ADIPOSE DERIVED STROMAL CELLS CYTOKINE EXPRESSION AND IMMUNE CELL CONTAMINANTS

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CHAPTER 7
CONCLUSION AND FUTURE LINE OF WORK
Human adipose tissue is a rich source of stromal cells. This work has shown that adipose tissue isolated from lipoaspirates of human donors can be processed to yield a population of stromal cells<[r]

This is the first study to provide a thorough investiga- tion of the CD4 + T cell profile in CFS/ME patients through the assessment of cytokine secretion and regu- latory protein levels in particular VPACR2 receptors and FoxP3 expression. Cytokines are soluble prot[r]

Although these results indicate that monocytes are considerably more susceptible to NP-induced cytotoxicity than other immune cell types tested, it is important to note that these differences may be related to distinctions in cell- culture conditions. While T cells, B <[r]

CD248 is a cell surface glycoprotein, highly expressed by stromal cells and fibroblasts of tumors and inflammatory lesions, but virtually undetectable in healthy adult tissues. CD248 promotes tumorigenesis, while lack of CD248 in mice confers resistance to tumor growth.

We previously reported that IL-6 and transglutaminase 2 (TG2) were expressed in more aggressive basal-like breast cancer cells, and TG2 and IL-6 expression gave these cells stem-cell-like phenotypes, increased invasive ability, and increased metastatic potential.

Mannose-binding lectin (MBL) acts in the innate immune response to Helicobacter pylori. Interleukin 8 (IL-8) is a potent cytokine produced by gastric epithelial cells in response to H. pylori.

The most commonly used eukaryotic cells for recombinant protein expression are derived from mammalian or insect tissues and utilize either viral- or plasmid-based vehicles to transduce y[r]

Glioma is a common malignant tumours in the central nervous system (CNS), that exhibits high morbidity, a low cure rate, and a high recurrence rate. Currently, immune cells are increasingly known to play roles in the suppression of tumourigenesis, progression and tumour growth in many tumours.

The impact of inflammatory factors, such as IL-6, might also be of interest in the context of breast cancer cells possessing a hybrid epithelial/mesenchymal (E/M) or a partial EMT phenotype [47]. Both EMT and its re- verse, mesenchymal-to-epithelial transition (MET), are hallmarks of c[r]

Growing evidence exists that the neoplastic stromal cell population (GCTSC) within giant cell tumors (GCT) originates from mesenchymal stem cells (MSC). In a previous study we identified a microRNA signature that differentiates between these cell types.

Modification of insulin signaling in
a 1,3-FucT-VII-transfected cells
The effect of the above-mentioned changes in insulin- signaling molecules on transduction of the insulin sig- nal was further studied in a 1,3-FucT-VII-transfected cells following serum starvation. Phosphorylatio[r]

Cancer therapies that kill cancer cells without affecting normal cells is the ultimate mode of treating cancers. The VP3, an avian virus-derived protein, can specifically initiate cell death through several signal transduction pathways leading to apoptosis. In cancer, chemoresistance and cell surviv[r]

Many urothelial carcinomas (UC) contain activating PIK3CA mutations. In telomerase-immortalized normal urothelial cells (TERT-NHUC), ectopic expression of mutant PIK3CA induces PI3K pathway activation, cell proliferation and cell migration.

cific proteases (USP ⁄ UBPs) and ubiquitin C-terminal hydrolases.
The role of ubiquitin ligases as modulators of cen- tral and peripheral tolerance has brought attention to this system as one of the key components of a complex regulatory network designed to maintain an active immun[r]

strongly activated antigen-specific T cell immune re- sponse by survivin and MUC1 pulsing and SOCS1 si- lencing and stimulation of TLR signaling.
The vaccination-related AEs were reported to be under lower grade category within the 28-day period. Therefore, thi[r]

Regulatory T cells (Tregs), particularly the CD4+ CD25+ Foxp3+ Tregs, down regulate immunity and promote tumor cell growth by directly suppressing CD8+ and CD4+ T cells. Alternatively they can promote tumor growth by generating interleukin-10 (IL-10) and transforming growth factor β (TGFβ) in situ,[r]

implanted with SM1 tumors and treated with PLX3397 and PLX4032. In these immunodeficient mice, there was no an- titumor activity of PLX3397 compared to mice receiving vehicle control. Furthermore, the tumor growth curve of the combined treatment group overlapped with the PLX4032 alon[r]

Cells of the innate immune system play important roles in the progression of prion disease after peripheral infection. It has been found in vivo and in vitro that the expression of the cellular prion protein (PrP c ) is up-regu- lated on stimulation of immune ce[r]

When using organ and primary cultures, it is important to consider the heterogenous nature of the cell types in the tissue i.e., stromal elements and lymphoid cells in addition to the co[r]

50 TRANG 8 DANH MỤC CHỮ VIẾT TẮT AB Antibiotic/Antimycotic - Kháng sinh ASCs Adipose-derived Stem Cells - Tế bào gốc mỡ bFGF Basic fibroblast growth factor – Nhân tố tăng trưởng nguyên b[r]