PROGNOSTIC AND CLINICAL IMPACT OF PIK3CA MUTATION IN GASTRIC CANCER: PYROSEQUENCING TECHNOLOGY AND LITERATURE REVIEW

In this study, we determined the genetic profiles of 126 Japanese esophageal cancer patients by NGS and AQUA using DNA from FFPE samples. Our cohort was non-biased consecutive cases, which consisted mostly of ESCC, but also of those with non-ESCC histology. Amplicon-based MPS identified mutations in[r]

We designed a single-arm, open-label phase II trial of everolimus in PIK3CA amplification/mutation and/or PTEN loss patients with advanced solid tumors refractory to standard therapy. The study did not meet its primary objective of demonstrating the anti-tumor activity of everolimus in PIK3CA amplif[r]

The relationships among PIK3CA mutations, medication use and tumor progression remains poorly understood. Aspirin use post-diagnosis may modify components of the PI3K pathway, including AKT and mTOR, and has been associated with lower risk of breast cancer recurrence and mortality.

After analysis of minor RAS mutations (KRAS exon 3, 4/NRAS) in the FIRE-3 and PRIME studies, an expanded range of RAS mutations were established as a negative predictive marker for the efficacy of anti-EGFR antibody treatment. BRAF and PIK3CA mutations may be candidate biomarkers for anti-EGFR targe[r]

Many urothelial carcinomas (UC) contain activating PIK3CA mutations. In telomerase-immortalized normal urothelial cells (TERT-NHUC), ectopic expression of mutant PIK3CA induces PI3K pathway activation, cell proliferation and cell migration.

Đồ án tốt nghiệp 1 GVHD: Trương Thị Minh Hạnh Chương 7TÍNH XÂY DỰNG7.1. Tính nhân lực lao động7.1.1. Chế độ làm việc của nhà máyDo điều kiện khí hậu ở nước ta chỉ thuận lợi cho việc trồng mía và thu hoạch theo mùa. Do đó, các nhà máy đường đều sản xuất theo mùa vụ, mỗi vụ khoảng 6 đến 7 tháng, từ th[r]