THE PROTECTIVE ROLE OF ZINC IN CANCER A POTENTIAL CHEMOPREVENTIVE AGENT
Tìm thấy 10,000 tài liệu liên quan tới từ khóa "THE PROTECTIVE ROLE OF ZINC IN CANCER A POTENTIAL CHEMOPREVENTIVE AGENT":
A NOVEL NAPROXEN DERIVATIVE CAPABLE OF DISPLAYING ANTI-CANCER AND ANTI-MIGRATORY PROPERTIES AGAINST HUMAN BREAST CANCER CELLS
Increasingly, the role of chronic inflammation and its mediators in tumor generation and progression is gaining importance in the field of cancer research. In this context, candidature of non steroidal anti-inflammatory drugs (NSAIDs) as potential anti-tumor therapeutic agent is being evaluated glob[r]
BÁO CÁO KHOA HỌC: STRUCTURE AND FUNCTION OF N-ACETYLGLUCOSAMINE KINASE IDENTIFICATION OF TWO ACTIVE SITE CYSTEINES PPTX
pathway [7],indicating a spatial separation of the two pathways,presumably with different regulation.
GlcNAc kinase has been cloned from man [8] and mouse [9]. Like N -acetylgalactosamine kinase [10] and N -acetyl- mannosamine kinase,as a part of the bifun[r]
GlcNAc kinase has been cloned from man [8] and mouse [9]. Like N -acetylgalactosamine kinase [10] and N -acetyl- mannosamine kinase,as a part of the bifun[r]
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Microcalcifications in breast cancer: An active phenomenon mediated by epithelial cells with mesenchymal characteristics
All breast samples underwent ultrastructural microanalysis. Six-micrometer-thick paraffin sections were embedded in Epon resin following identification of microcalcifications. Briefly, sections were deparaffinized, hydrated, osmium tetroxide-fixed, dehydrated in ethanol and prop[r]
IDENTIFYING FACTORS ASSOCIATED WITH THE DIRECTION AND SIGNIFICANCE OF MICRORNA TUMOR-NORMAL EXPRESSION DIFFERENCES IN COLORECTAL CANCER
MicroRNAs are small non-protein-coding RNA molecules that regulate gene expression, and have a potential epigenetic role in disease progression and survival of colorectal cancer. In terms of tumor-normal expression differences, many microRNAs exhibit evidence of being up-regulated in some subjects b[r]
TISSUE METABOLIC PROFILING OF HUMAN GASTRIC CANCER ASSESSED BY 1 H NMR
Gastric cancer is the fourth most common cancer and the second most deadly cancer worldwide. Study on molecular mechanisms of carcinogenesis will play a significant role in diagnosing and treating gastric cancer.
Mammogram image quality as a potential contributor to disparities in breast cancer stage at diagnosis: An observational study
In an ongoing study of racial/ethnic disparities in breast cancer stage at diagnosis, we consented patients to allow us to review their mammogram images, in order to examine the potential role of mammogram image quality on this disparity.
Silibinin induces mitochondrial NOX4- mediated endoplasmic reticulum stress response and its subsequent apoptosis
Some studies reported that intracellular Ca 2+ flux also mediates multiple cellular signaling cascades of survival and apoptosis. Release of Ca 2+ from ER and high Ca 2+ concentration in cytosol trigger cell death in human cancer cell lines [44]. Our results indica[r]
DIAGNOSTIC ACCURACY AND PREDICTION INCREMENT OF MARKERS OF EPITHELIALMESENCHYMAL TRANSITION TO ASSESS CANCER CELL DETACHMENT FROM PRIMARY TUMORS
Metastases play a role in about 90% of cancer deaths. Markers of epithelial-mesenchymal transition (EMT) measured in primary tumor cancer cells might provide diagnostic information about the likelihood that cancer cells have detached from the primary tumor.
A NOVEL VARIANT ON CHROMOSOME 6P21.1 IS ASSOCIATED WITH THE RISK OF DEVELOPING COLORECTAL CANCER: A TWO-STAGE CASE-CONTROL STUDY IN HAN CHINESE
Genes in inflammatory pathways play a pivotal role in the development of colorectal cancer. We conducted a two-stage case-control study and aimed at screening the colorectal cancer-associated genetic variations in inflammatory genes.
ROLE OF AUTOPHAGY AND LYSOSOMAL DRUG SEQUESTRATION IN ACQUIRED RESISTANCE TO DOXORUBICIN IN MCF-7 CELLS
The roles and mechanisms involved in starvation-induced autophagy in mammalian cells have been extensively studied. However, less is known about the potential role for autophagy as a survival pathway in acquired drug resistance in cancer cells under nutrient-rich conditions.
Phospho-kinase profile of triple negative breast cancer and androgen receptor signaling
Action of DHT on the expression of the AR
We then evaluated the action of DHT and bicalutamide on the expression of AR and how the inhibition of these ki- nases can modulate its expression. Interestingly administra- tion of
We then evaluated the action of DHT and bicalutamide on the expression of AR and how the inhibition of these ki- nases can modulate its expression. Interestingly administra- tion of
Tumor budding outperforms ypT and ypN classification in predicting outcome of rectal cancer after neoadjuvant chemoradiotherapy
Budding is a complementary prognostic factor for colorectal cancer. In this study, we aimed to clarify the role of tumor budding in rectal cancer patients after preoperative chemoradiotherapy.
DIFFERENTIAL KNOCKDOWN OF TGF-Β LIGANDS IN A THREE-DIMENSIONAL CO-CULTURE TUMOR- STROMAL INTERACTION MODEL OF LUNG CANCER
Transforming growth factor (TGF)-β plays a pivotal role in cancer progression through regulating cancer cell proliferation, invasion, and remodeling of the tumor microenvironment. Cancer-associated fibroblasts (CAFs) are the predominant type of stromal cell, in which TGF-β signaling is activated.
Tiamulin inhibits breast cancer growth and pulmonary metastasis by decreasing the activity of CD73
Furthermore, we explored the mechanisms of THF in tumor inhibition by detecting angiogenesis. The development of tumor requires an abundant supply of blood. In the progression and enlargement of solid neoplasms, an important factor is an[r]
COPPER CHELATION SELECTIVELY KILLS COLON CANCER CELLS THROUGH REDOX CYCLING AND GENERATION OF REACTIVE OXYGEN SPECIES
Metals including iron, copper and zinc are essential for physiological processes yet can be toxic at high concentrations. However the role of these metals in the progression of cancer is not well defined. Here we study the anti-tumor activity of the metal chelator, TPEN, and define its mechanism of[r]
Involvement of adiponectin in early stage of colorectal carcinogenesis
Although altered levels of adiponectin have been reported as a potential risk factor in colorectal cancer (CRC), the importance of the role played by adiponectin in colorectal carcinogenesis has not been established.
Naringenin ameliorates renovascular hypertensive renal damage by normalizing the balance of renin-angiotensin system components in rats
Naringenin, a member of the dihydroflavone family, has been shown to have a protective function in multiple diseases. We previously demonstrated that naringenin played a protective role in hypertensive myocardial hypertrophy by decreasing angiotensin-converting enzyme (ACE) expression.
The milk-derived fusion peptide, ACFP, suppresses the growth of primary human ovarian cancer cells by regulating apoptotic gene expression and signaling pathways
ACFP is an anti-cancer fusion peptide derived from bovine milk protein. This study was to investigate the anti-cancer function and underlying mechanisms of ACFP in ovarian cancer. Our results suggest that ACFP may represent a potential therapeutic agent for ovarian cancer that functions by altering[r]
Clinical and basic evaluation of the prognostic value of uric acid in traumatic brain injury
As a major antioxidant in serum, uric acid (UA) was once considered only as the leading cause of gout; however, recent studies have validated its neuroprotective role in ischemic stroke. Because the potential protective effects of UA in traumatic brain injury (TBI) remain largely unknown, this study[r]
Aluminum concentrations in central and peripheral areas of malignant breast lesions do not differ from those in normal breast tissues
Aluminum is used in a wide range of applications and is a potential environmental hazard. The known genotoxic effects of aluminum might play a role in the development of breast cancer. However, the data currently available on the subject are not sufficient to establish a causal relationship between[r]