DEVELOPMENT OF A SCORING SYSTEM TO SCREEN FOR BRCA1 2 MUTATIONS

: Kawasaki disease (KD) causes coronary artery lesions (CAL) and is the leading cause of acquired heart disease in children. The aim of this study is to evaluate the risk factors and set-up a scoring system for predicting CAL of KD.

Several works suggest the importance of autophagy during esophageal carcinoma development. The aim of the study is to construct a scoring system according to the expression profiles of major autophagy-related genes (ARGs) among esophageal carcinoma cases.

The aim of this study was to develop a scoring system for prediction of survival prognosis after surgery in patients with symptomatic metastatic spinal cord compression (MSCC) from non-small cell lung cancer (NSCLC).

tumour. Therefore, in these two cases, despite of a BRCA1 pathogenic germline mutation, the tumour- suppressor protein expression is maintained in GBM, suggesting that the BRCA1 mutation is not instrumental for GBM development. This observation is consiste[r]

early China in some sense. The obstacles and improvements to establish an effective credit scoring system are as follows. Most importantly, the availability to relevant individual credit information is limited. Just like the industrial revolution o[r]

Breast cancer risk for BRCA1 and BRCA2 pathogenic mutation carriers is modified by risk factors that cluster in families, including genetic modifiers of risk. We considered genetic modifiers of risk for carriers of high-risk mutations in other breast cancer susceptibility genes.

Lynch syndrome is an autosomal dominant inherited disease caused by germline mutations in mismatch repair genes. Analysis for microsatellite instability (MSI) and immunohistochemistry (IHC) of protein expressions of disease-associated genes is used to screen for Lynch syndrome in endometrial cancer[r]

The aim of this study was to support for finding novel mechanisms that render bacteria resistant to the ribosome targeting antibiotics, we screen for antibiotic resistant 16S and 23S ribosomal RNAs (rRNAs) in multidrug resistant Salmonella serovars isolated from raw retail meats isolated from Hanoi,[r]

Prostate cancer (PC) is a major health concern for men worldwide, with an estimated lifetime risk of ~14 %. A recent comprehensive analysis of mutational processes revealed ageing and mismatch repair as the only altered processes in PC.

Several susceptibility genes have been established for female breast cancer, of which mutations in BRCA1 and especially in BRCA2 are also known risk factors for male breast cancer (MBC). The role of other breast cancer genes in MBC is less well understood.

Germline mutations in the BRCA1 and BRCA2 genes greatly increase a woman’s risk of developing breast and/or ovarian cancer. The prevalence and distribution of such mutations differ across races/ethnicities. Several studies have investigated Chinese women with high-risk breast cancer, but the full sp[r]

Qua nghiên cứu và tiếp cận thực tiễn, bài viết đề cập đến những điểm mới, sửa đổi bổ sung trong Thông tư số 22/2016/TT-BGDĐT về Quy định đánh giá học sinh tiểu học có liên [r]

The two major mechanisms are the acquisition of multiple unrelated resistance genes and the development of mutations in a single gene or gene complex that mediate resistance to a series [r]

Objectoriented system development uses the requirements that were gathered during analysis to create a blueprint for the future system. A successful objectoriented design builds upon what was learned in earlier phases and leads to a smooth implementation by creating a clear, accurate plan of what ne[r]

The human 57 kDa Ki-1 antigen (Ki-1 ⁄ 57) is a cytoplasmic and nuclear protein, associated with Ser ⁄ Thr protein kinase activity, and phosphorylat- ed at the serine and threonine residues upon cellular activation. We have shown that Ki-1 ⁄ 57 interacts with chromo-helicase DNA-binding domain[r]

5th, 2010 Class: 11Cba, 11Cbo2, 11Cbo3  Objectives: By the end of the lesson, Ss will be able to listen to a monologue about the development of Vietnam’s telephone system for details.. [r]

Large genomic rearrangements (LGRs) in the BRCA1/2 genes are frequently observed in breast cancer patients who are negative for BRCA1/2 small mutations. Here, we examined 221 familial breast cancer patients from 37 hospitals to estimate the contribution of LGRs, in a nationwide context, to the devel[r]

Conclusions: These results suggest that GR may be a potential target for BRCA1 in ovarian cancer progression. Keywords: BRCA1, BRCA2, Glucocorticoid receptor, Ovarian cancer
Background
Ovarian cancer is the most lethal gynecological malig- nancy in women worldwide [1][r]

Approximately 10–15% of ovarian carcinomas (OC) are attributed to inherited susceptibility, the majority of which are due to mutations in BRCA1 or BRCA2 (BRCA1/2). These patients display superior clinical outcome, including enhanced sensitivity to platinum-based chemotherapy.

The incidence of breast cancer among young women (aged ≤40 years) has increased in North America and Europe. Fewer than 10% of cases among young women are attributable to inherited BRCA1 or BRCA2 mutations, suggesting an important role for somatic mutations.