Ostman A: Inhibition of PDGF receptor signaling in tumor stromaenhances antitumor effect of chemotherapy. Cancer Res 2002,62:5476-5484.54. Lin AM, Rini BI, Weinberg V, Fong K, Ryan CJ, Rosenberg JE, Fong L,Small EJ: A phase II trial of imatinib mesylate in p[r]
2009, accepted 8 December 2009)doi:10.1111/j.1742-4658.2009.07542.xPrevious studies have shown an anticancer effect of vitamin D, but themechanisms underlying this action have not been fully explored. Here weshow that 1,25-dihydroxyvitamin D3 (VD3, the active form of vitamin D)s[r]
receptor response, which in turn activates variousgenes for transcription in the nucleus [26]. TPD52expression at both the transcriptional and translationallevels is positively regulated by estradiol in breast can-cer cells [5] and androgens in prostate[r]
Thua thien Hue was chosen one of three biggest networks in the cancer control program in Vietnam.There is 2,641 cancer cases was registered in Thua thien Hue periode 2008, 2009; males 56.94%, females 43.06%. Thua thien Hue has a campain for the[r]
Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide. The only drug currently approved for clinical use in the treatment of advanced HCC is sorafenib. However, many patients with HCC show reduced sensitivity to sorafenib during treatment.
commonly develop dermatologic adverse drugs reactions, but rarely they are involved in systematic evaluation of their quality of life. This monocentric cross sectional study is carried out to assess quality of life in colon cancer patients experienced skin s[r]
A major impediment in the treatment of ovarian cancer is the relapse of chemotherapy-resistant tumors, which occurs in approximately 25% of patients. A better understanding of the biological mechanisms underlying chemotherapy resistance will improve treatment efficacy through genetic testing and nov[r]
does not have high specificity or sensitivity.The PSA protein has antigenic sequences that induce T-cell responses. Amongst Tlymphocytes, CD4+ T-cells are highly specific in recognition of peptide antigenspresented by major histocompatibility complexes (MHC) class II molecules a[r]
of downstream kinases (MEK and ERK1/2). 2. Activated PI3K phosphorylates the membrane lipid PIP2 to generate PIP3, which acts as a membrane-docking site for a number of cellular proteins including the serine/threonine kinases PDK1 and Akt. PDK1 has numerous cellular targe[r]
triplicate. The purified recombinant His6-tagged PR domain (> 90% purity) was directly administered into the cell cultural media with final concentrations of 1 g/mL, 2 g/mL, and 3 g/mL, respectively, after the HuH7 cells reached 80-90% confluence. Tris-HCl buffe[r]
The prognostic nutritional index (PNI), an immunity and nutrition based prognostic score, was correlated with clinical outcomes in different tumors. However, the prognostic significance of PNI has not been investigated in hormone sensitive prostate cancer (PCa).
One common screening method involves ablood test for prostate-specific antigen (PSA).Elevated levels of this antigen, normally present inlow concentrations, may indicate the presence ofprostate cancer. This test is more sensitive thanthe serum enzyme assay previously used[r]
Nanotechnology in Cancer Treatment and Detection Richard Acosta Motivation • Ineffectiveness of many Cancer treatments • Numerous side effects • Difficulties in early Cancer detection • No immunization Scale and Scope The nanoparticles discusse[r]
Although docetaxel-based chemohormonal therapy (CHT) is one of the standard treatments for castration-resistant prostate cancer (CRPC), pertinent biomarkers and precise mechanisms involved in the resistance for CHT for CRPC remain unknown.
including a decline in PSA to <0.5 or 1 ng/mL, "nonrising" PSA values, and a negative biopsy of the prostate 2 years after completion of treatment. PSA relapse is defined as three consecutive rising PSA values from the nadir value, with the<[r]
this clinical setting, the 5-FU may be functioning as a radiosensitizer. The administration of combinations of cytotoxic drugs to patients with advanced gastric carcinoma has been associated with partial responses in 30–50% of cases; responders appear to ben[r]
biopsy. Treatment of Men with Prostate Cancer and Bone Metastases 9. Q. What types of physicians and other health professionals treat patients with prostate cancer affecting the bone? A. Most often more than one health care specialist will[r]
lymphatics, causes interstitial hypertension within the tumor (which also interferes with the delivery of therapeutics to the tumor; Figs. 80-8, 80-9, and 80-10). Tumor blood vessels lack perivascular cells such as pericytes and smooth-muscle cells that normally regulate[r]
radiation fields, and individual susceptibility. Bone is among the most radioresistant organs, radiation effects being manifested mainly in children through premature fusion of the epiphyseal growth plate. By contrast, the male testis, female ovary, and bone marrow[r]