GROWTH FACTOR

Bucana CD, Pollock RE: Characterization of 11 human sarcoma cell strains:evaluation of cytogenetics, tumorigenicity, metastasis, and production ofangiogenic factors. Cancer 2002, 95(7):1569-1576.14. Nissen LJ, Cao R, Hedlund EM, Wang Z, Zhao X, Wetterskog D, Funa K,Brakenhielm E, Cao Y: Angiogenic f[r]

5. Berdel WE, Danhauser-Riedl S, Steinhauser G, Winton EF: Various humanhematopoietic growth factors (interleukin-3, GM-CSF, G-CSF) stimulateclonal growth of nonhematopoietic tumor cells. Blood 1990, 73:80-83.6. Argüello F, Furlanetto RW, Baggs RB, Graves BT, Harwell SE, Cohen HJ,Frant[r]

Rosengren et al. Arthritis Research & Therapy 2010, 12:R65http://arthritis-research.com/content/12/2/R65Open AccessRESEARCH ARTICLEBioMed Central© 2010 Rosengren et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Com-mons Attributi[r]

MINIREVIEWEpidermal growth factor receptor in relation to tumordevelopment: EGFR-targeted anticancer therapyIsamu OkamotoDepartment of Medical Oncology, Kinki University School of Medicine, Osaka, JapanKRAS mutations and sensitivity totherapy with mAb to epidermal growthfactor receptor[r]

MINIREVIEWHepatocyte growth factor activator (HGFA): its regulationby protein C inhibitorKoji SuzukiDepartment of Molecular Pathobiology, Mie University Graduate School of Medicine, JapanIntroductionProtein C inhibitor (PCI; SERPINA5), a member ofthe plasma serine protease inhibitor (s[r]

stromal cells. Exp Hematol 1993, 21:444-450.14. Sasaki A, Boyce BF, Story B, Wright KR, Chapman M, Boyce R, Mundy GR,Yoneda T: Biphosphonate risedronate reduces metastatic human breastcancer burden in bone in nude mice. Cancer Res 1995, 55:3551-3557.15. Michigami T, Dallas SL, Mundy GR, Yoneda T: In[r]

endothelial growth factor; VEGFR1: VEGF receptor-1; VEGFR2: VEGF receptor-2.AcknowledgementsWe acknowledge ICMR (Indian Council of Medical Research), India, forproviding funds (No. 5/4 - 5/10/Neuro/2005 - NCD - I).Authors’ contributionsPKG Acquisition of data and writing of manuscript.[r]

Helicobacter pylori is an important pathogenic factor in gastric carcinogenesis. Angiogenesis (i.e., the growth of new blood vessels) is closely associated with the incidence and development of gastric cancer. Our previous study found that COX-2 stimulates gastric cancer cells to induce expression o[r]

Renal cell carcinoma (RCC) incidence is highest in highly developed countries and it is the seventh most common neoplasm diagnosed. RCC management include nephrectomy and targeted therapies. Type 1 insulin-like growth factor (IGF-1) pathway plays an important role in cell proliferation and apoptosis[r]

region, a kringle domain, and a catalytic domain(Fig. 2). These domains are homologous to thoseobserved in blood coagulation factor XII (FXII), withan overall amino acid similarity of 39%. Analysis ofgenomic DNA coding for HGFA indicated a relation-ship between HGFA and FXII as well as urokin[r]

as a potent inhibitor of hepatocyte growth factor acti-vator (HGFA), a blood coagulation factor XII-likeserine protease that converts pro-hepatocyte growthfactor (pro-HGF) to the active form [4]. HAI-1was also isolated from human milk in a complex withmatriptase, and potentially[r]

low plasma FGF2 levels prior to surgery have been asso-ciated with an increased risk of recurrence [9-12]. FGF2presence has also been confirmed in studies of sarcomacell-lines [13].FGF2 has been implicated as a player in differentangiogen ic and lymphangiogenic pathways [8]. Nissen etal. reported a[r]

27. Ebner, R. & Derynck, R. (1991) Epidermal growth factor andtransforming growth factor-alpha: differential intracellular rout-ing and processing of ligand-receptor complexes. Cell Regul. 2,599–612.28. Skarpen, E., Johannessen, L.E., Bjerk, K., Fasteng, H.,Guren,[r]

Considering that vWF may act as a key factor in resist- ance to metastasis and also as an inhibitor of angiogenesis, vWF may be a useful progrognostic marker; however, data from other studies have indicated that it may not be a gen- eral marker for all cancer types. Studies of non-small cell[r]

(BsAbs) in a mammalian expression system. We created an IgG-like BsAbin which bi-specific diabodies were fused to the human Fc region via adesigned human rhinovirus 3C (HRV3C) protease recognition site. TheBsAb was purified by protein A affinity chromatography, and the refinedtag-free hEx3-Db was efficie[r]

15. Fukui H, Zhang X, Sun C, Hara K, Kikuchi S, Yamasaki T, et al. IL-22 produced by cancer-associated fibroblasts promotes gastric cancer cell invasion via STAT3 and ERK signaling. Br J Cancer. 2014;111:763 – 71.
16. Lai MS, Cheng YS, Chen PR, Tsai SJ, Huang BM. Fibroblast growth factor[r]

Overexpression or mutation of the epidermal growth factor receptor (EGFR) potently enhances the growth of many solid tumors. Tumor cells frequently display resistance to mechanistically-distinct EGFR-directed therapeutic agents, making it valuable to develop therapeutics that work by additional mech[r]

To evaluate the role of blood vascular endothelial growth factor (VEGF) kinetics in patients with locally advanced esophageal squamous cell carcinoma (ESCC) receiving curative concurrent chemoradiotherapy (CCRT).

(MAb) (cetuximab, matuzumab, panitumumab and trastuzumab) or tyrosine kinase inhibitors (TKI) (gefitinib, erlotinib, lapatinib). Matrix metalloproteinase (MMP), insulin-like growth factor-1 receptor, fibroblast growth factor, c-Met and downstream signaling inhibitors, as[r]

calci) hoặc một số lượng tương đương các sản phẩm từ sữa như phô-mai, sữa chua 4. Sữa gây ung thư. Hiện nay có nhiều ý kiến trái ngược về vấn đề này. Một số nghiên cứu kết luận sữa có thể làm giảm nguy cơ ung thư đại tràng trong khi một số khác thì cho rằng sữa có thể làm tăng nguy cơ ung thư vú ở[r]