BÁO CÁO Y HỌC: "MOLECULAR BASIS OF TELAPREVIR RESISTANCE DUE TO V36 AND T54 MUTATIONS IN THE NS3-4A PROTEASE OF THE HEPATITIS C VIRUS" PDF

of steatosis exist in our patients with HCV. The first type of steatosis occurs secondary to metabolic factors namely alcohol use or the metabolic syndrome. This form of steatosis is not initiated by the hepatitis C virus however it can very well increase the progression of fibrosis ultimatel[r]

1a, 1b, 2a...).[4] Frequent HCV mutations and numerous subtypes have made the search for an HCV vaccine challenging. There is strong evidence demonstrating the association of chronic HCV infection to cirrhosis and hepatocellular carcinoma (HCC). HCV is a mounting global h[r]

of wild type BRCA1 and BRCA2, DSBs can be efficiently repaired by RAD51 mediated homologous recombination (Fig. 1B). It has been shown that BRCA1 and BRCA2 interact with RAD51, and play essential role in homologous recombination [28, 30, 31]. Thus, in the event of DNA damage associated with PARP inh[r]

1 4 1. Department of Hospital Pharmacy, School of Medicine, Kobe University, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan 2. Clinical Pathology and Immunology, Department of Biomedical Informatics, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, J[r]

4. Serfaty L, Aumaitre H, Chazouilleres O, Bonnand AM, Rosmorduc O, Poupon RE, et al. Determinants of outcome of compensated hepatitis C virus-related cirrhosis. Hepatology 1998;27:1435-1440. 5. Kasahara A, Hayashi N, Mochizuki K, Takayanagi M, Yoshioka K, Kakumu S, Iijima A<[r]

compared to those with ND. These results are consistent with a previous report among HAART-experienced subjects, thus further implicating HIV DNA in the pathogenesis of HAD. Key words: human immunodeficiency virus type 1; dementia; cognition; HIV DNA 1. INTRODUCTION Complete eradication of th[r]

recipients. Clinical Gastroenterol Hepatol. 2005; 10:S125-31 19. Lee W, Dieterich D. Challenges in the management of HIV and hepatitis C virus infection. Drugs. 2004;64(7):693-700 20. Bica I, McGovern B, Dhar R, et al. Increasing mortality due to end-stage liver disease in patients with Human[r]

4. Serfaty L, Aumaitre H, Chazouilleres O, Bonnand AM, Rosmorduc O, Poupon RE, et al. Determinants of outcome of compensated hepatitis C virus-related cirrhosis. Hepatology 1998;27:1435-1440. 5. Kasahara A, Hayashi N, Mochizuki K, Takayanagi M, Yoshioka K, Kakumu S, Iijima A<[r]

Trepo C, et al. Analysis of HCV co-infection with occult hepatitis B virus in patients undergoing IFN therapy. J Clin Virol 2005;33:150-157. 49. Villa E, Grottola A, Buttafoco P, Colantoni A, Bagni A, Ferretti I, Cremonini C, et al. High doses of alpha-interferon a[r]

the intracellular pool to the plasma membrane [5, 6]. However, sustained insulin deficiency leads to a decreased number of GLUT4 transporters, resulting in impaired responsiveness of glucose transport to both insulin and exercise [4, 7]. People with type 2 diabetes have been sho[r]

12. Stuyver L, et al. Hepatitis C virus genotyping by means of 5'-UR/core line probe assays and molecular analysis of untypeable samples. Virus Res 1995, 38: 137-57. 13. Zheng X, et al. Direct comparison of hepatitis C virus genotypes tested by INNO-LiPA HCV II and TRUGENE HCV genotypi[r]

Int. J. Med. Sci. 2006, 3 79International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2006 3(2):79-83 ©2006 Ivyspring International Publisher. All rights reserved Review Management of HCV Infection and Liver Transplantation Thomas D. Schiano, and Paul Martin Adult Liver T[r]

Int. J. Med. Sci. 2006, 3 79International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2006 3(2):79-83 ©2006 Ivyspring International Publisher. All rights reserved Review Management of HCV Infection and Liver Transplantation Thomas D. Schiano, and Paul Martin Adult Liver T[r]

Int. J. Med. Sci. 2006, 3 41International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2006 3(2):41-46 ©2006 Ivyspring International Publisher. All rights reserved Review Epidemiology of Hepatitis C Virus (HCV) Infection Theodore Sy, M. Mazen Jamal Division of Gastr[r]

improve insulin resistance and lower body fat and blood lipids are discussed and include a wide spectrum of biochemical and molecular activities that favorably affect fatty acid metabolism and cholesterol homeostasis. The biologic actions of certain constituents of soy protein, particularly c[r]

Int. J. Med. Sci. 2006, 3 63International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2006 3(2):63-68 ©2006 Ivyspring International Publisher. All rights reserved Review A Practical Approach to Managing Patients with HCV Infection Richard H. Huang, and Ke-Qin Hu Di[r]

highly significant association between the rare C allele and lower plasma HDL concentrations in female subjects. The effect remained significant after correcting for multiparametric testing according to Bonferoni and was seen only in subjects with a BMI below the median. In addition, t[r]

resistance to some antibiotics. Indeed, H. pylori strains resistant to clarithromycin and metronidazole have been increasing [11-18]. In the near future, antibiotic resistance will be the utmost impediment in the chemotherapy of H. pylori infection. In addition, new triple therapies occasionally cau[r]

FBW7, FBXW7) has recently emerged as a potent new potential tumor suppressor gene [1, 2]. The highly conserved protein consists of an NH2 terminal F-box and seven WD40 repeats in the COOH terminal region and acts as an adaptor protein providing substrate specificity for SCF (Skp–Cullin–F-box)[r]