TESTICULAR GERM CELLS TUMOURS

A select number of relatively rare metastatic malignancies comprising trophoblast tumours, the rare childhood cancers, germ cells tumours, leukemias and lymphomas have been routinely curable with chemotherapy for more than 30 years. However for the more common metastatic malignancies chemotherapy tr[r]

Germ cell neoplasia in situ (GCNIS), is preinvasive stage of testicular germ cell tumours (TGCTs). Fibrillins, which are integral components of microfibrils are suggested to be involved in cancer pathogenesis and maintenance of embryonic stem cells pluripotency. The aim of this study was to examine[r]

Glioma is a common malignant tumours in the central nervous system (CNS), that exhibits high morbidity, a low cure rate, and a high recurrence rate. Currently, immune cells are increasingly known to play roles in the suppression of tumourigenesis, progression and tumour growth in many tumours.

genetically distinct haploid gametes. Initiation and regulation of mammalian meiosis dif- fers between the sexes. In females, meiosis is initiated during embryo development and arrested shortly after birth during prophase I. In males, spermatogonial stem cells ini- tiate meiosis at puberty an[r]

Testicular germ cell tumours (TGCTs) are characterised by an overall high cisplatin-sensitivity which has been linked to their continued expression of pluripotency factors.

We designed dsRNA targeting the oystervasa-like gene Oyvlg, specifically expressed in oyster germ cells.In vivoinjection of oyvl-dsRNA into the gonad provokes a knockdown phenotype corres[r]

Quá trình hình thành noãn gồm 7 bước: sinh tế bào mầm nguyên thủy PGC – primordial germ cells; di chuyển PGC tới tuyến sinh dục; định vị PGC trong tuyến sinh dục; biệt hóa PGC thành noãn[r]

_• Tumours can be benign not cancer or malignant cancer _ _• Metastatic cancer occurs when cancerous cells spread into other _ surrounding tissues, or enter the circulatory system and tr[r]

Testicular cancer and reproduction are sensitive topics. Recruiting the controls through hospital settings aims to facilitate the recruitment of our young male population, as well as managing biological sampling. To ensure that both cases and controls are recruited at a regional level, we dec[r]

This is not entirely surprising in light of the fact that ERα is not present within the seminiferous epithe-lium [109,110] and although ERβ is found in Sertoli cells and nearly all germ [r]

Synchronous multifocal tumours are commonly observed in urothelial carcinomas of the bladder. The origin of these physically independent tumours has been proposed to occur by either intraluminal migration (clonal) or spontaneous transformation of multiple cells by carcinogens (field effect). It is u[r]

The human COL11A1 gene has been shown to be up-regulated in stromal cells of colorectal tumours, but, so far, the immunodetection of procollagen 11A1, the primary protein product of COL11A1, has not been studied in detail in human colon adenocarcinomas.

Hypericum japonicum Thunb. ex Murray is widely used as an herbal medicine for the treatment of hepatitis and tumours in China. However, the molecular mechanisms of its effects are unclear. Our previous research showed that extracts of H. japonicum can induce apoptosis in leukaemia cells.

Little is known about the role of glial host cells in brain tumours. However, supporting stromal cells have been shown to foster tumour growth in other cancers. This cell population was subsequently characterised using gene expression analyses and immunocytochemistry. Furthermore, sphere formation w[r]

A large number of algorithms is being developed to reconstruct evolutionary models of individual tumours from genome sequencing data. Most methods can analyze multiple samples collected either through bulk multi-region sequencing experiments or the sequencing of individual cancer cells. However, rar[r]

Although a higher concentration in the medium is toxic and affects cell survival, H2O2, even at physio-logical concentrations 30–50lm, was shown to induce apoptosis in testicular Leydig [r]

radiation as well as surgery. Assessment of this risk status has been largely dependent on histopathological variables, with vascular invasion being the most consistent prognos- tic tool for predicting disease relapse [ 22 ]. However, dis- agreements in scoring vascular invasion exist, more evident[r]

Testicular germ cell cancer (TGCC) develops from pre-malignant germ neoplasia in situ (GCNIS) cells. GCNIS originates from fetal gonocytes (POU5F1+ /MAGE-A4− ), which fail to differentiate to pre-spermatogonia (POU5F1− /MAGE-A4+ ) and undergo malignant transformation.

The aetiology of testicular cancer remains elusive. In this manuscript, we review the evidence regarding the association between cannabis use and testicular cancer development. Methods: In this systematic review and meta-analysis, we reviewed literature published between 1st January 1980 and 13th Ma[r]

Prognostic value of immune cells is not clear in testicular germ cell tumors (TGCTs). We aimed to investigate the prognostic value of tumor-infiltrating neutrophils in TGCTs. Increased CD66b + TIN was significantly associated with presence of metastasis, S stage, and nonseminomatous germ cell tumor[r]