1. Introduction Although no lipids were considered to be present inside the nuclear membrane (Berg, 1951), their presence in chromatin was first demonstrated cytochemically by Chayen et al (1957) in Vicia faba root apices and liver nuclei. Sphingomyelin was further[r]
The small heterodimer partner (SHP) inhibits HBV gene expression in human hepatocyte cell lines SHP is abundant in the liver, where it performs a cru- cial function in cholesterol metabolism by modulating the transcription of enzymes i[r]
almost invisible after 60 min of exposure to 1.5 ppm of TPTC. Effects of PKC, ERK and PI3 kinase on GJIC response Organotin compounds showed that inhibition through some kinase pathways is a possible mechanism involved in the apoptotic effects [48]. [r]
The purpose of this retrospective study was to evaluate the efficacy of incorporating trans-arterial radioembolization (TARE) with systemic chemotherapy in the treatment of liver-dominant metastatic pancreatic ductal adenocarcinoma, with the aim of destroying liver metastases and improving patient o[r]
We introduce the following issues of the cytokines secretion during liver transplantation surgery in this review article; 1) the aspect of cytokines secretion during liver transplantation surgery, 2) the evidences of association of cytokines concentration with post-transplantation graft survival,...
2 patients were B and 104 patients were A in this study. The tumor stage was determined according to 2002 AJCC/UICC tumor-node-metastasis (TNM) classification system and the Barcelona-Clinic Liver Cancer (BCLC) sta- ging classification. Follow-up was as described in
1 Department of Medical Biochemistry and Biology, University of Bari, Italy; 2 Department of Zoology, Laboratory of Histology and Comparative Anatomy, University of Bari, Italy; 3 Center for the Study of Mitochondria and Energy Metabolism (CNR) Bari[r]
Emerging evidence indicates that inappropriate cell-cell fusion might contribute to cancer progression. Similarly, mesenchymal stem cells (MSCs) can also fuse with other cells spontaneously and capable of adopting the phenotype of other cells. The aim of our study was to investigate the role of MSCs[r]
Hepatocellular carcinoma (HCC) is a liver malignancy and a major cause of cancer mortality worldwide. AURKA (aurora kinase A) is a mitotic serine/threonine kinase that functions as an oncogene and plays a critical role in hepatocarcinogenesis.
We also detected the function of ZD55-AChE in the pancreatic cancer cell line BxPc-3, liver cancer cell line Huh-7 and SMMC-7721, and colon cancer cell line SW480 and HCT116, and found t[r]
TRANG 8 VII LIST OF TABLES TRANG 9 VIII LIST OF FIGURES Figure 1.1 Events that occur during liver fibrosis 3 Figure 1.2 Paracrine factors and cell types involved in the activation 4 of H[r]
This study shows that microRNA-320 (miR-320) is associated with many important cell functions, including cell differentiation, proliferation, migration, and apoptosis. However, the role of miR-320 in vascular smooth muscle cells (VSMCs) and proliferative vascular diseases is still completely unclear[r]
Overexpression of FHL1C induces apoptosis of T-ALL cells To examine the role of FHL1C in T-ALL, we transiently overexpressed FHL1C in Jurkat cells, a human T-ALL cell line bearing Notch1[r]
Approximately one third of all patients with CRC present with, or subsequently develop, colorectal liver metastases (CRLM). The objective of this population-based analysis was to assess the impact of resection of liver only, lung only and liver and lung metastases on survival in patients with metast[r]
Changes in concentration and distribution of Kupffer cells in tumor and liver tissues following laser ablation of tumors In a previous study we have shown that Kupffer cell numbers significantly reduced at site of the tumor abla[r]
Results dT-QX exhibits varied cytotoxicity on liver cancer cells that have different levels of TK1 and TYMP In addition to the reported selective activity of dT-QX [29], significant vari[r]
transformed cells, and are alternatively and/or coordi- nately expressed in several cancers, raising the possibility that a feedback loop might exist in this network [40-44]. It is well established that activation of the STAT3 sig- naling pathway promote[r]
While the CLIP score has been validated in patients with a wide range of HCC tumor burden who undergo a variety of locoregional therapies (including no ther- apy), it has several critical limitations. Like the Okuda system, it considers a wide range of ear[r]
This study explored the effect of liver resection on perioperative circulating tumor cells (CTCs) and found that the prognostic significance of surgery was associated with changes in CTC counts in patients with hepatocellular carcinoma (HCC).
The latent period between the introduction of ticlopi- dine and the appearance of hepatotoxicity is variable, ranging from one week to six months, but it is in the range of two to 12 weeks in most patients [5]. Hepatic toxicity is not[r]