BÁO CÁO Y HỌC: "TRANSLATIONAL CONTROL PLAYS A PROMINENT ROLE IN THE HEPATOCYTIC DIFFERENTIATION OF HEPARG LIVER PROGENITOR CELLS" DOCX

relatively similar pattern to that found in the untreated control cells. The pairwise comparison analysis demonstrated four significantly up-regulated (COBRA1, ITGB4, STAU2, and HMGN3) genes and one down-regulated (ANK3) gene. All these genes exert their function on transcriptional and translational[r]

PPARγ, and PPARδ. While PPARα is mainly expressed in liver, muscle, kidney and heart, PPARγ is most abundant in adipocytes, intestinal cells and macrophages and PPARδ is expressed in many tissues [2-4]. Each subgroup is activated by a certain variety of fatty acids and their derivatives and b[r]

and persisted for more than 24 hr. This information provided a novel insight into the mechanisms of action of ethanol (1mM) in human hepatocellular carcinoma cells. Key words: Ethanol, HepG2 cells, protein kinases, signal transduction, transcription factors, gene expression 1. Introduction Ap[r]

FBW7, FBXW7) has recently emerged as a potent new potential tumor suppressor gene [1, 2]. The highly conserved protein consists of an NH2 terminal F-box and seven WD40 repeats in the COOH terminal region and acts as an adaptor protein providing substrate specificity for SCF (Skp–Cullin–F-box)[r]

change in muscle strength (r=0.73, P=0.001). Group assignment was be the only independent predictor of hSGLT3 transcript levels, explaining 68% of its variability (P=0.01). Our data show that hSGLT3, but not GLTU4, expression was enhanced in skeletal muscle after 16 weeks of resistance training. Thi[r]

sity and is influenced by genetic and environmental factors, and in particular, changes in diet and physical activity [8,9]. Lipid abnormalities associated with obe-sity include increased overall production of lipids with elevated concentrations of fatty acids, triacyl-glycerols, and low-density lip[r]

the MTT assay. The results showed that hESC survivability after exposure to 25oC and 4oC for 24h was 77.3 ± 4.8 % and 64.4 ± 4.4 % respectively (significantly different, P < 0.05). The corresponding survival rates after 48h exposure to 25oC and 4oC was 71.0 ± 0.5 % and 69.0 ± 2.3 % respective[r]

C. Persistence of hepatitis B and hepatitis C viral genomes in primary liver cancers from HBsAg-negative patients: a study of a low-endemic area. Hepatology 1993;17:20-29. 33. Koike K, Kobayashi M, Gondo M, Hayashi I, Osuga T, Takada S. Hepatitis B virus DNA is frequently found in live[r]

4. Serfaty L, Aumaitre H, Chazouilleres O, Bonnand AM, Rosmorduc O, Poupon RE, et al. Determinants of outcome of compensated hepatitis C virus-related cirrhosis. Hepatology 1998;27:1435-1440. 5. Kasahara A, Hayashi N, Mochizuki K, Takayanagi M, Yoshioka K, Kakumu S, Iijima A, Urushihar[r]

which is the final irreversible stage characterized by parenchymal nodules with encircling fibrous septa. The hepatitis C virus is not considered to directly injure the liver but it rather triggers an HCV-specific lymphoproliferation. Through profuse cytokine production and also a direct cyto[r]

of wild type BRCA1 and BRCA2, DSBs can be efficiently repaired by RAD51 mediated homologous recombination (Fig. 1B). It has been shown that BRCA1 and BRCA2 interact with RAD51, and play essential role in homologous recombination [28, 30, 31]. Thus, in the event of DNA damage associated with PARP inh[r]

4. Serfaty L, Aumaitre H, Chazouilleres O, Bonnand AM, Rosmorduc O, Poupon RE, et al. Determinants of outcome of compensated hepatitis C virus-related cirrhosis. Hepatology 1998;27:1435-1440. 5. Kasahara A, Hayashi N, Mochizuki K, Takayanagi M, Yoshioka K, Kakumu S, Iijima A, Urushihar[r]

African Americans which may explain a low SVR in this population compared to other groups [13]. African American patients showed significantly lower decrease in HCV RNA over the first 24 hours than Caucasians and significantly longer delay in initial response and significant difference in the[r]

is the second most common cause of death from cancer [1]. Helicobacter pylori (H. pylori) strains carrying the cytotoxin-associated gene A (cagA) gene are strongly associated with increased risk of gastric adenocarcinoma [2]. However, only some of those infected developed H. pylori-related di[r]

16. Regelson W, Loria R, Kalimi M. Hormonal intervention: "buffer hormones" or "state dependency". The role of dehydroepian-drosterone (DHEA), thyroid hormone, estrogen and hypophy-sectomy in aging. Ann N Y Acad Sci. 1988; 521: 260-73. 17. Herbert J. Neurosteroids, brain damage, and mental illness.[r]

Int. J. Med. Sci. 2006, 3 63International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2006 3(2):63-68 ©2006 Ivyspring International Publisher. All rights reserved Review A Practical Approach to Managing Patients with HCV Infection Richard H. Huang, and Ke-Qin Hu Division of Gast[r]

183/pTyr185) rabbit antibody was added, and in-cubated for 1 hour. After washing the wells, an anti-rabbit IgG-HRP antibody was added, and incu-bated for 30 minutes. Stabilized Chromogen (TMB) was added to each well, and from the absorbance at 450 nm, the phosphorylated JNK 1&2 protein level[r]

acute HCV infection persists and 4% to 20% of patients with chronic hepatitis C will develop liver cirrhosis within 20 years. In patients with liver cirrhosis, the risk to develop HCC is 1-5% per year. Current standard therapy is the combination of pegylated interferon-α (PEG-IFN-α) and ribavirin. D[r]

1a, 1b, 2a...).[4] Frequent HCV mutations and numerous subtypes have made the search for an HCV vaccine challenging. There is strong evidence demonstrating the association of chronic HCV infection to cirrhosis and hepatocellular carcinoma (HCC). HCV is a mounting global health c[r]

margins is of paramount importance and that histological factors have an inconsistent influence on biologic behavior [3]. Sarcomatous stromal elements, including angiosarcoma, chondrosarcoma, leiomyosarcoma, osteosarcoma, and rhabdomyosarcoma, are rarely encountered in malignant phyllodes tumors [4][r]