CLINICAL TRIALS IN NEUROLOGY

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TÀI LIỆU CLINICAL TRIALS IN GYNECOLOGICAL CANCER PPT

REVIEW PAPERClinical trials in gynecological cancerE.L. TRIMBLE, J. DAVIS, P. DISAIA, K. FUJIWARA, D. GAFFNEY, G. KRISTENSEN,J. LEDERMANN, J. PFISTERER, M. QUINN, N. REED, M. SCHOENFELDT & J.T. THIGPEN(ON BEHALF OF THE GYNECOLOGIC CANCER INTERGROUP)National Cancer Institute—Can[r]

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CANNABINOIDS: POTENTIAL ANTICANCER AGENTS PDF

(Cesamet) are approved for this purpose.•Other potential palliative effects of cannabinoids in cancer patients — supported byPhase III clinical trials — include appetite stimulation and pain inhibition. In relationto the former,dronabinol is now prescribed for anorexia as[r]

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CHAPTER 081. PRINCIPLES OF CANCER TREATMENT (PART 19) PPTX

Chapter 081. Principles of Cancer Treatment (Part 19) Solid Tumors Small-molecule epidermal growth factor (EGF) antagonists act at the ATP binding site of the EGF receptor tyrosine kinase. In early clinical trials, gefitinib showed evidence of responses in a small fracti[r]

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CHAPTER 088. HEPATOCELLULAR CARCINOMA (PART 8) DOCX

Chapter 088. Hepatocellular Carcinoma (Part 8) Table 88-5 Some Randomized Clinical Trials Involving Transhepatic Artery Chemoembolization (TACE) for Hepatocellular Carcinoma Author Year Agents 1 Agents 2 Survival Effect Kawaii 1992 Doxorubicin + embo Embo No Chang 1994 Cisplatin + emb[r]

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CHAPTER 065. GENE THERAPY IN CLINICAL MEDICINE (PART 3) DOCX

Chapter 065. Gene Therapy in Clinical Medicine (Part 3) Long-Term Expression in Genetic Disease: In Vivo Gene Transfer with Recombinant Adeno-Associated Viral (AAV) Vectors Recombinant AAV vectors have emerged as attractive gene delivery vehicles for genetic disease. Eng[r]

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KHÁNG SINH VÀ SỰ ĐỀ KHÁNG KS

1Pham Hong Nhung• Trình bày ñược khái niệm về kháng sinh.• Trình bày ñược cơ chế tác ñộng của kháng sinh lêntế bào vi khuẩn.• Trình bày ñược khái niệm ñề kháng kháng sinh.• Trình bày ñược các cơ chế ñề kháng kháng sinh củavi khuẩn và cơ chế lan truyền gene ñề kháng khángsinh.Mục tiêu học tập2• Kháng[r]

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8THE USE OF HYPOTHESISTESTINGSTATISTICS IN CLINICAL TRIALS

Chapter8The use of hypothesis-testingstatistics in clinical trialsIt has been rightly observed that while it does not take a great mind to make simplethings complicated, it takes a very great mind to make complicated things simple.Austin Bradford Hill (Hill, 1962; p. 8)How to design

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CHAPTER 123 CLOSTRIDIUM DIFFICILE–ASSOCIATED DISEASE INCLUDING PSEUDOMEMBRANOUS COLITIS PART 4

bid x 10 da 89 22 Fusidic acid 500 mg tid x 10 d 93 28 Bacitracin 25,000 U qid x 10 d 80 42 aData from randomized trials reported in 2006.

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KHÁNG SINH

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CHAPTER 080. CANCER CELL BIOLOGY AND ANGIOGENESIS (PART 11) PPS

identification of several low-molecular-weight compounds that bind to the hydrophobic pockets of either Bcl-2 or Bcl-XL and block their ability to associate with death-inducing BH3-only proteins. These compounds inhibit the antiapoptotic activities of Bcl-2 and Bcl-XL at nanomolar concentrations and[r]

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KHÁNG SINH

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KHÁNG SINH

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HEPATOCELLULAR CARCINOMA: TARGETED THERAPY AND MULTIDISCIPLINARY P40 PPSX

sensitivity to the individual components of a treatment regimen once progressionoccurs, which may aid in reserving drugs for which there remains sensitivity for fur-ther use. Unlike the mutational mechanisms that underlie resistance with systemicchemotherapies, resistance to targeted agents p[r]

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TÀI LIỆU NEURAL PLASTICITY IN ADULT SOMATIC SENSORY-MOTOR SYSTEMS PPTX

regulation of sensory transmission than trimming a subset of whiskers presumablybecause restricted deprivation creates competition between active and inactive inter-connected cell groups. Activity-based changes in function can be induced by alteredtactile experience throughout life, but early[r]

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GALE ENCYCLOPEDIA OF AMERICAN LAW 3RD EDITION VOLUME 4 P50 POTX

years of the AIDS (acquired immune deficiencysyndrome) epidemic led to the creation of a newFDA category, treatment investigational new drug(treatment IND), that established new proceduresfor more rapid and flexib le drug approval.The pharmaceutical company Burroughs We ll-come first presented AZT a[r]

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CHAPTER 080. CANCER CELL BIOLOGY AND ANGIOGENESIS (PART 6) POTX

HER2/neu is a target in human breast cancer. The gene encoding HER2/neu, a member of the EGFR family, is amplified in ~20% of breast cancers. Tumors that overexpress HER2/neu are less responsive to chemotherapy, and patients with these tumors have a reduced survival compared with patie[r]

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BÁO CÁO HÓA HỌC:" BIOMARKERS IN T CELL THERAPY CLINICAL TRIALS" DOCX

Gupta S, Wistuba II: Decitabine effect on tumor global DNA methylationand other parameters in a phase I trial in refractory solid tumors andlymphomas. Clin Cancer Res 2009, 15(11):3881-3888.46. Melenhorst JJ, Scheinberg P, Chattopadhyay PK, Gostick E, Ladell K,Roederer M, Hensel NF, Do[r]

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CHAPTER 081 PRINCIPLES OF CANCER TREATMENT PART 9

are those that result in the patient's death. Development of targeted agents should proceed quite differently. While Phase I–III trials are still conducted, molecular analysis of human tumors more precisely defines targets expressed in a patient's tumor and should allow patient[r]

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BÁO CÁO HÓA HỌC: " QUALITY OF LIFE DATA AS PROGNOSTIC INDICATORS OF SURVIVAL IN CANCER PATIENTS: AN OVERVIEW OF THE LITERATURE FROM 1982 TO 2008" POT

colorectal cancer, head and neck cancer, melanoma and other cancers. With few exceptions, thefindings showed that quality of life data or some aspects of quality of life measures were significantindependent predictors of survival duration. Global quality of life, functioning domains andsymptom score[r]

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TÀI LIỆU PSYCHOTHERAPY AND SURVIVAL IN CANCER: THE CONFLICT BETWEEN HOPE AND EVIDENCE PPTX

and the definite confounding of psychosocial treatment with en-hanced medical monitoring and care in J. L. Richardson et al.(1990), McCorkle et al. (2000), and Kuchler et al. (1999).Would another rating scale have been more helpful? Over adecade ago, Moher et al. (1995) identified 25 differen[r]

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CLINICAL TRIALS IN NEUROLOGY

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