DNA DAMAGE AND APOPTOSIS IN FETAL AND OVARIAN RESERVE OOCYTES

strategy to sensitize cells to DNA damage will be entertained.AbbreviationsBARD1, BRCA1-associated RING domain protein; BRCA1, breast cancer susceptibility gene 1; BRCT, BRCA1 C-terminus;CRM1, chromosome region maintenance 1; DSB, double strand breaks; EGFR, epidermal growth factor rec[r]

both sides of the injury, which results in damage exci-sion, and (c) synthesis and ligation of a stretch ofDNA to repair the gap created by the excision. InTCR, stalled RNA polymerase II acts as a marker forrecognition of the lesion by the DNA repair machin-ery. Wi[r]

11. Sreedhara, A., Freed, J.D. & Cowan, J.A. (2000) Efficient deoxyribonucleases. Greater than 50-million-fold rate enhancement inenzyme-like DNA cleavage. J. Am. Chem. Soc. 122, 8814–8824.12. Je_zzowska-Bojczuk, M., Les´niak, W., Bal, W., Kozłowski, H.,Gatner, K., Jezierski, A., Sobcza[r]

for example, the burn involves the maternal abdominal wall, alternative methods of fetal assessment, such as fetal kick counts (alone or in response to acoustic stimulation) [26] or a modifi ed FBP [16,42,43] using vaginal ultrasound, may be necessary. Whenever abdominal burns ar[r]

Fig. 1. TSA decreases hormone-induced transcription of the MMTVpromoter, and increases basal transcription in the absence of hormone.(A) The reporter DNA construct, the pMMTV:M13 used for injectionwith the primer used for primer extension analysis of DMS methyla-tion protection[r]

Denite treatment of stage IA2-Ib1 of cervical cancer is radical hysterectomy with total pelvic and Para aortic lymphadenectomy which is an effective therapy with low recurrence rate in early stages, but the main problem is infertility (Abu-Rustum et al., 2005; 2006). Pre-invasive lesi[r]

25. Zhang J, Wang B: Arsenic trioxide (As(2)O(3)) inhibits peritoneal invasionof ovarian carcinoma cells in vitro and in vivo. Gynecol Oncol 2006,103:199-206.26. Nakagawa Y, Akao Y, Morikawa H, Hirata I, Katsu K, Naoe T, Ohishi N, Yagi K:Arsenic trioxide-induced apopto[r]

DNA Repair − On the Pathways to Fixing DNA Damage and Errors 4 4.1 Multiple pathways in parallel with Fen1 Fen1 is a major, but not the only enzyme that can create ligatable nicks directly from flap structures (Harrington & Lieber, 1994; Murante et al., 19[r]

inhibit tumor growth and metastasis of human melanoma.Cancer Res 2002, 62:5106-5114.46. Higuchi T, Orita T, Nakanishi S, Katsuya K, Watanabe H, Yamasaki Y,Waga I, Nanayama T, Yamamoto Y, Munger W, Sun H, Falk R, Jen-nette J, Alcorta D, Li H, Yamamoto T, Saito Y, Nakamura M: Molec-ular cloning[r]

N-terminal part compared to the N-terminus of human PR130. The open reading frame ends seven amino acids after the putative splicing site. Thestop codon (vertical line) is followed by a polyadenylation signal and a poly(A) tail. Arrows shown on the longest clone represent 5¢-RACE strategyof X[r]

Transfection A GFP/NS1 expression vector under the control of the ecdysone response element previously con-structed in our laboratory was utilized for these ex-periments as previously described (20). Briefly, HepG2 cells were grown on glass coverslips in hepa-tocyte wash medium (Invitr[r]

32-36 w> 36 wp for interaction air pollution by gestation < 0.0001Odds ratio14 d 3 m 6 m 9 mConception Pregnancywww.milieu-en-gezondheid.be0.81.01.21.4<32 w32-36 w> 36 wp for interaction air pollution by gestation < 0.0001Odds ratioIndependent odds ratios for small[r]

hybrid screen. The amino- and carboxy-terminal moieties of hGld2 (hGld2N and hGld2C, respectively) were expressed as fusion proteins withGal4BD, and used together for the screen. (B) Growth of transformed yeast in selective medium. Bait plasmids (left) were mated with pre[r]

b cells are already present during intrauterine life, and datafrom the literature con®rm that the glucokinase gene isFig. 3. Ontogenesis of glucokinase mRNA in rat pancreatic islets andliver. Total RNA from pancreatic islets (A) and liver (B) of 21-day-oldfetal (F-21), 5, 10,