FUNCTIONAL LUNG AVOIDANCE FOR INDIVIDUALIZED RADIOTHERAPY (FLAIR): STUDY PROTOCOL FOR A RANDOMIZED, DOUBLE-BLIND CLINICAL TRIAL

In the current trial, the response rate (the primary endpoint) or PFS (a secondary endpoint) can serve as a surrogate endpoint for OS. A study of advanced/recur- rent gastric cancer examined whether PFS could serve as a surrogate endpoint for O[r]

The primary study objective is to investigate the efficacy of topical imiquimod 5 % cream for the treatment of high-grade CIN and to develop a biomarker profile to predict clinical response to imiquimod treatment. Secondary study objectives are to assess treatment[r]

Trial registration: Clinicaltrial.gov: NCT02041871.
Keywords: Liver resection, Hepatectomy, Immunonutrition, Liver metastases, HCC, Cholangiocarcinoma
Background
Hepatic resection is the treatment of choice for selected patients with benign and malignant hepatobilia[r]

This paper describes about a study protocol of phase I/II multicenter prospective clinical trial evaluating the feasibility and efficacy of the hybrid of intracavitary and interstitial brachytherapy (HBT) for locally advanced uterine cervical cancer patients.

Methods: This is a multicenter, double-blind, randomized controlled trial in female breast cancer patients
undergoing mastectomy, with or without axillary clearance. Exclusion criteria consist of breast conserving therapy, direct breast reconstruction and incapac[r]

gratefully acknowledge the excellent technical as-sistance of Dr. Enrique Bravo, Dr. Carlos Porras, Dr. Julia Alvarez, Dr. Guadalupe Romero, Dr. Juana Trejo, Dr. Adriana Dominquez, Dr. Alberto Martinez, Febe Huitron, Genoveva Cordero, Marcela Gonzalez and Alma Lorena Rodriguez.References1. Karyadi E[r]

such that combination of these agents with chemotherapy may reverse this. Indeed,there is pre-clinical evidence of synergy between doxorubicin and raf inhibition. Ina vascular endothelial model, resistance to doxorubicin is, at least in part, medi-ated via fibroblast growth factor (FGF)-mediat[r]

doses. Pooled IVIg may be an alternative to TIG, but the specific antitoxin concentration in this formulation is not standardized. The value of administering antitoxin before wound manipulation or of injecting a dose proximal to the wound or infiltrating the wound is unclear. Additional doses[r]

large number of drugs that have been reported toinfluence muscle tone, very few have been founduseful in clinical practice. The commonly used anti-spastic drugs arebaclofen, benzodiazepines,dantro-lene sodium and tizanidine. The drugs can be usedalone as monotherapy or in combination to reduce[r]

papulopustulöser akne. Z Hautkr 1988;63:374-6. 87 Cambazard F. Clinical efficacy of Velac®, a new tretinoin and clindamycin phosphate gel in acne vulgaris. J Eur Acad Dermatol Venereol 1998;11;S20-S27. 88 Richter JR, Forstrom LR, Kiistala UO, Jung EG. Efficacy of the fixed 1.2% clind[r]

It is well known that women suffer from negative consequences following breast cancer (BC) treatment and that their largely varying needs for rehabilitation are often unmet.

Current evidence supports a diverting stoma in patients undergoing low anterior resection with total mesorectal excision for rectal cancer as it reduces clinical severity of anastomotic leakage. However, relevant stoma morbidity after rectal cancer surgery exists and has a significant impact on qual[r]

of 80 and concluded that patients would benefit from definitive therapy with radiation or chemotherapy [28]. Our study showed that patients with recurrent or advan- ced cancer tolerated treatment well with minimal side ef- fects and obtained good local control based on 7 patients with stage I[r]

patients developed abscess requiring operative drainage.(23)Surgical Options for Chronic Pilonidal DiseaseOperations for chronic pilonidal disease involve excision of the diseased tissue. This may result in a large defect which is difficult to close in an area which is subject t[r]