PHENETHYL ISOTHIOCYANATE UPREGULATES DEATH RECEPTORS 4 AND 5 AND INHIBITS PROLIFERATION IN HUMAN CANCER STEM-LIKE CELLS

Tumorigenicity study in mice
Animal studies were carried out in accordance with the guidelines of, and, using an approved protocol by, the Institutional Animal Care and Use Committee (IACUC), South Dakota State University (IACUC protocol ap- proval #12-087A). Twenty fem[r]

distinguish these cells from normal tissue stem cells can be identified and targeted. Oncologists eagerly await a new class of agent that may directly attack the cells that drive tumor growth. Figure 80-7 Cancer stem cells play a critical rol[r]

different MLL fusion protein variants. Specific signalsare derived from stromal cells during fetal liver anddefinitive hematopoiesis. This enables the activation ofanti-apoptotic pathways and stem cell maintenance[9,10]. Leukemic cells seem to have the ability to inter-act[r]

Ovarian cancer is a metastatic disease and one of the leading causes of gynaecology malignancy-related deaths in women. Cancer stem cells (CSCs) are key contributors of cancer metastasis and relapse.

& George, S.R. (1994) Phosphorylation and palmitoylation of thehuman D2L dopamine receptor in Sf9 cells. J. Neurochem. 63,1589–1595.41. Farrar, S.J., Whiting, P.J., Bonnert, T.P. & McKernan, R.M.(1999) Stoichiometry of a ligand-gated ion channel determined byfluor[r]

tissue engineering purposes it is often assumed that all tendon and ligament cells are similar despitetheir differing roles and biomechanics. To clarify this, we have characterised cells from varioustendons and ligaments of human and rat origin in<[r]

Lan Zhang 1,2 , He Huang 2 , Longjuan Zhang 3 , Teng Hou 2 , Shu Wu 1 , Qidan Huang 2 , Libing Song 1* and Jihong Liu 2*
Abstract
Background: Upregulator of cell proliferation 4 (URG4) has been implicated in the oncogenesis of certain cancers. However, the correlation[r]

are stained with DAPI for DNA (blue), and telomeric DNA labeled with rhodamine (red). B-lymphoid control cells (A) and Ruta 6-treated cells (B)both show no reduction in telomeric signals. Untreated control (C) and Ruta-treated (D) human brain cance[r]

against ZIP8 have a protective effect against cadmium treatment. Ourresults indicate that PKC activation negatively affects ZIP8 transporteractivity, thus protecting cells against cadmium poisoning.AbbreviationseGFP, enhanced green fluorescent protein; ERK, extracellular signal-related kinase;[r]

involved in the induction of apoptotic cell death byradiation, we examined changes in mitochondrialmembrane potential and release of pro-apoptotic mole-cules from the mitochondria in radiation-treated HeLacells. Ionizing radiation significantly disrupted themitochon[r]

Glioblastoma Multiforme (GBM) is the most common and lethal form of primary brain tumor in adults. Following standard treatment of surgery, radiation and chemotherapy, patients are expected to survive 12–14 months. Theorized cause of disease recurrence in these patients is tumor cell repopulation th[r]

Chapter 066. Stem Cell Biology (Part 2) Self-Renewal and Proliferation of Stem Cells Symmetric and Asymmetric Cell Division The most widely accepted stem cell definition is a cell with a unique capacity to produce unaltered daughter cells (sel[r]

We previously reported that IL-6 and transglutaminase 2 (TG2) were expressed in more aggressive basal-like breast cancer cells, and TG2 and IL-6 expression gave these cells stem-cell-like phenotypes, increased invasive ability, and increased metastatic potential.

tion of the disease phenotype [29]. Using similar meth-odology, another study has shown phenotypiccorrection of the clotting factor VIII disorder in ahemophilia A mouse model [30]. Hemophilia A is agenetic blood disorder characterized by mutations inI. Moreno-Gimeno et al. New advances in<[r]

tumor suppressor genes wo uld lead to prostatecarcinogenesis.Additionally, Barker et al [72] and Zhu et al [43] dis-covered crypt stem cells as the origin of intestinal can-cer. They demonstrated that Lgr5 positive or prominin1positive subpopulations were intesti nal stem[r]

tumor suppressor genes wo uld lead to prostatecarcinogenesis.Additionally, Barker et al [72] and Zhu et al [43] dis-covered crypt stem cells as the origin of intestinal can-cer. They demonstrated that Lgr5 positive or prominin1positive subpopulations were intesti nal stem[r]

4. Ousman SS, David S: Lysophosphatidylcholine induces rapid recruitmentand activation of macrophages in the adult mouse spinal cord. Glia2000, 30:92-104.5. Rosenberg GA: Matrix metalloproteinases and neuroinflammation inmultiple sclerosis. Neuroscientist 2002, 8:586-595.6. Arne[r]

tosis detection kit that determines caspase activation. DNA fragmentationwas determined using the terminal deoxynucleotidyl transferase dUTPnick-end labeling (TUNEL) assay. Flutamide and ICI 182,780 were used toinhibit androgen and estrogen receptors, respectively, and le[r]

on immunological and inflammatory processes, like a serious of other pathological and physiological responses containing of the development and progression of can- cer. NF- κ B activation is mediated frequently by plenty of chemotherapeutic agents, which generally means i[r]

Loss of Amylo-alpha-1-6-glucosidase-4-alpha-glucanotransferase (AGL) drives rapid proliferation of bladder cancer cells by upregulating Hyaluronic acid(HA) Synthase (HAS2) mediated HA synthesis. However the role of HA receptors CD44 and Hyaluronan Mediated Motility Receptor (RHAMM) in regulating the[r]