NON-CODING RNA

The pathogenesis of multiple myeloma involves complex genetic and epigenetic events. This study aimed to investigate the role and clinical relevance of the long non-coding RNA (lncRNA), metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in multiple myeloma.

ncRNAs. Additionally, two possible riboswitches for thiaminepyrophosphate (cluster 2) [38] and cobalamin (cluster 101)[39] were excluded from further experimental investigations.In the remaining clusters, all candidate sequences fromMED4 were tested by Northern hybridization. This restric-tion was i[r]

Keywords: Long non-coding RNA, Tumor suppressor, Gastric carcinoma, Epithelial-to-mesenchymal transition Background
Gastric cancer is the fourth leading cause of cancer death, with a high mortality worldwide, especially in Asia [1,2]. Unfortunately, gastric cancer is difficult to cur[r]

RUNX1 overlapping RNA (RUNXOR) is a long non-coding RNA that has been indicated as a key regulator in the development of myeloid cells by targeting runt-related transcription factor 1 (RUNX1). Myeloidderived suppressor cells (MDSCs) are a heterogeneous population of cells consisting of immature gran[r]

Recently studies have demonstrated that the long non-coding RNA (lncRNA) metastasis associated lung adenocarcinoma transcript 1 (MALAT1) may participate in the development and progression of lung cancer. In this study, we hypothesized that genetic variant of this lncRNA may affect the prognosis of l[r]

Acute promyelocytic leukemia (APL) is characterized by the reciprocal translocation t(15;17), which fuses PML with retinoic acid receptor alpha (RARα). Although PML-RARα is crucially important for pathogenesis and responsiveness to treatment, the molecular and cellular mechanisms by which PML-RARα e[r]

Dysregulation of the long non-coding RNA small nucleolar RNA host gene 16 (lncRNA SNHG6) has been found in multiple cancers. However, a definite conclusion on the clinical value of lncRNA SNHG6 expression in human cancers has not been determined.

MicroRNAs (miRNAs) are short non-coding RNA molecules that play a critical role in mRNA cleavage and translational repression, and are known to be altered in many diseases including breast cancer. MicroRNA-10a (miR-10a) has been shown to be deregulated in various cancer types.

MicroRNAs are single-stranded non-coding RNA sequences of 18 - 24 nucleotides in length. They play an important role in post-transcriptional regulation of gene expression. Evidences of microRNA acting as promoter/suppressor of several diseases including cancer are being unveiled.

Circular RNAs are a new class of endogenous non-coding RNA that can function as crucial regulators of diverse cellular processes. The diverse types of circular RNAs with varying cytogenetics in cancer have also been reported.

Long non-coding RNA MALAT1 is significantly upregu- lated in gastric cancer
We analyzed the microarray results of the levels of 192
“ other non-coding RNAs ” to find previously annotated lncRNAs with differential expressional patterns between paired cancer and adjacen[r]

Nc886 is a 102 bp non-coding RNA transcript initially classified as a microRNA precursor (Pre-miR-886) , later as a divergent homologue of the vault RNAs (vtRNA 2–1) and more recently as a novel type of RNA (nc886).

The competing endogenous RNA (ceRNA) networks of long non-coding RNAs (lncRNAs) and microRNAs (miRs) have aroused wide concerns. The study aims to investigate the roles of lncRNA DANCRassociated ceRNA network in the growth and behaviors of colon cancer (CC) cells.

Augusto LF Marino 1 , Adriane F Evangelista 1 , René AC Vieira 2 , Taciane Macedo 1 , Ligia M Kerr 3 ,
Lucas Faria Abrahão-Machado 3 , Adhemar Longatto-Filho 1,5,6,7 , Henrique CS Silveira 1 and Marcia MC Marques 1,4*
Abstract
Background: MicroRNAs (miRNAs) are small, non-coding[r]

The long non-coding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) plays a crucial role in cancer progression, which is regulated by the interferon regulatory factor-1 (IRF1) and up-streaming Akt activation.

scriptional evidence can support finding potential protein-coding genes in the intergenic regions. Thus the idea of com-bining the evidence from the sequence- and function-basedanalyses lends itself to not just gene characterization but alsogene prediction. Notice, however, genes that are sile[r]

Rui Yang 1,3 † , Yongjun Chen 1 † , Cong Tang 2 , Hongbo Li 1 , Bing Wang 1 , Qun Yan 1 , Junbo Hu 1* and Shengquan Zou 1*
Abstract
Background: MicroRNAs are endogenous non-coding RNAs that play important roles in a wide variety of biological
processes such as apoptosis, developm[r]

BioMed CentralPage 1 of 7(page number not for citation purposes)Virology JournalOpen AccessShort reportHeterologous influenza vRNA segments with identical non-coding sequences stimulate viral RNA replication in transStella SF Ng, Olive TW Li, Timothy KW Cheung, J S Malik Peiris and Leo[r]

Fax: 81 75 251 5381Tel: 81 75 251 5381E-mail: mkatsuya@koto.kpu-m.ac.jp(Received 6 December 2010, revised 7January 2011, accepted 11 January2011)doi:10.1111/j.1742-4658.2011.08018.xNOX is the catalytic subunit of NADPH oxidase, the superoxide-generat-ing enzyme. Among several isoforms of NOX, NOX4 i[r]

wouldonlygobacktothepointof recapitulation. Put an-other way, the earliest proteins phylogenetically speaking willbe the first proteins that were coded for. Presumably, if thesesequences can still be detected in modern genomes, theywould t end t o b e r elatively s hort and somewhat indistincttraces[r]