TOPICAL IMIQUIMOD TREATMENT OF HIGH-GRADE CERVICAL INTRAEPITHELIAL NEOPLASIA (TOPIC TRIAL): STUDY PROTOCOL FOR A RANDOMIZED CONTROLLED TRIAL

The “TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia” (TOPIC) trial was stopped preliminary, due to lagging inclusions. This study aimed to evaluate the treatment efficacy and clinical applicability of imiquimod 5% cream in high-grade cervical intraepithelial neoplasia ([r]

Cervical dysplasia (cervical intraepithelial neoplasia (CIN)) is caused by Human Papillomavirus (HPV) and is most common in women of reproductive age. Current treatment of moderate to severe CIN is surgical.

127 Thiboutot DM, Shalita AR, Yamauchi PS, Dawson C, Kerrouche N, Arsonnaud S, Kang S. Adapalene gel, 0.1%, as maintenance therapy for acne vulgaris: a randomized, controlled, investigator-blind follow-up of a recent combination study. Arch Dermatol.[r]

Hamad et al. BMC Public Health 2011, 11:51http://www.biomedcentral.com/1471-2458/11/51© 2011 Hamad et al; licensee BioMed Central Ltd. This is an Open Acc ess article distri buted under t he terms of the Creative C ommonsAttribution License (http://creativecommons.org/licenses/by/2.0), which[r]

Treatment with tumor-Infiltrating Lymphocytes (TIL) is an innovative therapy for advanced melanoma with promising clinical phase I/II study results and likely beneficial cost-effectiveness. As a randomized controlled trial on the effectiveness of TIL therapy in advanced melanoma compared to ipilimum[r]

Breast cancer (BC) is the most frequent cancer occurring in women across the world. Its mortality rate in low-middle income countries (LMICs) is higher than in high-income countries (HICs), and in Indonesia BC is the leading cause of cancer deaths among women.

Fatigue is a common and debilitating symptom for patients with incurable cancer receiving systemic treatment with palliative intent. There is evidence that non-pharmacological interventions such as graded exercise therapy (GET) or cognitive behaviour therapy (CBT) reduce cancer-related fatigue in di[r]

Early detection of oesophageal cancer improves outcomes; however, the optimal strategy for identifying patients at increased risk from the pre-cancerous lesion Barrett’s oesophagus (BE) is not clear.

When both VAs are patent and one symptomatic VA has a definite stenotic lesion with the uninvolved larger VA supplying sufficient blood flow to the BA, corrective surgery may be effective [1]. The surgical approach to atherosclerotic lesions at the origin of the VA includes trans-subcl[r]

Chapter 133. Tetanus (Part 4) Tetanus: Treatment General Measures The goals of therapy are to eliminate the source of toxin, neutralize unbound toxin, and prevent muscle spasms while monitoring the patient's condition and providing support—especially respiratory support—until r[r]

earlier line of therapy, non-progression on prior irinotecan-based chemotherapy, and dose-reductions while on treatment. In this real-world study, safety was com- parable to that seen in the NAPOLI-1 study. The main toxicities seen were fatigue, gastrointestinal toxicit[r]

Deftereos et al. [33] analyzed miR-143 and miR-21 in a large set of samples with different stages of disease. Despite increasing down-regulation of miR-143 with increasing
severity of histology had been previously reported [47, 48], such pattern was not confirmed[r]

[PMID: 16371037] Hebert PC et al: A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. N Engl J Med 340:409, 1999 [PMID: 9971864] Hillyer CD et al (eds): Blood Banking and Transfusion Medicine: Basic Principles and Prac[r]

Self-management is becoming essential for breast cancer survivors, but evidence about the effectiveness of self-management support (SMS) intervention is lacking. To address this issue, we developed a theory-based SMS intervention, the ‘EMPOWER’, aimed at empowering breast cancer survivors. Here we d[r]

Discussion
The primary endpoints in the G-SOX study were a PFS with a non-inferiority margin of 1.30 and an OS with a non-inferiority margin of 1.15 [9]. Domestic phase I/II trials of oxaliplatin to treat colon cancer used a recom- mended dos[r]

Two-thirds of U.S. adult women are overweight or obese. High body mass index (BMI) and adult weight gain are risk factors for a number of chronic diseases, including postmenopausal breast cancer.

observational study. Lancet 1999, 353:878-882.6. Rohlmann A, Klockner C, Bergmann G: [The biomechanics of kyphosis].Orthopade 2001, 30:915-918.7. Schwab F, Lafage V, Patel A, Farcy JP: Sagittal plane considerations andthe pelvis in the adult patient. Spine (Phila Pa 1976)[r]

Ethical Committees of the Academic Medical Centre,Amsterdam, The Netherlands, Sahlgrenska UniversityHospital, Göteborg, Sweden, Kings Hospital, London,UK, and Wake Forest University School of Medicine, Win-ston-Salem, North Carolina, USA.A quality assessmenthas been made and app[r]

This paper describes about a study protocol of phase I/II multicenter prospective clinical trial evaluating the feasibility and efficacy of the hybrid of intracavitary and interstitial brachytherapy (HBT) for locally advanced uterine cervical cancer patients.

Cervical cancer screening is not recommended for women who underwent hysterectomy with no history of cervical intraepithelial neoplasia (CIN) of grade 2 or higher. We aimed to determine the cervical cancer screening rate in Korean women who underwent hysterectomies and compare it to that in women wi[r]