PREVENTION AND EARLY DETECTION OF COLORECTAL CANCER

American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection [r]

These proliferation experiments showed that oxalate at concentrations of 20 and 50 μM induces significantly higher rates of proliferation of MCF-7, MDA-MB231 cell lines after three days of treatment as determined by Two-way ANOVA with Holm-Sidak’s multiple compari-[r]

Colorectal cancer is the second most common cause of cancer deaths for both men and women, and the third most common cause of cancer in the U.S. Toxicity of current chemotherapeutic agents for colorectal cancer, and emergence of drug resistance underscore the need to develop new, potentially less to[r]

Blood sample collection and analysis
Non-fasting blood samples are drawn from patients upon recruitment and at all later time-points during a regular clinical visit of the patient. The baseline blood sample is preferably taken before surgery or start of treatment. In ca[r]

The prognosis of pancreatic cancer (PC) is one of the poorest among all cancers, due largely to the lack of methods for screening and early detection. New biomarkers for identifying high-risk or early-stage subjects could significantly impact PC mortality.

Early diagnosis of colorectal cancer (CRC) is clinically critical but technically challenging, especially in a minimal-invasive way. Emerging evidence suggests that exosome-encapsulated microRNAs (miRNAs) is a kind of promising cancer biomarker.

Gastric cancer remains the second leading cause of cancer-related deaths in the world. Successful early gastric cancer detection is hampered by lack of highly sensitive and specific biomarkers. Plasma membrane proteins participate and/or have a central role in the metastatic process of cancer cells[r]

The development of colorectal cancer (CRC) is accompanied by extensive epigenetic changes, including frequent regional hypermethylation particularly of gene promoter regions. There is considerable potential for the development of new DNA methylation biomarkers or panels to improve the sensitivity an[r]

The prevalence of brain metastases (BM) from uterine cancer has recently increased because of the improvement of overall survival (OS) of patients with uterine cancer due to its early detection and improved local control as a result of new effective treatments.

Colorectal cancer screening is key to early detection and thus to early treatment, but uptake is often sub-optimal, particularly amongst lower income groups. It is proposed that the imminent introduction of the single-sample Faecal Immunochemical Test (FIT) in Scotland may lead to increased uptake a[r]

For fighting cancer, earlier detection is crucial. Circulating auto-antibodies produced by the patient’s own immune system after exposure to cancer proteins are promising bio-markers for the early detection of cancer.

Early diagnosis of colorectal cancer (CRC) simplifies treatment and improves treatment outcomes. We previously described a diagnostic metabolomic biomarker derived from semi-quantitative gas chromatographymass spectrometry.

Lead-time bias occurs when a test does not influence the natural history of the disease; the patient is merely diagnosed at an earlier date. When lead-time bias occurs, survival appears increased, but life is not really prolonged. The screening test only prolongs the time the sub[r]

Colorectal cancer is one of the major causes of cancer mortality world-wide. Prevention would improve if at-risk subjects could be identified. The aim of this study was to characterise plasma protein biomarkers associated with the risk of colorectal cancer in samples collected prospectively, before[r]

b Women’s Health Initiative (WHI): alternate-day use of low-dose aspirin (100 mg) for an average of 10 years of treatment does not lower risk of total, breast, colorectal, or other site-
specific cancers. There was a trend toward reduction in risk for lung can[r]

Familial colorectal cancer type X (FCCTX) is a phenotypically defined subset of hereditary colorectal cancer with unknown and potentially heterogeneous genetic aetiology. FCCTX has been characterized as a colorectal cancer-specific syndrome, which we herein challenge by estimating the risk for extra[r]

disease: A population-based study. Cancer 91:854, 2001 [PMID: 11241255]
Bruce WR et al: Possible mechanisms relating diet and risk of colon cancer. Cancer Epidemiol, Biomarkers Prev 9:1271, 2000 [PMID: 11142411]
Chan AT et al: A prospective study [r]

breasts normally look and feel and to notice any changes. The goal, with or without BSE, is to report any breast changes to a doctor or nurse right away.
• Women who choose to use a step-by-step approach to BSE should have their BSE technique reviewed during their physical exam b[r]

Subjects and methods
The WHI consists of several clinical trials and an obser- vational cohort with over 168,000 U.S. healthy, postmen- opausal women aged 50 to 79 enrolled with active follow-up of living participants. The study details of the WHI have been previ[r]

These methods have high absolute sensitivity and potential for au- tomation. HPV seroreactivity to a given type reflects mainly type- specific HPV infection (as measured by DNA detection), but also sig- nals past exposure to other types that may be serologically detected. Although HP[r]