GENE EXPRESSION PROFILING REVEALS ACTIVATION OF THE FA/BRCA PATHWAY IN ADVANCED SQUAMOUS CERVICAL CANCER WITH INTRINSIC RESISTANCE AND THERAPY FAILURE
Tìm thấy 10,000 tài liệu liên quan tới tiêu đề "Gene expression profiling reveals activation of the FA/BRCA pathway in advanced squamous cervical ca...":
MK-2206 SENSITIZES BRCA-DEFICIENT EPITHELIAL OVARIAN ADENOCARCINOMA TO CISPLATIN AND OLAPARIB
Platinum resistance is a major obstacle in the treatment of epithelial ovarian cancer (EOC). Activation of the AKT pathway promotes platinum resistance while inhibition of AKT sensitizes chemoresistant cells. Patients with BRCA mutant EOC, and thus a defect in the homologous recombination (HR) repai[r]
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IL6 GENOTYPE, TUMOUR ER-STATUS, AND TREATMENT PREDICTED DISEASE-FREE SURVIVAL IN A PROSPECTIVE BREAST CANCER COHORT
In breast cancer, high levels of the inflammatory cytokine interleukin-6 (IL-6) have been associated with disease-free survival and treatment resistance. Increased serum levels of IL-6 have been correlated with increased levels of NF-κβ and aromatase expression in adipose tissue.
NEOADJUVANT CHEMOTHERAPY VERSUS NEOADJUVANT CHEMORADIOTHERAPY FOR LOCALLY ADVANCED OESOPHAGEAL SQUAMOUS CELL CARCINOMA: A SINGLE-CENTRE, OPEN-LABEL, RANDOMIZED, CONTROLLED, CLINICAL TRIAL (H
Neoadjuvant therapy plus oesophagectomy has been accepted as the standard treatment for patients with potentially curable locally advanced oesophageal cancer. No completed randomized controlled trial (RCT) has directly compared neoadjuvant chemotherapy and neoadjuvant chemoradiation in patients with[r]
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THE PROGNOSTIC VALUE OF EGFR OVEREXPRESSION AND AMPLIFICATION IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA
EGFR overexpression and gene amplification were evaluated for their potential prognostic significance. The Kaplan-Meier survival curves for patients in the different scoring systems of EGFR expression or gene numbers are shown in Figs. 3[r]
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Verbascoside promotes apoptosis by regulating HIPK2–p53 signaling in human colorectal cancer
Reportedly, theHIPK2 – p53 apoptotic pathway is down- regulated in different human cancer cells [36-42]. In inves- tigating the mechanisms that underpin VB-promoted apoptosis, we first learned that both in CRC tumors and cells, VB elevated HIPK2 prote[r]
DOSE-VOLUME HISTOGRAM PREDICTORS OF CHRONIC GASTROINTESTINAL COMPLICATIONS AFTER RADICAL HYSTERECTOMY AND POSTOPERATIVE INTENSITY MODULATED RADIOTHERAPY FOR EARLY-STAGE CERVICAL CANCER
The small bowel is one of the critical organs involved in gastrointestinal complications in cervical cancer treated with postoperative intensity modulated radiotherapy. Even with modest doses of radiation therapy (45-50Gy), the risk of severe injury from postoperative radiation therapy is between 5%[r]
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SUMMARY OF PHD THESIS: CLINICAL, SUBCLINICAL FEATURES AND RESISTANCE TO TYROSINE KINASE INHIBITOR OF LUNG CANCER PATIENTS WITH EGFR MUTATIONS
To describe the clinical and subclinical features of lung cancer patients with EGFR mutations before TKIs therapy and in the relapsed period. To identify the T790M mutation and MET amplification in patients with lung cancer and EGFR-TKIs resistance and the relationship with clinical and subclinical[r]
B4GALT1 EXPRESSION PREDICTS PROGNOSIS AND ADJUVANT CHEMOTHERAPY BENEFITS IN MUSCLEINVASIVE BLADDER CANCER PATIENTS
The expression alterations of B4GALT1 have been noted in some types of cancer and they are related to cancer cell proliferation, invasiveness, metastasis, and drug resistance. We aimed to establish the expression of B4GALT1 in bladder cancer and its connection to patient outcomes, as well as forecas[r]
LIM AND SH3 PROTEIN 1 REGULATES CELL GROWTH AND CHEMOSENSITIVITY OF HUMAN GLIOBLASTOMA VIA THE PI3K/AKT PATHWAY
LIM and SH3 protein 1 (LASP1) is upregulated in several types of human cancer and implicated in cancer progression. However, the expression and intrinsic function of LASP1 in glioblastoma (GBM) remains unclear.
UTILIZING NATIVE FLUORESCENCE IMAGING, MODELING AND SIMULATION TO EXAMINE PHARMACOKINETICS AND THERAPEUTIC REGIMEN OF A NOVEL ANTICANCER PRODRUG
Success of cancer prodrugs relying on a foreign gene requires specific delivery of the gene to the cancer, and improvements such as higher level gene transfer and expression. CNOB (3.3 mg/kg) was injected iv in mice implanted with humanized ChrR6 (HChrR6)-expressing 4T1 tumors.
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A RETROSPECTIVE OBSERVATIONAL STUDY OF CLINICOPATHOLOGICAL FEATURES OF KRAS, NRAS, BRAF AND PIK3CA MUTATIONS IN JAPANESE PATIENTS WITH METASTATIC COLORECTAL CANCER
The mutation in KRAS exon 2 is a validated biomarker of resistance to anti-epidermal growth factor receptor (EGFR) therapy in metastatic colorectal cancer (mCRC). Several reports have confirmed associations of other RAS mutations with resistance to anti-EGFR therapy. However, the impact of BRAF and[r]
APOPTOSIS INHIBITOR-5 OVEREXPRESSION IS ASSOCIATED WITH TUMOR PROGRESSION AND POOR PROGNOSIS IN PATIENTS WITH CERVICAL CANCER
The apoptosis inhibitor-5 (API5), anti-apoptosis protein, is considered a key molecule in the tumor progression and malignant phenotype of tumor cells. Here, we investigated API5 expression in cervical cancer, its clinical significance, and its relationship with phosphorylated extracellular signal-r[r]
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Expressions of MUC1 and vascular endothelial growth factor mRNA in blood are biomarkers for predicting efficacy of gefitinib treatment in non-small cell lung cancer
Gefitinib, an EGFR-tyrosine kinase inhibitor, significantly improve prognosis in patients with advanced non-small cell lung cancer (NSCLC). The aim of this study was to evaluate the usefulness of MUC1 and vascular endothelial growth factor (VEGF) mRNA expression in peripheral blood as means of predi[r]
THE RHO-KINASE INHIBITOR HA-1077 SUPPRESSES PROLIFERATION/MIGRATION AND INDUCES APOPTOSIS OF UROTHELIAL CANCER CELLS
Activation of Rho, one of the small GTPases, and its major downstream target Rho-kinase (ROCK) promotes the development and metastasis of cancer. We previously showed that elevation of Rho and ROCK expression was associated with tumor invasion, metastasis, and an unfavorable prognosis in patients wi[r]
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PROGNOSTIC SIGNIFICANCE OF ANNEXIN A2 AND ANNEXIN A4 EXPRESSION IN PATIENTS WITH CERVICAL CANCER
The annexins (ANXs) have diverse roles in tumor development and progression, however, their clinical significance in cervical cancer has not been elucidated. The present study was to investigate the clinical significance of annexin A2 (ANXA2) and annexin A4 (ANXA4) expression in cervical cancer.
URG4 OVEREXPRESSION IS CORRELATED WITH CERVICAL CANCER PROGRESSION AND POOR PROGNOSIS IN PATIENTS WITH EARLY-STAGE CERVICAL CANCER
Clinical evidence has indicated that URG4 is elevated in patients with certain types of cancer. Its expression has been shown to be associated with tumour aggressiveness in osteosarcomas, prostate cancer and neuroblastomas [11-13]. These[r]
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THE AUTOPHAGY GABARAPL1 GENE IS EPIGENETICALLY REGULATED IN BREAST CANCER MODELS
The GABARAP family members (GABARAP, GABARAPL1/GEC1 and GABARAPL2 /GATE-16) are involved in the intracellular transport of receptors and the autophagy pathway. We previously reported that GABARAPL1 expression was frequently downregulated in cancer cells while a high GABARAPL1 expression is a good pr[r]
Deconvolution of diffuse gastric cancer and the suppression of CD34 on the BALB/c nude mice model
In this article, we aimed to characterize the diffuse gastric cancer cells with MRI and transcriptomic data. We hypothesized that gene expression pattern is associated with the phenotype of the cells and that the heterogeneous enhancement pattern and the high tumorigenicity of SNU484 can be modulate[r]
Aggregation of lipid rafts activates c-met and c-Src in non-small cell lung cancer cells
their first diagnosis. Radiotherapy is one of the basic treatments for unresectable NSCLC, but the resistance to radiation greatly limits the curative effect of radiotherapy. Currently, cellular survival pathways that regulate DNA damage repair after radio[r]
EXPRESSION AND CLINICAL SIGNIFICANCE OF C-MET IN ADVANCED ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Our aim was to investigate the expression of c-Met in advanced esophageal squamous cell carcinoma in four phase II trials who had tumor tissues from archival in our center and analyze the correlations between c-Met expression and clinical features.
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