EFFECT OF SIRNA-SILENCING OF SALL2 GENE ON GROWTH, MIGRATION AND INVASION OF HUMAN OVARIAN CARCINOMA A2780 CELLS

Division of Gynecologic Oncology, Henry Ford Hospital, Detroit, Michigan, USAEmail: Leigh A Solomon - leighsolomon@mac.com; Shadan Ali - alis@karmanos.org; Sanjeev Banerjee - sbanerjee341@hotmail.com; Adnan R Munkarah - amunkar1@hfhs.org; Robert T Morris - morrisr@karmanos.org; Fazlul H Sarka[r]

2. Kelland L: The resurgence of platinum-based cancer chemotherapy. NatRev Cancer 2007, 7:573-584.3. Han ES, Lin P, Wakabayashi M: Current status on biologic therapies in thetreatment of epithelial ovarian cancer. Curr Treat Options Oncol 2009,10:54-66.4. Tummala M[r]

tumor growth [100]. An antibody fragment against anHIV gp160 has also been used for targeted siRNAdelivery in vivo. siRNA linked to a protamine–anti-body fusion protein, called F105-P, showed inhibitedHIV replication in infected primary T cells [101].Moreover, i.t. or i.v. injec[r]

stronger compared to the control group(Fig. 9, 10). Cellsof exposure to TGF-β1(10 μg/L) + IGF(100 μg/L) showeda maximum changes in morphology(Fig. 11). No big dif-ference was noted in cell morphology between TGF-β1and IGF-1 groups.DiscussionIn the present study, we observed profound changes i[r]

Impairment of homologous recombination (HR) is found in close to 50 % of ovarian and breast cancer. Tumors with BRCA1 mutations show increased expression of the Insulin-like growth factor type 1 receptor (IGF-1R). We previously have shown that inhibition of IGF-1R results in growth inhibition and ap[r]

Since function ultimately relies on the fine structure of the chains, cells exercise accurate control over HSPG compos- ition and sequence, which results in these molecules varying depending on factors like cell type and development stage, as well as due to[r]

TPC-1 and BCPAP cells are highly migratory [41, 42]. In both tumor cell lines, our results showed a similar de- gree of inhibition for migration and invasion, suggesting that the effects of miR-146b-5p are mostly associated with the cytoskeleton, a[r]

The widespread use of phthalates as plasticizers has raised public health concerns regarding their adverse effects, including an association with cancer. Although animal investigations have suggested an association between phthalate exposure and hepatocellular carcinoma, the mechanisms are unknown.

As ovarian cancer stem cells (CSCs) are responsible for tumor initiation, invasion, metastasis, and chemo-resistance, new stratagems that selectively target ovarian CSCs are critically significant. Our previous work have demonstrated that ovarian cancer spheroid cells are tumorigenic and chemo-resis[r]

chondrocyte apoptosis during the development of OA,while it may not have definite effects on NO productionin the joints. These inhibitory effects of HA on cell apop-tosis may play a role in its mechanism of action in chon-droprotection [38].Our findings indicated t[r]

MicroRNA-21 (miR-21) is up-regulated in many cancers, including colorectal cancer (CRC). Nevertheless, the function of miR-21 in CRC and the mechanism underlying that function is still unclear.

This study explored the effect of liver resection on perioperative circulating tumor cells (CTCs) and found that the prognostic significance of surgery was associated with changes in CTC counts in patients with hepatocellular carcinoma (HCC).

2a-deficient mice are resistantto collagen-induced arthritis. J Exp Med 197, 1297–1302.53 Myers LK, Kang AH, Postlethwaite AE, Rosloniec EF,Morham SG, Shlopov BV, Goorha S & Ballou LR(2000) The genetic ablation of cyclooxygenase 2 pre-vents the development of autoi[r]

Hepatocellular carcinoma (HCC) is the most common form of liver cancer and the third most lethal cancer worldwide. The epithelial to mesenchymal transition (EMT) describes the transformation of well-differentiated epithelial cells to a de-differentiated phenotype and plays a central role in the inva[r]

Bicyclol, a novel synthetic antihepatitis drug, is widely known to protect against liver injury. However, few reports have focused on the possible effect of bicyclol on anti-proliferation and autophagy induction in cancer cells, particularly hepatocellular carcinoma cells.

keratinocytes. Biotechnol Lett 2010 in press.35. Gray AJ, Reeves JT, Harrison NK, Winlove P, Laurent GJ: Growth factors for human fibroblasts in the solute remaining after clot formation. J Cell Sci 1990, 96:271-4.36. Gray AJ, Bishop JE, Reeves JT, Laurent GJ: A alpha and B beta[r]

80 Fig. 6. Effect of BEL and pyrrophenone on the U937 cell cycle. The cells were synchronized with nocodazole as described in Experimentalprocedures. After releasing the cells from the nocodazole block, they were untreated (open symbols) or treated with 5 lM[r]

CD73 has both enzymatic and non-enzymatic functions in cells. As a nucleotidase, CD73 plays its enzymatic function by catalyzing the hydrolysis of AMP into adenosine and phosphate. In addition to this, accumulating data have shown that CD73 is a key regulatory molecule involved in cancer growth and[r]

The adhesion molecule, FAT4, has a tumor suppressor function with a critical role in the epithelial-tomesenchymal-transition (EMT) and anti-malignant growth in several cancers. No study has investigated yet its role in epithelial ovarian cancer (EOC) progression.

Acknowledgements
We would like to thank Radhika Srinivasan, PhD, for extensive revision of the manuscript. CPN: Fellowship sponsored by Associazione Italiana per la Ricerca sul Cancro (AIRC) (University of Turin); GC: FPO; MS: Fellowship sponsored by AIRC; LG: FPO. SM: My First AIRC[r]