PROTEOME WIDE IDENTIFICATION OF STAUROSPORINE BINDING KINASES USING CAPTURE COMPOUND MASS SPECTROMET...

Background: The proteomics approach termed proteome pattern analysis has been shown previously to have potential in the detection and classification of breast cancer. Here we aimed to identify changes in serum proteome patterns related to therapy of breast cancer patients[r]

5. Cohen, P. (2002) Protein kinases – the major drug targets of thetwenty-first century? Nat. Rev. Drug Disc. 1, 309–315.6. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. &Sudarsanan, S. (2002) The protein kinase complement of the hu-man genome. Science 298, 1912–1934[r]

Srilakshmi Vemulapalli - vemulasr@onid.orst.edu; Claudia S Maier - claudia.maier@oregonstate.edu; Dennis E Hruby* - hrubyd@oregonstate.edu* Corresponding author AbstractBackground: Although many vaccinia virus proteins have been identified and studied in detail, onlya few studies have attempted a co[r]

genetic contribution to the pathogenesis of the disease comesfrom strong familial aggregation, the strong predominance inpatients with Mediterranean or Asian ancestry, and the con-firmed association with HLA-B51 in several ethnic groups [2-4].It is estimated that the association with HLA-B51[r]

Srilakshmi Vemulapalli - vemulasr@onid.orst.edu; Claudia S Maier - claudia.maier@oregonstate.edu; Dennis E Hruby* - hrubyd@oregonstate.edu* Corresponding author AbstractBackground: Although many vaccinia virus proteins have been identified and studied in detail, onlya few studies have attempted a co[r]

*Fig. 2. Sequence alignment of plant thioredoxin h sequences (A), modelled structure of barley HvTrxh1 (B), using the structure of C. reinhardtii Trx h(PDB accession 1EP7) as a template, and consensus tree of 46 plant thioredoxin h sequences (C), using the a[r]

operators with respect to the crystallographic symmetryelements.The staurosporine molecule extracted from the com-plex SYK–staurosporine was merged onto the ARMdomain, the torsion angles of the side chains of theamino acid residues surrounding staurosporine wereopt[r]

New York.18. Brzezinski, M.R., Abraham, T.L., Stone, C.L., Dean, R.A. &Bosron, W.F. (1994) Purification and characterization of a humanliver cocaine carboxylesterase that catalyzes the production ofbenzoylecgonine and the formation of cocaethylene from alcoholand cocaine. Bioche[r]

Protein Purification 218 Kweon, H.K. & Hakansson, K. (2006) Selective zirconium dioxide-based enrichment of phosphorylated peptides for mass spectrometric analysis. Analytical Chemistry, Vol.78, No.6 (Mar 2006), pp.1743–1749, ISSN: 0003-2700 Larsen, M.R.; Thingholm, T.E.; Jens[r]

enzymes associated with energy metabolism during the early post mortem period in longissi-mus thoracis bovine muscle analyzed by proteomics. Journal of Proteome Research, 5, 1763–1769.Kandarian, S. C. & Jackman, R. W. (2006). Intracellular signaling during skeletal muscle atrop[r]

[Mechanical Translation, vol.3, no.2, November 1956; pp. 33,41] 33 Machine Translation Development at the University of Washington Erwin Reifler, Far Eastern Department, University of Washington, Seattle MACHINE TRANSLATION development at the University of Washington is a joint[r]

N- or C-terminal modifications constitute post-translationalmodifications that can modulate a peptide activity and/orresistance to degradation, as is the case with acetylation,pyroglutamyl formation or C-terminal amidation. Manyproteins and bioactive peptides exhibit an N-terminalpyroglutamyl, which s[r]

Benefits. good for less-polar compounds. excellent LC/MS interface. compatible with MS/MS methodsLimitations. complementary to ESI.Mass range. Low-moderate Typically less than 2000 Da.Laser DesorptionLaser desorption methods use a pulsed laser to desorb species from a target surface. Therefore[r]

4 References 5 2 LIQUID CHROMATOGRAPHY 7 2.1 Introduction 7 2.2 High Performance Liquid Chromatography 10 2.2.1 Pump 10 2.2.2 Sample Introduction Injector 11 2.2.3 Mobile Phase 12 2.2.4 [r]

296 BromisovalumToxic and fatal concentrationsFatal blood bromisovalum concentrations in poisoning with bromisovalum only were reported to be 44.0–93.8 µg/mL by Hishida [10], 67–134 µg/mL by Maguchi [11] and 114 µg/mL by Kojima et al. [12]. In the fatal cases of multiple drug ingestion, blood[r]

Another small subunit protein Rsm23 is a member of theDAP3 family of mitochondrial apoptosis mediators [13].Two large subunit proteins, MrpL31 and Ygl068w the latterof which is probably related to Escherichia coli L7/L12proteins, might be involved in cell cycle control [14].Furthermore[r]

moniae protein, of which the N-terminus of the matureprotein was experimentally determined. For this pro-tein, the predicted cleavage site [23,24] between aminoacids 27 and 28 disagreed with the experimental data,which showed that the processed P1 protein begins withamino acid 70 of[r]