TGFΒ ON THE GROWTH OF HUMAN MYELOID LEUKEMIA CELLS

Cholangiocarcinoma (CCA), a devastating neoplasm, is highly resistant to current chemotherapies. CCA cells frequently overexpress the antiapoptotic protein myeloid cell leukemia-1(Mcl-1), which is responsible for its extraordinary ability to evade cell death.

Risk stratification and prognosis prediction of acute myeloid leukemia (AML) are largely dependent on pre-treatment information. However, post-treatment data also provides much useful information. In this retrospective study, we explored whether the level of blood count recovery before and after the[r]

Tumor-suppressor genes are inactivated by methylation in several cancers including acute myeloid leukemia (AML). Src homology-2 (SH2)-containing protein-tyrosine phosphatase 1 (SHP-1) is a negative regulator of the JAK/STAT pathway.

Growth inhibition assay The antiproliferative effects of IxoA, IxoB, PhilB, Withpc, and ethyl acetate-soluble extract were evaluated in human colon cancer cells using the 3-4,5-dimethylt[r]

The competing endogenous RNA (ceRNA) networks of long non-coding RNAs (lncRNAs) and microRNAs (miRs) have aroused wide concerns. The study aims to investigate the roles of lncRNA DANCRassociated ceRNA network in the growth and behaviors of colon cancer (CC) cells.

TRANG 6 In principle, hESCs are capable of differentiating into all cell types in the adult human, therefore they have the potential to provide a source of tissues for replacement in dis[r]

Prognostic factors aid in the stratification and treatment of cancer. This study evaluated the prognostic significance of human epidermal growth factor receptor (HER) family members (HER1–4) expression in patients with operable pancreatic cancer.

Little is known about the role of glial host cells in brain tumours. However, supporting stromal cells have been shown to foster tumour growth in other cancers. This cell population was subsequently characterised using gene expression analyses and immunocytochemistry. Furthermore, sphere formation w[r]

Chronic myeloid leukemia can be effectively treated with BCR-ABL1 tyrosine kinase inhibitors. However, BCR-ABL1 mutations can develop and cause secondary resistance to these inhibitors.

Chapter 12 shifts focus to the broader system: the implications of human population growth and of anti-poaching enforcement on the one hand, and on the other, of wildlife management area[r]

Serotonin stimulation of HEK293 cells transiently expressing Gs-coupled 5-HT7 receptors induced protein kinase A-dependent phosphorylation of the endogenous human Ras-GRF1 on Ser927 and [r]

SIGNALING AND MLL-MEDIATED LEUKEMIAS TRANG 6 niche in leukemia patients provides an environment in which leukemic cells receive signals to trigger the sur-vival of cancer stem cells, whe[r]

1992 Fidelity of RNA-dependent DNA synthesis exhibited by the reverse transcriptase of human immunodeficiency viruses types 1 and 2 and of murine leukemia virus: mispair extension freque[r]

Acute myeloid leukemia (AML) is a heterogenous hematological malignancy with poor long-term survival. New drugs which improve the outcome of AML patients are urgently required. In this work, the activity and mechanism of action of the cytotoxic indole alkaloid Jerantinine B (JB), was examined in AML[r]

This paper reports research on the effects of human capital, infrastructure capital, and foreign direct investment (FDI) on regional inequality and economic growth in China.. China's dra[r]

Our results indicate the following: a although Ruta is cytotoxic to human and murine cancer cells, it is more damaging to human glioma brain cancer cells than to HL-60 leukemia cells dat[r]

Acute myeloid leukemia (AML) is an aggressive malignancy only cured by intensive therapy. However, many elderly and unfit patients cannot receive such treatment due to an unacceptable risk of treatment-related morbidity and mortality.

... EFFECTS OF SULFIDE- CONTAINING COMPOUNDS ON DEVELOPMENT OF ATHEROSCLEROSIS IN HUMAN UNDOTHELIAL CELLS AND HYPERLIPIDEMIC RABBITS WEN YA-DAN Master of Medicine, Soochow University... Effects of SPRC on ultrastructure of thoracic aorta of NZW rabbits 143 4.4.5 Effects of SPRC on oxidative stress[r]

Targeted therapy has always been the focus in developing therapeutic approaches in cancer, especially in the treatment of acute myeloid leukemia (AML). A new small molecular inhibitor, JQ1, targeting BRD4, which recognizes the acetylated lysine residues, has been shown to induce cell cycle arrest in[r]

The simultaneous Occurrence of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) has been rarely reported. Most of these cases have been occurring more frequently as a secondary event in patients receiving chemotherapeutic agents for CLL.