GLOBAL GENE EXPRESSION PROFILING IDENTIFIES ALDH2, CCNE1 AND SMAD3 AS POTENTIAL PROGNOSTIC MARKERS IN UPPER TRACT UROTHELIAL CARCINOMA

Current knowledge about the molecular properties and prognostic markers of upper tract urothelial carcinoma (UTUC) is sparse and often based on bladder urothelial carcinoma (UC), which is thought to share common risk factors with UTUC.

Zhai, G., Ding, C., Stankovich, J., Cicuttini, F., Jones, G. (2005). The genetic contribution to longitudinal changes in knee structure and muscle strength: a sibpair study. Arthritis and Rheumatism, 52, 2830–2834.259G.S. Lynch (ed.), Sarcopenia – Age-Related Muscle Wasting a[r]

mRNA extraction and real-time PCR analysis
Fadu cells (1.5 × 10 5 cells/ml, 1 ml) were cultured in 6-well culture plates for 24 h. Then, cells were transfected with mock RNAi and 1 × 10 7 TU/ml STK33-RNAi lenti- viral vector for 48 h and cells were treat[r]

Emerging technologies, such as gene expression profiling, are increasingly valued as powerful tools for new biomarker identification [20–24]. Data from gene expression profiling is generated from the analysis of hybridization microarray, which[r]

7. Visse R, Nagase H: Matrix metalloproteinases and tissue inhibitors ofmetalloproteinases: structure, function, andbiochemistry. Circ Res 2003,92(8):827-39.8. Wang H, Zhang Y, Heuckeroth RO: PAI-1 deficiency reduces liver fibrosisafter bile duct ligation in mice through activat[r]

Talin-1 is a cytoskeletal protein that plays an important role in tumourgenesis, migration and metastasis in several malignant tumors. The aim of this study was to evaluate the expression and prognostic value of Talin-1 in nasopharyngeal carcinoma (NPC).

There is an unmet clinical need for better prognostic and diagnostic tools for renal cell carcinoma (RCC). CUBN expression is highly specific to RCC and loss of the protein is significantly and independently associated with poor prognosis. CUBN expression in ccRCC provides a promising positive progn[r]

To analyze the expression of karyopherin alpha 2 (KPNA2) in upper tract urothelial carcinoma (UTUC) and to investigate whether the KPNA2 expression provides additional prognostic information following radical nephroureterectomy (RNU).

Systematic analysis of cancer gene-expression patterns using high-throughput transcriptional profiling technologies has led to the discovery and publication of hundreds of gene-expression signatures. However, few public signature values have been cross-validated over multiple studies for the predict[r]

distance threshold t. It keeps decreasing along the iteration.For example, the initial value is assigned to be 0.25, whichmeans high correlation according to Cohen’s rule of thumb[17]. Each iteration decreases this threshold by 0.05 until itreaches 0.1, then it remains constant at 0.1. This techniqu[r]

BioMed CentralPage 1 of 7(page number not for citation purposes)Virology JournalOpen AccessReviewThe state of the art of adeno-associated virus-based vectors in gene therapyRenata dos Santos Coura and Nance Beyer Nardi*Address: Department of Genetics, Universidade Federal[r]

BioMed CentralPage 1 of 7(page number not for citation purposes)Virology JournalOpen AccessReviewThe state of the art of adeno-associated virus-based vectors in gene therapyRenata dos Santos Coura and Nance Beyer Nardi*Address: Department of Genetics, Universidade Federal[r]

patients progression. The aim of this study was to determine whether PAR1 expression could beused as predictor of metastases and mortality.Methods: In a cohort of patients with infiltrating ductal carcinoma studied longitudinally since 1996and until 2[r]

SLC52A3 was recently identified as a susceptibility gene for esophageal squamous cell carcinoma (ESCC). However, associations between the single nucleotide polymorphisms (SNPs) rs13042395 (C > T) and rs3746803 (G > A) in SLC52A3 and risk, tumor characteristics and survival of ESCC patients remain in[r]

The KEYNOTE-028 trial (NCT02054806), an ongoing, multi-cohort, phase 1b trial to test the efficacy of pem- brolizumab in PD-L1 positive solid tumors, released data in the 2015 European Cancer Congress 26 on 24 patients with biliary tract cancer (BTC) who had PD-L1 posit[r]

Patients with transitional cell carcinoma of the urothelial tract (TCCU) who fail initial platinum-based chemotherapy for advanced disease represent a challenge in daily clinical practice. Vinflunine is approved by the European Medicine Agency (EMA) but, up to now, limited experience has been report[r]

KIF23 (kinesin family member 23) is a kinesin-like motor protein and plays an important role in cytokinesis. In search for genes associated with hepatocellular carcinoma (HCC) by cDNA microarray, we found that KIF23 was upregulated in HCC tissues.

Mucoepidermoid carcinoma (MEC) arises from multiple organs and accounts for the most common types of salivary gland malignancies. Currently, patients with unresectable and metastatic MEC have poor long-term clinical outcomes and no targeted therapies are available.

cancer. Genes Chromosomes Cancer 2005, 42(2):193-199.6. Dobashi Y, Goto A, Fukayama M, Abe A, Ooi A: Overexpression of cdk4/cyclin D1, a possible mediator of apoptosis and an indicator ofprognosis in human primary lung carcinoma. Int J Cancer 2004,110(4):532-541.7. Fang W[r]

The purpose of this study was to evaluate invasive and metastatic potential of urothelial cancer by investigating differential expression of various clock genes/proteins participating in the 24 h circadian rhythms and to compare these gene expressions with transcription of other cancer-associated ge[r]