DEVELOPMENT OF ROSUVASTATIN FLEXIBLE LIPIDBASED NANOPARTICLES: PROMISING NANOCARRIERS FOR IMPROVING INTESTINAL CELLS CYTOTOXICITY

in the current experimental system are acting as nonspe- cific target molecules. Future experimental steps include wrapping the surface of GNPs with a targeting agent to selectively deliver GNPs to malignant cells followed by generation of hyperthermia using non-invasive RF. In[r]

Potential mechanisms underlying HXA 3
release
Identification of a factor such as HXA 3 , which is responsible for the transmigration of neutrophils across the mucosal barrier for entry into the intestinal lumen, has addressed an important question of epit[r]

Increased affinity for lipid by LNCaP cells in plasma presents a unique opportunity for its detection. Interest- ingly, we observed that cell fixation and permeabilization following lipid staining permitted differentiation of LNCaP cells from PBMC. Both LNCaP ce[r]

A revolution in cancer genetics has occurred in the past 25 years. Identification of cancer genes has led to a better understanding of the tumorigenesis process and has had important repercussions on all fields of biology. In spite of[r]

Molecular characterization of circulating tumor cells (CTC) is promising for personalized medicine. We aimed to identify a CTC gene expression profile predicting outcome to first-line aromatase inhibitors in metastatic breast cancer (MBC) patients.

Leukemia is a cancer of blood and bone marrow cells, causing about 300,000 deaths worldwide. Photodynamic therapy (PDT) is a promising alternative for the treatment of malignant tumors. KillerRed is a genetically encoded red fluorescent protein photosensitizer (PS).

What are the ‘‘unmet needs’’ of mammalian gene expression systems? Media formulation continues to be an important area, with the goals of reducing costs, enhancing production yields, as well as increasing product sialylation (e.g., [32]). Unfortunately, commercial improvements in media[r]

This paper investigates models of Flexible AC Transmission Systems (FACTS) and applications of FACTS devices for improving the rotor angle stability. FACTS devices are applicable in shunt connection Static Var Compensator (SVC), in series connection Thyristor-Controlled Series Capacitor (TCSC), or[r]

Esterases are often overexpressed in cancer cells and can have chiral specificities different from that of the corresponding normal tissues. For this reason, ester prodrugs could be a promising approach in chemotherapy.

Nanomedicine is a very promising field and nanomedical drugs have recently been used as therapeutic agents against cancer. In a previous study, we showed that Nanoceria (NCe), nanoparticles of cerium oxide, significantly inhibited production of reactive oxygen species, cell migration and invasion of[r]

Effect of defucosylation on the reactivity with PGM34
The Fuc residue attached via the a 1–2 linkage was removed in order to determine the involvement of this residue in the epitope of PGM34. Oligosaccharides generated from A1-5b by mild acid hydrolysis were separated into fou[r]

exposed to CNT/DNA-Cy5 conjugates for 72 h. After the 72-h incubation, the cells exhibit normal morphology and proliferation (Fig. 3 a). The CNT/DNA-Cy5 conjugates were observed within the cytoplasm (Fig. 3 b–d), indicating that the conjugates were effectively transported into the as[r]

R ECTAL C ROHN ’ S D ISEASE
Crohn’s limited to the rectum is an unusual pattern of disease. The surgical management of Crohn’s proctitis mandates proctectomy. The extent of the proximal resection however is controversial. Performing an abdominal perineal resection with an[r]

7
Future Perspectives
In this chapter, we have provided a summary of mouse models available for studies involving cell cycle regulation during the early events of meiosis. Thus far, more than 200 mouse models affecting fertility have been generated that affect the male or fe[r]

Received: 8 June 2009 / Accepted: 24 September 2009 / Published online: 24 November 2009
Ó to the authors 2009
Abstract As the field of nanotechnology continues to grow, evaluating the cytotoxicity of nanoparticles is important in furthering their application within b[r]

Space tourism industry plays an important role in the global development.
Economical, social and educational benefits.
The recent growth of activities towards developing passenger space travel is very promising. 
Neil Armstrong:
“one small step for man... one giant leap for mankind”.

Results dT-QX exhibits varied cytotoxicity on liver cancer cells that have different levels of TK1 and TYMP In addition to the reported selective activity of dT-QX [29], significant vari[r]

From independence to 1860, the U.S. grew and developed industry. This period was critical to development of the modern enterprise. Railroads and the telegraph allowed firms to grow for economies of scale and scope. Managers were required for large, complex organizations. Quality of life for people w[r]

only partial protection against hA-mediated toxicity. Moreover, intracellular ROS accumulation is observed only in a small number of hA-treated RINm5F cells, although it is possible that hA-induced increase in ROS levels is either transient or occurs shortly before cell death. The su[r]

Polyhydroxylsteroids or oxysterols are oxygenated derivatives of steroids and constitute a family of compounds with various biological activities. Especially, oxysterols have been shown to exhibit cytotoxicity in a number of cell lines, including smooth muscle cells, fibroblasts and vascular endothe[r]