ROLE OF OXIDATIVE STRESS IN ED UNRAVELING THE MOLECULAR MECHANISM

Gastric cancer (GC) is one of the most frequent malignant tumors and the molecular mechanism underlying its proliferation remains far from completely understood. Although accumulating evidence shows that abnormal expression of microRNA (miRNA) is involved in tumorigenesis, the role of specific miRNA[r]

Currently, most agents are developed to be computationally powerful. However, asthe multi-agent systems grow more and more complicated nowadays, coordination amongmultiple intelligent entities is inevitable. The study of the inter-agent relationships needsto be further explored.[r]

effect could be indicative of diamide-induced stimula-tion of methionine transformation into Cys, a pathwayin which Hcys represents an intermediate. Given thewell-known action of Hcys as a pro-atherogenic andcardiovascular risk factor, the fact that diamide treat-ment (an[r]

The results of our study, which is the largest study pub- lished to date that evaluated the relationship between glo- bal methylation and colorectal adenoma development by comparing LINE-1 DNA methylation levels in normal appearing colon tissue biopsies between col[r]

Hepatocyte nuclear factor-3β (HNF-3β) plays a critical role in hepatocyte differentiation and controls liver-specific gene expression during the development of hepatocellular carcinoma (HCC), but the molecular basis of this process has not been fully elucidated.

Gastric cancer is the fourth most common cancer and the second most deadly cancer worldwide. Study on molecular mechanisms of carcinogenesis will play a significant role in diagnosing and treating gastric cancer.

The role of stress signals in regulating gastric cancer initiation and progression is not quite clear. It is known that stress signals modulate multiple processes such as immune function, cell migration and angiogenesis.

The role of the parents in the past and nowadays The role of parents in the family is extremely important. This role changes over time. Và bài viết này là một bài mẫu cho topic: The role of the parents in the past and nowadays

we next tested the release of cytochrome C - an important initiator step for the activation of caspases. Western blot results for cytochrome C revealed a sustained release of cytochrome C from 1.5 h onwards with maximal release at 6 h, indicating initiation of[r]

H3K27me3 histone marks shape the inhibition of gene transcription. In prostate cancer, the deregulation of H3K27me3 marks might play a role in prostate tumor progression. Our findings point to epigenetic mark H3K27me3 as an important event in prostate carcinogenesis and progression. The results repo[r]

Orthodenticle homeobox 1 (OTX1) is a transcription factor that plays an important role in various human cancers. However, the function of OTX1 in laryngeal squamous cell carcinoma (LSCC) is largely unknown. We aimed to explore the roles of OTX1 in LSCC and its possible molecular mechanism.

Metals including iron, copper and zinc are essential for physiological processes yet can be toxic at high concentrations. However the role of these metals in the progression of cancer is not well defined. Here we study the anti-tumor activity of the metal chelator, TPEN, and define its mechanism of[r]

Discussion
In the present study, we examined the role of specific miRs, miR-21 and Let-7a in aberrantly expressed STAT3 signaling during cervical carcinogenesis. STAT3 was tar- geted by different experimental approaches i.e. silencing the expression[r]

Identification of genes regulated by the KEAP1-NRF2- CUL3 axis in HNSCC
In order to identify the genes regulated by the KEAP1- NRF2-CUL3 axis in HNSCC, we focused on the identifica- tion of differentially expressed genes by analyzing <[r]

EGFR gene copy variation
The average gene copy number per cell and the EGFR-to- chromosome 7 ratio for the major FISH patterns are listed in Additional file 2: Table S2. EGFR FISH-positive was seen in 29 (30.2 %) cases. The EGFR genes were amplified i[r]

this disorder. Yap1 cellular distribution was not affected by cTpxI defici-ency and by mitochondrial dysfunction, in spite of the observed expressionalterations of several Yap1-target genes, indicating alternative mechanismsof Yap1 activation ⁄ deactivation. Therefore, we[r]

Cancer development is mediated by oxidative stress and inflammation, which may correlate with metabolic disorders. The aim of this study was to evaluate antioxidant vitamins status and metabolic parameters in patients with oral cancer according to tumor-node-metastasis (TNM) stages.

The aim of this study was to explore the efficacy and define mechanisms of action of PRIMA-1MET as a TP53 targeted therapy in soft-tissue sarcoma (STS) cells. Methods: We investigated effects of PRIMA-1MET on apoptosis, cell cycle, and induction of oxidative stress and autophagy in a panel of 6 STS[r]

Cotton is the very important commercial and cash crop, it is a very much necessary to improve the Superior agronomic traits to withstand against biotic and abiotic stress in the field and fiber qualities to meet requirement of advance spinning technology. Cotton improvement through conventional bree[r]

Cisplatin (CP), an effective anticancer agent, carries the risk of impairing testicular function leading to infertility. The present study aimed at evaluating the protective effect of A. hydaspica ethyl acetate extract (AHE) against CP-induced oxidative stress and testicular injuries in rats.