A PROSPECTIVE, SINGLE-ARM, PHASE II CLINICAL TRIAL OF INTRAOPERATIVE RADIOTHERAPY USING A LOW-ENERGY X-RAY SOURCE FOR LOCAL ADVANCED LARYNGOCARCINOMA (ILAL): A STUDY PROTOCOL
Tìm thấy 10,000 tài liệu liên quan tới tiêu đề "A prospective, single-arm, phase II clinical trial of intraoperative radiotherapy using a low-energy...":
A prospective, single-arm, phase II clinical trial of intraoperative radiotherapy using a low-energy X-ray source for local advanced Laryngocarcinoma (ILAL): A study protocol
Laryngocarcinoma (LC), in most cases a squamous cell carcinoma, accounts for 1 ~ 5% of the incidence of all tumors. At present, laryngocarcinoma is mainly managed with the integration of surgery and radioand chemo-therapies. The current development trend of treatment is to improve the local control[r]
PHASE II TRIAL OF ERIBULIN MESYLATE AS A FIRSTOR SECOND-LINE TREATMENT FOR LOCALLY ADVANCED OR METASTATIC BREAST CANCER: A MULTICENTER, SINGLE-ARM TRIAL
Eribulin mesylate is currently indicated as a sequential monotherapy to be administered after two chemotherapeutic regimens, including anthracycline and taxane treatments, for treatment of metastatic breast cancer.
PHASE II STUDY OF METFORMIN FOR REDUCTION OF OBESITY-ASSOCIATED BREAST CANCER RISK: A RANDOMIZED CONTROLLED TRIAL PROTOCOL
Two-thirds of U.S. adult women are overweight or obese. High body mass index (BMI) and adult weight gain are risk factors for a number of chronic diseases, including postmenopausal breast cancer.
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BÁO CÁO KHOA HỌC NATURAL POLYPHENOLS AS PROTEASOME MODULATORS AND THEIR ROLE AS ANTI CANCER COMPOUNDS DOC
strong oxidative stress and aging induce both subtle andsevere alterations in proteasome biology [73].The proteasome is involved in multiple cellular path-ways, regulating cell proliferation, cell death, neuro-pathological events and drug resistance in humantumour cells. Therefore, it seems to be an[r]
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A PHASE I/II CLINICAL TRIAL FOR THE HYBRID OF INTRACAVITARY AND INTERSTITIAL BRACHYTHERAPY FOR LOCALLY ADVANCED CERVICAL CANCER
This paper describes about a study protocol of phase I/II multicenter prospective clinical trial evaluating the feasibility and efficacy of the hybrid of intracavitary and interstitial brachytherapy (HBT) for locally advanced uterine cervical cancer patients.
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PROGNOSTIC FACTOR OF EARLY DEATH IN PHASE II TRIALS OR THE END OF ‘SUFFICIENT LIFE EXPECTANCY’ AS AN INCLUSION CRITERION? (PREDIT MODEL)
Optimizing patient selection is a necessary step to design better clinical trials. ‘Life expectancy’ is a frequent inclusion criterion in phase II trial protocols, a measure that is subjective and often difficult to estimate. The aim of this study was to identify factors associated with early death[r]
A PHASE II STUDY OF ENDOSTATIN IN COMBINATION WITH PACLITAXEL, CARBOPLATIN, AND RADIOTHERAPY IN PATIENTS WITH UNRESECTABLE LOCALLY ADVANCED NON-SMALL CELL LUNG CANCER
Endostatin inhibits the pro-angiogenic action of basic fibroblast growth factor and vascular endothelial growth factor in different human cancers. This study assessed the efficacy of endostatin combined with concurrent chemoradiotherapy of non-small cell lung cancer (NSCLC).
COLORECTAL LIVER METASTATIC DISEASE: EFFICACY OF IRREVERSIBLE ELECTROPORATION - A SINGLE-ARM PHASE II CLINICAL TRIAL (COLDFIRE-2 TRIAL)
Irreversible electroporation (IRE) is a novel image-guided tumor ablation technique that has shown promise for the ablation of lesions in proximity to vital structures such as blood vessels and bile ducts.
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PROSPECTIVE PHASE II TRIAL OF EVEROLIMUS IN PIK3CA AMPLIFICATION/MUTATION AND/OR PTEN LOSS PATIENTS WITH ADVANCED SOLID TUMORS REFRACTORY TO STANDARD THERAPY
We designed a single-arm, open-label phase II trial of everolimus in PIK3CA amplification/mutation and/or PTEN loss patients with advanced solid tumors refractory to standard therapy. The study did not meet its primary objective of demonstrating the anti-tumor activity of everolimus in PIK3CA amplif[r]
Study protocol of a phase II clinical trial (KSCC1501A) examining oxaliplatin + S-1 for treatment of HER2-negative advanced/ recurrent gastric cancer previously untreated with chemotherapy
In Japan, oxaliplatin + S-1 (SOX) (oxaliplatin dose: 100 mg/m 2
) and SP were compared in the G-SOX study, but SOX did not demonstrate non-inferiority in com- parison to SP [9]. A recent application sought approval of oxaliplatin based on data in the public domain [in Japan, t[r]
) and SP were compared in the G-SOX study, but SOX did not demonstrate non-inferiority in com- parison to SP [9]. A recent application sought approval of oxaliplatin based on data in the public domain [in Japan, t[r]
Stereotactic prostate adaptive radiotherapy utilising kilovoltage intrafraction monitoring: The TROG 15.01 SPARK trial
This paper describes the multi-institutional prospective phase II clinical trial, SPARK: Stereotactic Prostate Adaptive Radiotherapy utilizing Kilovoltage Intrafraction Monitoring (KIM). KIM is a real-time image guided radiotherapy technology being developed and clinically pioneered for prostate can[r]
COCSTOM TRIAL: STUDY PROTOCOL FOR A RANDOMISED TRIAL COMPARING COMPLETENESS OF ADJUVANT CHEMOTHERAPY AFTER EARLY VERSUS LATE DIVERTING STOMA CLOSURE IN LOW ANTERIOR RESECTION FOR RECTAL
Current evidence supports a diverting stoma in patients undergoing low anterior resection with total mesorectal excision for rectal cancer as it reduces clinical severity of anastomotic leakage. However, relevant stoma morbidity after rectal cancer surgery exists and has a significant impact on qual[r]
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Nanoliposomal irinotecan with fluorouracil for the treatment of advanced pancreatic cancer, a single institution experience
earlier line of therapy, non-progression on prior irinotecan-based chemotherapy, and dose-reductions while on treatment. In this real-world study, safety was com- parable to that seen in the NAPOLI-1 study. The main toxicities seen were fatigue, gastrointestinal toxicities and[r]
IMPROVED OUTCOMES IN COLON AND RECTAL SURGERY PART 23 PDF
significant healthcare resources and workhours.Historical PerspectivePilonidal disease is believed to have been first described by Mayo (1) in 1833. The term “pilonidal,” originating from the Latin words for “hair” and “nest,” was not coined until 1880 by Hodges.(2) The disease became more wi[r]
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INDUCTION CHEMOTHERAPY FOLLOWED BY RADIOTHERAPY VERSUS CONCURRENT CHEMORADIOTHERAPY IN ELDERLY PATIENTS WITH NASOPHARYNGEAL CARCINOMA: FINDING FROM A PROPENSITY-MATCHED ANALYSIS
To date, no guideline is proposed for elderly nasopharyngeal carcinoma (NPC) due to lack of prospective clinical trials. The present study comparing the survivals and toxicities in elderly NPC patients received either induction chemotherapy followed by radiotherapy(IC + RT) or concurrent chemoradiot[r]
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PROTOCOL OF THE PANCALYZE TRIAL: A MULTICENTER, PROSPECTIVE STUDY INVESTIGATING THE TUMOR BIOMARKERS CXCR4, SMAD4, SOX9 AND IFIT3 IN PATIENTS WITH RESECTED PANCREATIC ADENOCARCINOMA TO
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies today with an urgent need for novel therapeutic strategies. Biomarker analysis helps to better understand tumor biology and might emerge as a tool to develop personalized therapies.
TOPical Imiquimod treatment of high-grade cervical intraepithelial neoplasia (TOPIC trial): Study protocol for a randomized controlled trial
treatment by LLETZ.
Follow-up visits are anchored to the start of the treat- ment (either imiquimod or LLETZ). Cytological assess- ment will be performed by two independent trained cytology analysts, according to the Papanicolaou system. In case of inconsistent results, a cons[r]
Follow-up visits are anchored to the start of the treat- ment (either imiquimod or LLETZ). Cytological assess- ment will be performed by two independent trained cytology analysts, according to the Papanicolaou system. In case of inconsistent results, a cons[r]
NGHIÊN CỨU ĐẶC ĐIỂM LÂM SÀNG CẬN LÂM SÀNG BỆNH TĨNH MẠCH PHỔI VỀ LẠC CHỖ HOÀN TOÀN Ở TRẺ EM
echocardiographic diagnosis of total anomalous pulmonary venous connection,British Heart Journal, 53, pp: 525-34.8. Karamlou Tara, Gurofsky Rebecca, et al (2007), Factors associated with mortalityand reoperation in 377 children with total anomoalous pulmonary venousconnection, Circulation, 11[r]
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A PROSPECTIVE PHASE I STUDY OF HYPOFRACTIONATED NEOADJUVANT RADIOTHERAPY FOR LOCALLY ADVANCED GASTRIC CANCER
Previous studies have reported that neoadjuvant chemoradiotherapy can downstage the advanced gastric cancer. However, no studies are available on the application of hypo-radiotherapy to neoadjuvant radiotherapy.
A PHASE I STUDY OF NEDAPLATIN, PEMETREXED AND THORACIC INTENSITY-MODULATED RADIOTHERAPY FOR INOPERABLE STAGE III LUNG ADENOCARCINOMA
Concurrent chemotherapy and radiation is the standard treatment for unresectable stage III Lung adenocarcinoma. However, no optimal concurrent chemotherapeutic regimen has been described. This study aimed to assess concurrent pemetrexed, nedaplatin and thoracic intensity-modulated radiotherapy follo[r]