Atomic force microscopic imaging of seeded fibril for-mation and fibril branching by the Alzheimer’s diseaseamyloid-b protein. Chem Biol 4, 951–959.14 Soto C, Castano EM, Kumar RA, Beavis RC &Frangione B (1995) Fibrillogenesis of synthetic amyloid-b peptides is dependent o[r]
whereby osteoarthritis resulted in neuroinflammation as well as exacerbation and acceleration of AD pathology.Results: Induction of osteoarthritis exacerbated and accelerated the development of neuroinflammation, asassessed by glial cell activation and quantification of inflamma[r]
easy labeling of diffuse plaques in the Alzheimer brains by a newmethenamine silver stain. Acta Neuropathol (Berl) 1990, 79:569-72.15. Braak H, Braak E: Neuropathological stageing of Alzheimer-relatedchanges. Acta Neuropathol (Berl) 1991, 82:239-259.16. Vitek MP, Brown CM, Colton CA: A[r]
Tanzi R, Jones K, Hyman BT, Albert MS. 2000. Use of structuralmagnetic resonance imaging to predict who will get Alzheimer’sdisease [see comments]. Ann Neurol 47(4):430–9.[34] Kleinbaum DG, KLL, MKE. 1988. Applied Regression Analysis andOther Multivariable Methods, p. 601–31, second edition e[r]
experiments. HH, TL and SH measured the neuropathological lesions. SG andPJK collected the autopsy series. MP, MH, HH and PJK provided commentsand discussions on the progress of the manuscript. All authors have readand approved the final version.Competing interestsThe authors declare t[r]
2006). The active form of IL-18 induces signal transduction by binding to itsreceptor, IL-18α/β receptor (IL1Rrp/IL1RAPL) expressed by diverse cell types,including neurons and glia cells. In adult brains of untreated BALB/c mice, IL-18 isconstitutively the most highly expressed cytokine (Fig.[r]
vices), but African Americans expressed a greater degree of need in comparison to white caregivers in all service categories except medical services.38 Roberts et al. (2003) found that African Ameri-cans, when compared to whites, reported lower use of a range of information sources about dementia (e[r]
van Duijn C, Visser P, Petersen RC. Mild cognitive impairment: beyondcontroversies, towards a consensus. J Intern Med 2004; 256: 240-246.12. Portet F, Ousset PJ, Visser PJ, Frisoni GB, Nobili F, Scheltens P, Vellas B, TouchonJ; MCI working group of the European Consortium on Alzheimer's
Non-hydrolytic functions of T-AChE peptides S. A. Greenfield et al.606 FEBS Journal 275 (2008) 604–611 ª 2008 The Authors Journal compilation ª 2008 FEBST30 within its C-terminus (Fig. 1A). However, preli-minary data from our laboratory suggest that glialcells will express a7-nAChR in response[r]
Modulation of a-synuclein aggregation by dopamine in thepresence of MPTP and its metabolitePrashant N. Jethva, Jay R. Kardani and Ipsita RoyDepartment of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, IndiaIntroduc[r]
then demonstrate how crosses of TGF-β1 mutant mice with mouse models of Alzheimer's disease(AD) produced important new information on the role of inflammation in AD and on theexpression of different neuropathological phenotypes that characterize this disease.Inflam[r]
Markesbery WR, Ehmann WD (1994) Trace element alterations in Alzheimer’s disease. In: TerryRD, Katzman R (eds) Alzheimer’s disease. Raven Press, New York, NYMarkesbery WR, Schmitt FA, Kryscio RJ, Davis DG, Smith CD, Wekstein DR (2006)Neuropathologic substrat[r]
suggests that prefibrillar soluble Ab oligomers induce AD-related synapticdysfunction. The size of Ab oligomers is distributed over a wide molecularweight range (from < 10 kDa to > 100 kDa), with structural polymor-phism in Ab oligomers of similar sizes. Recent studies have demonstrated[r]
cursor to amyloidosis: a discussion of the occurrence, role, andimplications. In Molecular Chaperones in the Cell (Lund, P., ed.),Frontiers in Molecular Biology Series, pp. 257–278. OxfordUniversity Press, Oxford.63. Carrel, R.W. & Gooptu, B. (1998) Conformational changes anddisease – serpin[r]
M, Mathews PM, Jucker M: Cerebral hemorrhage after passiveanti-Abeta immunotherapy. Science 2002, 298:1379.89. Nicoll JA, Wilkinson D, Holmes C, Steart P, Markham H, Weller RO:Neuropathology of human Alzheimer disease after immuni-zation with amyloid-beta peptide: a case report. Nat Me[r]
Save Your Brain52 We prefer daily routines with predictable outcomes and develop schedules with predictable expectations and behav-ioral outcomes. Structure and organization is, admittedly, very important, as chaos can break down a person, family, and even a government. A[r]
Difference between present perfect and present perfectcontinuous tensesThe present perfect continuous tense is used to talk about a continuous, but not necessarily finished action orsituation.The present perfect tense is used to talk about a finished action or situation.Compare:[r]
Position of adverbs: difference between British and AmericanEnglishMid-position adverbs usually go after auxiliary verbs, after am / are / is / was / were and before other verbs.She has never written to me.The discussion was mainly about politics.When there are two or mor[r]