HETEROGENEOUS BCR-ABL1 SIGNAL PATTERNS IDENTIFIED BY FLUORESCENCE IN SITU HYBRIDIZATION ARE ASSOCIATED WITH LEUKEMIC CLONAL EVOLUTION AND POORER PROGNOSIS IN BCR-ABL1 POSITIVE LEUKEMIA
Tìm thấy 10,000 tài liệu liên quan tới tiêu đề "Heterogeneous BCR-ABL1 signal patterns identified by fluorescence in situ hybridization are associat...":
Heterogeneous BCR-ABL1 signal patterns identified by fluorescence in situ hybridization are associated with leukemic clonal evolution and poorer prognosis in BCR-ABL1 positive leukemia
Although extensive use of tyrosine kinase inhibitors has resulted in high and durable response rate and prolonged survival time in patients with BCR-ABL1 positive chronic myeloid leukemia (CML) and acute leukemia, relapse and drug resistance still remain big challenges for clinicians.
BÁO CÁO KHOA HỌC SPATIO TEMPORAL DISTRIBUTION OF FATTY ACID BINDING PROTEIN 6 FABP6 GENE TRANSCRIPTS IN THE DEVELOPING AND ADULT ZEBRAFISH DANIO RERIO PPTX
fabp6 gene and examined its conserved gene synteny with the human, rat and mouse FABP6 ⁄ Fabp6 genes. Using the LN54 panel of radiation hybrids [21] and specific primers to exon 2 and intron 2, repectively (see Fig. 1 and Experimental procedures), the[r]
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BÁO CÁO KHOA HỌC BLUE SHIFT OF CDSE ZNS NANOCRYSTAL LABELS UPON DNA HYBRIDIZATION PPT
In this paper we report the specific labeling and imaging of Arabidopsis tissue sections by the use of distinguisha- ble QD-oligonucleotide conjugates. After hybridization, regions within the Arabidopsis flower like pistil, leaves or pollen could be depicted respectively[r]
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MUC1 in lung adenocarcinoma: Crosssectional genetic and serological study
Mucin 1 (MUC1) contributes to the growth and metastasis of various cancers, including lung cancer, and MUC1 gene length polymorphisms are associated with susceptibility to lung cancer and its prognosis. In contrast, the association between rs4072037, a single nucleotide polymorphism in MUC1, and lun[r]
HYPOXIA ALTERS THE RECRUITMENT OF TROPOMYOSINS INTO THE ACTIN STRESS FIBRES OF NEUROBLASTOMA CELLS
Neuroblastoma is the most common extracranial solid tumor of childhood. The heterogeneous microenvironment of solid tumors contains hypoxic regions associated with poor prognosis and chemoresistance. Hypoxia implicates the actin cytoskeleton through its essential roles in motility, invasion and prol[r]
Colorectal carcinomas with mucinous differentiation are associated with high frequent mutation of KRAS or BRAF mutations, irrespective of quantity of mucinous component
Mucinous adenocarcinoma (MAC) is a distinct type of colorectal cancer (CRC) associated with poor response to treatment and poorer prognosis. MAC is diagnosed by WHO definition when the extracellular mucin is more than 50% of the lesion.
DETECTION OF LOW GRADE MOSAICISM IN TURNER SYNDROME USING FLUORESCENCE IN SITU HYBRIDIZATION
The high in-utero lethality of 45,X condition has led to the hypothesis that most of the liveborn 45,X individuals have low frequency of mosaicism. Most, if not all, liveborn 45,X Turner syndrome individuals are mosaic and have some normal cells in some tissues or pos[r]
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Increased PD-1-positive macrophages in the tissue of gastric cancer are closely associated with poor prognosis in gastric cancer patients
Programmed cell death 1 (PD-1) is one of the immune checkpoint molecules that negatively regulate the function of T cells. Although recent studies indicate that PD-1 is also expressed on other immune cells besides T cells, its role remains unclear.
Histone deacetylases (HDACs) guided novel therapies for T-cell lymphomas
T-cell lymphomas are a heterogeneous group of cancers with different pathogenesis and poor prognosis. Histone deacetylases (HDACs) are epigenetic modifiers that modulate many key biological processes. In recent years, HDACs have been fully investigated for their roles and potential as drug targets i[r]
Exploring the value of new preoperative inflammation prognostic score: White blood cell to hemoglobin for gastric adenocarcinoma patients
The platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), and neutrophil to lymphocyte ratio (NLR) reflect the systematic inflammatory response, with some evidence revealing that they are associated with poorer survival in patients with gastric cancer.
NDN AND CD1A ARE NOVEL PROGNOSTIC METHYLATION MARKERS IN PATIENTS WITH HEAD AND NECK SQUAMOUS CARCINOMAS
HPV-associated HNSCCs have a distinct etiologic mechanism and better prognosis than those with non-HPV associated HNSCCs. However, even within the each group, there is heterogeneity in survival time. Here, we test the hypothesis that specific candidate gene methylation markers (CCNA1, NDN, CD1A, DCC[r]
Interaction of hnRNP K with MAP 1B-LC1 promotes TGF-β1-mediated epithelial to mesenchymal transition in lung cancer cells
Heterogeneous ribonucleoproteins (hnRNPs) are involved in the metastasis-related network. Our previous study demonstrated that hnRNP K is associated with epithelial-to-mesenchymal transition (EMT) in A549 cells.
Statistical classifiers for diagnosing disease from immune repertoires: A case study using multiple sclerosis
Deep sequencing of lymphocyte receptor repertoires has made it possible to comprehensively profile the clonal composition of lymphocyte populations. This opens the door for novel approaches to diagnose and prognosticate diseases with a driving immune component by identifying repertoire sequence patt[r]
INCIDENCE OF BONE METASTASES IN PATIENTS WITH SOLID TUMORS: ANALYSIS OF ONCOLOGY ELECTRONIC MEDICAL RECORDS IN THE UNITED STATES
Bone metastases commonly occur in conjunction with solid tumors, and are associated with serious bone complications. Population-based estimates of bone metastasis incidence are limited, often based on autopsy data, and may not reflect current treatment patterns.
PROGNOSTIC IMPACT OF CIRCULATING TUMOR CELL APOPTOSIS AND CLUSTERS IN SERIAL BLOOD SAMPLES FROM PATIENTS WITH METASTATIC BREAST CANCER IN A PROSPECTIVE OBSERVATIONAL COHORT
We explored whether apoptotic CTCs, CTC clusters and leukocytes attached to CTCs are associated with breast cancer subtype and prognosis at base-line BL and in follow-up FU blood samples[r]
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Low prevalence of p16-positive HPV-related head-neck cancers in Thailand: Tertiary referral center experience
There has been a sharp rise in the incidence of human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma (OPSCC) in many countries. Patients with HPV-positive OPSCC have a more favorable prognosis compared with HPV-negative OPSCC, leading to investigation and adoption of de-escala[r]
Longitudinal alterations in health-related quality of life and its impact on the clinical course of patients with advanced hepatocellular carcinoma receiving sorafenib treatment
This study aimed to identify the health-related quality of life (HRQOL) domains associated with prognosis by assessing longitudinal alterations in HRQOL in patients with advanced hepatocellular carcinoma receiving sorafenib.
VIMENTIN AND KI67 EXPRESSION IN CIRCULATING TUMOUR CELLS DERIVED FROM CASTRATE-RESISTANT PROSTATE CANCER
High circulating tumor cell (CTC) counts are associated with poor prognosis in advanced prostate cancer, and recently CTC number was suggested to be a surrogate for survival in metastatic castrate-resistant prostate cancer (mCRPC).
Pancreatic tumor in type 1 autoimmune pancreatitis: A diagnostic challenge
The co-occurrence of type 1 autoimmune pancreatitis (AIP) and pancreatic tumor (PaT) has been previously reported. Pure AIP cases have favorable prognosis and are primarily treated with steroids, while AIP cases with PaT are associated with poor prognosis where the primary management is pancreatic r[r]
TÌM HIỂU KỸ THUẬT LAI HUỲNH QUANG TẠI CHỖ FISH (FLORESCENCE IN SITU HYBRIDIZATION) TRÊN VI SINH VẬT
Tìm hiểu kỹ thuật lai huỳnh quang tại chỗ FISH (Florescence In Situ Hybridization) trên vi sinh vật