ASPIRIN AND NSAIDS IN THE PREVENTION OF CANCER ALZHEIMER S DISEASE AND OTHER NOVEL THERAPEUTIC ACTIO...

Poor prognosis in gallbladder cancer is due to late presentation of the disease, lack of reliable biomarkers for early diagnosis and limited targeted therapies. Early diagnostic markers and novel therapeutic targets can significantly improve clinical management of gallbladder cancer.

Metastasis of colorectal cancer (CRC) is directly linked to patient survival. We previously identified the novel gene Metastasis Associated in Colon Cancer 1 (MACC1) in CRC and demonstrated its importance as metastasis inducer and prognostic biomarker.

Cell-free DNA’s (cfDNA) use as a biomarker in cancer is challenging due to genetic heterogeneity of malignancies and rarity of tumor-derived molecules. Here we describe and demonstrate a novel machine-learning guided panel design strategy for improving the detection of tumor variants in cfDNA.

Cancer is a defiant disease which cure is still far from being attained besides the colossal efforts and financial means deployed towards that end. The continuing setbacks encountered with today’s arsenal of anti cancer drugs and cancer therapy modalities; show the need for a radical approach in ord[r]

Colorectal cancer is the third most common malignancy in humans and novel therapeutic approaches are urgently needed. Autophagy is an evolutionarily highly conserved cellular process by which cells collect unnecessary organelles or misfolded proteins and subsequently degrade them in vesicular struct[r]

such infected rice and wheat straw with Fusarium Fungus fed to these animals causes severe health problem, of these most common disease occurred among them is Deg Nala disease. This disease is characterized by general malaise, edema o[r]

Colorectal cancer is one of the major causes of cancer mortality world-wide. Prevention would improve if at-risk subjects could be identified. The aim of this study was to characterise plasma protein biomarkers associated with the risk of colorectal cancer in samples collected prospectively, before[r]

Pancreatic adenocarcinoma is one of the most lethal cancers, yet it remains understudied and poorly understood. Hyperinsulinemia has been reported to be a risk factor of pancreatic cancer, and the rapid rise of hyperinsulinemia associated with obesity and type 2 diabetes foreshadows a rise in cancer[r]

Novel therapeutic approaches are required to treat ovarian cancer and dependency on glycolysis may provide new targets for treatment.

Anemia is a major cause of morbidity in patients with cancer resulting in poor physical performance, prognosis and therapy outcome. The aim of this study is to assess the efficacy of intravenous (iv) iron administration for the correction of anemia, for the prevention of exacerbation of anemia, for[r]

Esophageal adenocarcinoma (EAC) incidence is increasing rapidly. Esophageal cancer has the second lowest 5-year survival rate of people diagnosed with cancer in Canada. Given the poor survival and the potential for further increases in incidence, phase-specific cost estimates constitute an important[r]

Kiss-1 and Kiss-1R have been suggested as a novel pair of metastasis suppressors for several human solid tumours, however, their role in colorectal cancer remains largely unknown. Therefore, the aim of this study was to investigate the role and signal transduction of Kiss-1 and Kiss-1R in colorectal[r]

The present study was concluded to document the hematological evaluation of three different treatment regimens in clinical cases of diaphragmatic hernia in buffaloes which were brought to TVCC, LUVAS Hisar during the research period. Three different NSAIDs were tried and categorized in three groups[r]

In this paper, we have reviewed some novel insights in the area of fertility enhancement by considering certain strategies. Further, this article also describes the various management, nutritional, prophylactic, therapeutic and breeding aspects to increase reproductive efficiency in farm animals.

To investigate the alterations in plasma concentration of dopamine in patients with Parkinson’s disease. Subjects and methods: Changes in plasma concentration of dopamine were analyzed to find its correlations and clinical features in 45 patients with Parkinson’s disease (PD group) and 40 healthy pe[r]

was born 30 November 1835 and raised in Hannibal, Missouri. There he absorbed many of the influences that would inform his most lasting contributions to American literature. During his youth,he delighted in the rowdy play of boys on the riveran[r]

To evaluate the screening results for pre-eclampsia - eclampsia by mean artery blood pressure, PAPP-A and uterine artery doppler at 11 weeks 0 day to 13 weeks 6 days of gestation. The efficacy of low-dose aspirin prophylaxis in prevention of preeclampsia in high-risk pregnancy.

About 20% of patients with primary breast cancer develop metastatic disease during the course of the disease. At this point the disease is considered incurable and thus treatment is aimed at palliation and life prolongation. As many patients will have received both an anthracycline and a taxane in t[r]

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to inhibit several pathways in experimental models of breast carcinogenesis, but epidemiological evidence remains insufficient to support their use for breast cancer prevention. We examined the association between use of NSAIDs and breast[r]

Ovarian cancer is a metastatic disease and one of the leading causes of gynaecology malignancy-related deaths in women. Cancer stem cells (CSCs) are key contributors of cancer metastasis and relapse.