GENERATION OF LENTIVIRAL VECTORS FOR USE IN SKELETAL MUSCLE RESEARCH

this fragment does not bear the binding site for titin-N2A (Fig. 1C). After photobleaching, the recoveryspeed of DNter2 is significantly slower than the recov-ery speed of CARP, suggesting that the long C-termi-nal CARP fragment is more efficiently bound to titinafter cleavage by[r]

in very old rats. J Gerontol A Biol Sci Med Sci, 56, B224–33.128 O. DelbonoCarrasco, M., Jaimovich, E., Kemmerling, U., Hidalgo, C. (2004). Signal transduction and gene expression regulated by calcium release from internal stores in excitable cells. Biological Research, 37, 701–[r]

Koopman, R., Pennings, B., Zorenc, A. H., van Loon, L. J. (2007b). Protein ingestion further aug-ments S6K1 phosphorylation in skeletal muscle following resistance type exercise in males. The Journal of Nutrition, 137, 1836–1842.311Exercise and Nutritional Interven[r]

Mosher, D. S., Quignon, P., Bustamante, C. D., Sutter, N. B., Mellersh, C. S., Parker, H. G., Ostrander, E. A. (2007). A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs. PLoS Genetics, 3, e79.Nakao, A., Afrakhte, M., More[r]

Integrins in the Development and Pathology of Skeletal Muscle 13 the ECM and the actin cytoskeleton, the assortment of proteins that are associated with each complex differs, and it is likely that specific signaling pathways elicit different biochemical responses.[r]

Ljubicic, V., Joseph, A. M., Saleem, A., Uguccioni, G., Collu-Marchese, M., Lai, R. Y., Nguyen, L. M., Hood, D. A. (2009). Transcriptional and post-transcriptional regulation of mitochondrial biogenesis in skeletal muscle: Effects of exercise and aging. Biochimica[r]

aralar1 levels were higher in auricular than ventricularFig. 1. Comparison of expression pattern of citrin and aralar1 during murine embryonic development. Whole embryos from embryonic day (E) 11(A–E, a–e), in toto E18 isolated organs (H–I, h–i), or transverse E18 cryosta[r]

time, it should be noted that, unlike myostatin, whichis predominantly expressed in skeletal muscle cells andis not present in C. elegans, plants or flies, the RNF13gene is broadly expressed in many other tissues and isevolutionarily conserved among metazoans. There[r]

Int. J. Med. Sci. 2006, 3 84International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2006 3(3):84-91 ©2006 Ivyspring International Publisher. All rights reserved Research paper Skeletal muscle sodium glucose co-transporters in older adults with type[r]

chrome c release in isolated mitochondria. Proceedings of the National Academy of Sciences of the United States of America, 95, 14681–14686.Nickson, P., Toth, A., Erhardt, P. (2007). PUMA is critical for neonatal cardiomyocyte apoptosis induced by endoplasmi[r]

5. The intracellular abundance of key proteins (e.g. enzymes, cyclins ortranscription factors) is tightly regulated so that major biological processes areprecisely controlled.A major challenge is to understand both general and tissue/organ-specificmechanisms, which are responsible for[r]

identified, which would complicate the selection of patients for genetic screening. Although integrins and the DPC provide a similar link between laminin and the actin cytoskeleton, ablation of the two protein complexes leads to a different spectrum of muscle defec[r]

IGF-I, but also on the pattern of growth factor receptor expression (Rubin and Baserga 1995). Whether or not aging alters IGF-I receptor density in skeletal muscle, and what impact this may have during muscle repair is unclear.164 L.E. Gosselin5 Duchenne Muscular D[r]

later, is required for skeletal muscle hypertrophy to occur following 12 weeks of intervention in the elderly. However, the absence of any hypertrophy in the control group receiving the same supplement 2 h after cessation of each exercise bout[r]

85% depending on the conditions of the strength measure (e.g., limb, contraction angle, velocity, and type) (Thomis et al. 1998a, 2004; Perusse et al. 1987a, b; Huygens et al. 2004a; Karlsson et al. 1979; Reed et al. 1991; Thomis et al. 1998a; Arden and Spector 1997; Zhai et al. 2004; Roppone[r]

These results mirror what has recently been found for other highly heritable traits: genome-wide association studies are finding genes with relatively small influence that in no way explain the overall genetic influence predicted by heri-tability estimates (Maher 2008). This could refl[r]

(H2O2) (Palomero and Jackson 2010). The generation of specific RONS, including superoxide, nitric oxide and hydroxyl radicals by muscle were then described (Reid et al. 1992a,b; O’Neill et al. 1996; Balon and Nadler 1994; Kobzik et al 1994).Cells are required to preserve a delic[r]

446 C. McFarlane et al.Shyu, K. E., Lu, M. J., Wang, B. W., Sun, H. Y., Chang, H., (2006) Myostatin expression in ventricular myocardium in a rat model of volume-overload heart failure. European Journal of Clinical Investigation, 36, 713–719.Siciliano, G., Tessa, A., Renn[r]

skeletal muscle with aging (Larsson and Ansved 1995), its prevalence in human and animal models of aging remains to be determined.Some studies, particularly in the last decade, have focused on the mechanisms underlying neuromuscular impairments in old age. S[r]

IMAGEJ software (n = 3 plates per condition). Each value is the mean ± SE. *Significantdifference versus control group (P < 0.05). Phosphorylation of Akt and S6K1 was induced within 10 min, and was maintained for at least60 min. Altered distributions of TSC1 and TSC2 prote[r]