MESENCHYMAL STEM CELLS FOR THE TREATMENT OF CANCER

Mesenchymal stem cells (MSCs) are possibly the most potent type of stem cells for the treatment of many diseases since they possess many advantageous properties, such as abundant source, ease of isolation, and potential to differentiate and trans-differentiate into different types of cells.

able to change the size of the stem cell pool have little effect on more mature blood cells.
For example, the growth factor erythropoietin, which stimulates red blood cell production from more mature precursor ce[r]

Xem Thêm " CHAPTER 068. HEMATOPOIETIC STEM CELLS (PART 1) DOCX "

Xem Thêm " CHAPTER 068 HEMATOPOIETIC STEM CELLS PART 2 "

unknown mechanism. This is particularly important as ovarian cancer patients who do not receive treatment for a short period (6 – 22 months) while in remission after surgery and first line of chemotherapy [4]. During this time it is hypothesized that the residual tumor[r]

Elucidating the precise properties of cancer stem cells (CSCs) is indispensable for the development of effective therapies against tumors, because CSCs are key drivers of tumor development, metastasis and relapse.

The development of molecular targeted therapies may lead to the rational selection of treatment for adenocar- cinoma patients based on specific molecular mecha- nisms whose deregulated activity contributes to the initiation, development, and metastati[r]

Tumor recurrence and metastasis are the most common reason for treatment failure. Metastasis-associate in colon cancer-1 (MACC1) has been identified as a metastatic and prognostic biomarker for colorectal cancer and other solid tumors. Aldehyde dehydrogenase 1 (ALDH1), a marker of cancer stem cells,[r]

Cancer stem cells has been widely investigated due to its essential role in cancer progression and drug resistance. Here, we try to find a new therapeutic target for cervical cancer stem cells.

A subpopulation of tumor cells with distinct stem-like properties (cancer stem-like cells, CSCs) may be responsible for tumor initiation, invasive growth, and possibly dissemination to distant organ sites.

Cancer stem cells (CSC) are believed to play a crucial role in cancer recurrence due to their resistance to conventional chemotherapy and capacity for self-renewal. Recent studies have reported that salinomycin, a livestock antibiotic, selectively targets breast cancer stem cells 100-fold more effec[r]

Mesenchymal stem cells (MSCs) have been investigated as a new treatment option for various diseases in recent years. However, the role of placenta-derived MSCs in children with asthma remains unclear.

Scleroderma is an autoimmune disease manifested by painful digital ulcers, joint contracture and skin thickening. Bone marrow-derived mesenchymal stem cells (BMMSCs) have become a recent focus of interest in tissue regeneration. The aim of this work was to study the changes of elastic fibers in loca[r]

Distraction osteogenesis (DO) is a widely used self-tissue engineering. However, complications and discomfort due to the long treatment period are still the bottleneck of DO. Novel strategies to accelerate bone formation in DO are still needed. P38 is capable of regulating the osteogenic differentia[r]

Mesenchymal stem cells are multipotent non-hematopoietic progenitor cells that show the potential in treatment for autoimmune diseases because of their ability to differentiate along different lineages in addition to the low[r]

Ovarian cancer is a metastatic disease and one of the leading causes of gynaecology malignancy-related deaths in women. Cancer stem cells (CSCs) are key contributors of cancer metastasis and relapse.

Chemoresistance of glioblastoma multiforme (GBM) has been attributed to the presence within the tumor of cancer stem cells (GSCs). The standard therapy for GBM consists of surgery followed by radiotherapy and the chemotherapeutic agent temozolomide (TMZ).

Reported studies on colorectal cancer tissue display amplifications at chromosome 8q, 13 and 20q, and dele- tions at chromosome 8p, 17p and 18q [15 – 17]. Amplifi- cations at chromosome 13 and 20 were detected in 11 of our 20 patients at tumour tissue analyses while such al- terations[r]

Genistein has been known to inhibit proliferation and induce apoptosis in several kinds of cancer cells. While knowledge of genistein in regulating epithelial mesenchymal transition (EMT) of colon cancer cells is unknown.

Roles of cancer stem cells and early growth response gene 1 (Egr1) in carcinogenesis have been extensively studied in lung cancer. However, the role of Egr1 in the metastasis of lung cancer remains undetermined, especially in regard to stem cell-related pathways.

Reactive oxygen species (ROS) are produced as by-products of several intracellular metabolic pathways and are reduced to more stable molecules by several protective pathways. The presence of high levels of ROS can be associated with disturbance of cell function and could lead to apoptosis. The prese[r]

Epithelial-to-mesenchymal transition (EMT) and cancer stem cells (CSC) contribute to tumour progression and metastasis. Assessment of transcription factors involved in these two mechanisms can help to identify new targets for an oncological therapy. In this study, we focused on the evaluation of the[r]