CLOSTRIDIUM DIFFICILE INFECTION IN PATIENTS WITH CANCER

Bezlotoxumab (Zinplava) for Prevention of Recurrent Clostridium difficile Infection
The FDA has approved the fully human monoclonal antibody bezlotoxumab (Zinplava – Merck) for use with antibacterial drug treatment to reduce recurrence of Clostridium difficile...
Nusinersen (Spinraza) for Spinal M[r]

A major impediment in the treatment of ovarian cancer is the relapse of chemotherapy-resistant tumors, which occurs in approximately 25% of patients. A better understanding of the biological mechanisms underlying chemotherapy resistance will improve treatment efficacy through genetic testing and nov[r]

Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide. The only drug currently approved for clinical use in the treatment of advanced HCC is sorafenib. However, many patients with HCC show reduced sensitivity to sorafenib during treatment.

Dysphagia or difficulty in swallowing affects quality of life for most patients with head and neck cancer. SIP SMART – [Swallowing Intervention Package: Self-Monitoring, Assessment, Rehabilitation Training] aims to improve post-treatment swallowing outcomes through a targeted and tailored pre-treatm[r]

The prognostic significance of TP53 concurrent mutations in patients with epidermal growth factor receptor (EGFR)- or anaplastic lymphoma kinase (ALK)- mutated advanced non–small-cell lung cancer (NSCLC) who received EGFR-tyrosine kinase inhibitors (TKIs) or ALK-TKIs based targeted therapy remains c[r]

Cervical cancer mainly caused by human papilloma virus infection, is the leading cancer in Indian women and the second most common cancer in women worldwide. Almost 80% of cases occurred in developing countries. The objectives of the study were to assess the knowledge, attitude regarding cervical ca[r]

Cervical cancer is caused by high-risk Human Papillomavirus (hr-HPV) infection associated with cofactors that has been analyzed as predictors of the remission or persistence of cytological abnormalities remission or persistence.

Correct identification of the EGFR c.2369C>T p.(Thr790Met) variant is key to decide on a targeted therapeutic strategy for patients with acquired EGFR TKI resistance in non-small cell lung cancer. The aim of this study was to evaluate the correct detection of this variant in 12 tumor tissue specimen[r]

Patients with metastatic renal cell cancer (mRCC) are commonly treated with the tyrosine kinase inhibitor sunitinib, which blocks signalling from vascular endothelial growth factor (VEGF) - and platelet-derived growth factor-receptors, inhibiting development of new blood vessels.

Thalassemia is an autosomal recessive disease causing haemolytic anaemia. The ideal treatment of these patients involves regular, 2-4 weekly blood transfusions. The major complications by this treatment are the transmission of transfusion acquired infections such as Hepatitis B virus infection, Hepa[r]

This study aimed to evaluate the efficacy and the safety of polyethylene glycol conjugated granulocyte colony-stimulating factor (PEG-G-CSF) for preventing neutropenia in metastatic colorectal cancer (mCRC) patients that received fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) plus[r]

INTRODUCTION OF THESIS

1. Background:
Lung cancer is one of the common cancers. The disease has the highest incidence and mortality among cancers, most commonly seen in the elderly especially over 60 years old. The majority of lung cancer is related to secondhand and passive smoking and has over[r]

with higher inspiratory concentration of CO2, which decreased at increasing flow rates [5].Similar findings were reported in a bench and healthy volunteers study with an increase ininspired concentration of CO2 when the gas flow rate was reduced below 30 l/min. It isnoteworthy t[r]

... with limited infection of animals SPF lambs, advantages availability animals experimental particular haemolytica have would ready in animals P of animal animals sheep, of in haemolytica P with proved... number and costly A model seasonal laboratory low and cost infection of available the small a[r]

To investigate the alterations in plasma concentration of dopamine in patients with Parkinson’s disease. Subjects and methods: Changes in plasma concentration of dopamine were analyzed to find its correlations and clinical features in 45 patients with Parkinson’s disease (PD group) and 40 healthy pe[r]

In conclusion, PCa patients with a PSA level < 4 ng/ml have more favorable tumor characteristics at diagnosis and receive more benefit from active treatment. However, those patients with advanced TNM stage and high Gleason grade should be paid more attention in clinical application.

To evaluate the plasma testosterone level in male patients with chronic kidney disease stage III - V, pre-dialysis. Subjects and methods: A cross-sectional study with a study group of 118 chronic kidney disease patients, pre-dialysis.

Atrial FibrillationSymptomatic AF:Only “the tip of the Iceberg”Symptomatic AFSilent AFRung nhĩ làm tăng tỷ lệ tử vong&amp; nguy cơ ĐQ tái phátTử VongCumulative probability of recurrence (%)• 3,530 patients with first-ever ischaemic stroke• AF was confirmed by ECG in 869 p[r]

Persistent infection with high-risk Human Papillomavirus (HPVs) is associated with the development of cervical cancer. The transforming capacity of these viruses relies on the cooperative action of the E6 and E7 viral oncoproteins.

The objective of this study was to investigate real-world EGFR mutation testing in patients with metastatic non-small cell lung cancer (NSCLC) upon progression on first−/second-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKI), and subsequent treatments received.