, MCF-7 breast cancer, HeLa cervical cancer and normal mouse fibro-blast cells NIH-3 T3.[r]
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IDENTIFICATION OF PADI2 AS A POTENTIAL BREAST CANCER BIOMARKER AND THERAPEUTIC TARGET
We have recently reported that the expression of peptidylarginine deiminase 2 (PADI2) is regulated by EGF in mammary cancer cells and appears to play a role in the proliferation of normal mammary epithelium; however, the role of PADI2 in the pathogenesis of human breast cancer has yet to be investig[r]